Disease landscape

Glioblastoma clinical trials

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553 active trials 300 recruiting 30 Phase 3 332 sponsors 76 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 46 of 76 changes on 20 trials

2026-08-25
Trial status changed: Enrolling by Invitation → Terminated
Primary completion moved earlier: 2027-07-31 → 2026-07-01
Completion moved earlier: 2027-12-31 → 2026-07-31
NCT03170141 Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme · Shenzhen Geno-Immune Medical Institute · Phase 1
2026-08-18
Recruitment suspended
Recruitment suspended: On hold per study team
NCT05607407 Methimazole in Patients With Progressive Glioblastoma · Case Comprehensive Cancer Center · Phase 2
2026-08-07
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2026-09-30 → 2027-09-30
NCT03862430 A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly… · NuvOx LLC · Phase 2
2026-08-27
Primary completion pushed: 2026-01-12 → 2029-01-03
Enrollment increased: 60 → 86 participants
Trial arms changed: 4 → 5
NCT05236036 Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of… · Northwestern University · Phase 1
2026-08-14
Primary completion pushed: 2026-06 → 2027-06
Enrollment closed, study ongoing
Completion pushed: 2026-06 → 2027-06
NCT05450744 131I-TLX-101 for Treatment of Newly Diagnosed Glioblastoma (IPAX-2) · Telix Pharmaceuticals (Innovations) Pty Limited · Phase 1
2026-07-30
Primary completion pushed: 2026-09-30 → 2027-09-30
Completion pushed: 2026-10-31 → 2027-10-31
NCT05023551 Study of DSP-0390 in Patients With Recurrent High-Grade Glioma · Sumitomo Pharma America, Inc. · Early Phase 1
2026-08-26
Primary completion pushed: 2026-12-31 → 2028-12-31
Completion pushed: 2026-12-31 → 2031-12-31
NCT07076472 Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused… · Mayo Clinic · Early Phase 1
2026-08-28
Primary completion pushed: 2027-02-28 → 2028-03-17
Completion pushed: 2027-12-01 → 2028-12-01
NCT07409584 Mental Health and Suicidality in Glioblastoma Patients in Germany · University Hospital, Essen
2026-08-25
Primary completion pushed: 2027-05-11 → 2027-08-20
Completion pushed: 2027-05-11 → 2028-07-20
NCT04214392 Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the… · City of Hope Medical Center · Phase 1
2026-08-18
Primary completion pushed: 2026-03-05 → 2027-07-01
Enrollment closed, study ongoing
Completion pushed: 2027-03-05 → 2027-07-01
NCT06632236 5G-EMERALD: Amivantamab in Malignant Brain Tumours · Institute of Cancer Research, United Kingdom · Phase 1
2026-08-26
Primary endpoint(s) modified
NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… · Lumina Pharmaceuticals Inc · Early Phase 1
2026-08-11
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2026-07 → 2027-07
NCT04469075 Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side… · Memorial Sloan Kettering Cancer Center · Phase 2
2026-07-31
Primary completion pushed: 2026-07-02 → 2026-11-30
Completion pushed: 2028-07-02 → 2028-11-30
NCT05781321 Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study · Mayo Clinic · Phase 2
2026-08-08
Primary completion pushed: 2030-12 → 2031-10
Recruitment opened
Completion pushed: 2030-12 → 2031-10
NCT07173829 A Study to Better Understand the Biological and Molecular Mechanisms Involved in… · University Hospital, Bordeaux
2026-08-07
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2026-06-30 → 2027-06-30
NCT05086497 WBSI Guided Personalized Delivery of TTFields · Abramson Cancer Center at Penn Medicine
2026-07-31
Primary completion pushed: 2026-01-01 → 2026-12-31
Completion pushed: 2026-01-01 → 2026-12-31
NCT03297125 Assessment of Optune Therapy for Patients With Newly Diagnosed Glioblastoma Using… · Medical College of Wisconsin
2026-08-25
Primary endpoint(s) modified
Enrollment reduced: 78 → 52 participants
Enrollment closed, study ongoing
Primary completion moved earlier: 2026-08-01 → 2026-05-19
NCT05463848 Surgical Pembro +/- Olaparib w TMZ for rGBM · L. Nicolas Gonzalez Castro, MD, PhD · Phase 2
2026-08-08
Primary endpoint(s) modified
Trial arms changed: 3 → 6
NCT04729959 Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to… · National Cancer Institute (NCI) · Phase 2
2026-08-11
Primary endpoint(s) modified
Enrollment increased: 120 → 202 participants
Trial arms changed: 1 → 3
NCT07074756 A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in… · Mayo Clinic
2026-08-20
Sponsor changed: Patrick Wen, MD → David Reardon, MD
NCT02977780 INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT) · David Reardon, MD · Phase 2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07789379 Adebrelimab Plus Temozolomide ± Hyperbaric Oxygen for Primary Glioblastoma Wei Jiang new Phase 2
2026-08-24 NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… Lumina Pharmaceuticals Inc new Early Phase 1
2026-08-21 NCT07779798 A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and… Crossbow Therapeutics, Inc. new Phase 1
2026-08-18 NCT07769918 Hypoxia-targeted Radiotherapy Boost for GBM NYU Langone Health new
2026-08-13 NCT07762716 Combination Immunotherapy Treatment for Glioblastoma Including BreakVax ImmunoTreatment… BreakBio Corp new Phase 1/2
2026-08-10 NCT07754734 STUPP Regimen With or Without Lenvatinib for Newly Diagnosed Glioblastoma With MGMT… Dongguan People's Hospital new Phase 2
2026-08-07 NCT07751744 Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in… Jubilant Therapeutics Inc. new Phase 1/2
2026-07-30 NCT07735819 Positron Emission Tomography/Computed Tomography (PET/CT) Imaging in Patients Diagnosed… Barbara Ann Karmanos Cancer Institute new Phase 2
2026-07-29 NCT07733674 Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma… Radiomedix, Inc. new Phase 1
2026-07-28 NCT07731555 Characterization of the Blood-Brain Barrier in High-Grade Glioma Through… Patrick Morris new

Active trials by phase

Early Phase 1
39
Phase 1
119
Phase 1/2
78
Phase 2
127
Phase 2/3
8
Phase 3
22
Phase 4
3
Not charted: 157 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 553

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT03975829 Pediatric Long-Term Follow-up and Rollover Study Novartis Pharmaceuticals Active, Not Recruiting 2026-08-27
NCT07546669 Efficacy of Zoster Vaccination in Glioblastoma Patients University Hospital, Essen Not Yet Recruiting 2026-04-23
NCT05342883 GammaTile and Stupp in Newly Diagnosed GBM GT Medical Technologies, Inc. Active, Not Recruiting 2025-09-05
Phase 3
NCT06556563 EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus… NovoCure GmbH Recruiting 2026-08-19
NCT05902169 Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU… CarThera Recruiting 2026-08-18
NCT07100730 Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of… Telix Pharmaceuticals (Innovations) Pty Limited Recruiting 2026-08-11
NCT07195591 Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care GT Medical Technologies, Inc. Recruiting 2026-08-10
NCT05904119 Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a… European Organisation for Research and Treatment of Cancer - EORTC Recruiting 2026-06-08
NCT05271240 Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With… Northwell Health Recruiting 2026-06-01
NCT06419946 Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma Vastra Gotaland Region Recruiting 2026-04-13
NCT06496971 A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab… NaviFUS Corporation Recruiting 2026-04-09
NCT07461948 Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in… Jonsson Comprehensive Cancer Center Recruiting 2026-03-10
NCT07021339 Anterior Temporal Lobectomy in Temporal Glioblastoma University Hospital, Bonn Recruiting 2025-06-13
NCT05439278 Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly… Severance Hospital Recruiting 2025-05-21
NCT05095376 Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual… NRG Oncology Active, Not Recruiting 2026-08-17
NCT06448286 PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve… Jonsson Comprehensive Cancer Center Not Yet Recruiting 2026-07-07
NCT06388733 A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed… Ivy Brain Tumor Center Active, Not Recruiting 2026-07-01
NCT07452458 Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the… NRG Oncology Not Yet Recruiting 2026-05-04
NCT03663725 Treatment Intensification With Temozolomide in Adults With a Glioblastoma Centre Oscar Lambret Active, Not Recruiting 2026-03-30
NCT02685605 Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme Universitätsmedizin Mannheim Active, Not Recruiting 2025-10-14
NCT06749925 Clinical Trial Assessing the Efficacy and Safety of Dendritic Cell-Based Immunotherapy… University of Sao Paulo General Hospital Not Yet Recruiting 2025-04-01
NCT05118776 Study to Evaluate the Safety and Efficacy of ASC40 Tablets in Combination With… Ascletis Pharmaceuticals Co., Ltd. Active, Not Recruiting 2024-10-31
NCT06477939 Study of Adding or Not Liposomal Transcrocetin (L-TC) With Concomitant HypoFractionated… Institut de cancérologie Strasbourg Europe Not Yet Recruiting 2024-06-27
NCT05318612 Effectiveness of MR-guided LITT Therapy in Irresectable Glioblastoma (EMITT) Radboud University Medical Center Active, Not Recruiting 2024-04-10
NCT05100641 AV-GBM-1 vs Control as Adjunctive Therapy Following Surgery and RT/TMZ in Newly Diagnosed… Aivita Biomedical, Inc. Not Yet Recruiting 2023-04-10
See all 553 active Glioblastoma trials with filters →

Top sponsors by active trials in this area

National Cancer Institute (NCI) (17) · Mayo Clinic (16) · M.D. Anderson Cancer Center (12) · City of Hope Medical Center (11) · Erasmus Medical Center (7) · Nader Sanai (7) · Northwell Health (7) · Washington University School of Medicine (7) · Jonsson Comprehensive Cancer Center (6) · Memorial Sloan Kettering Cancer Center (6)

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