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NCT07769918 · ClinicalTrials.gov record · last posted 2026-08-18

Hypoxia-targeted Radiotherapy Boost for GBM

Name: Hypoxia-targeted Radiotherapy Boost for GBM — clinical trial record (NCT07769918)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusNot Yet Recruiting

PhaseNot applicable

SponsorNYU Langone Health

Started2026-09-01

View on ClinicalTrials.gov ↗

from the ClinicalTrials.gov record

The purpose of this study is to evaluate the use of dynamic contrast-enhanced MRI (DSC-MRI) to identify and target hypoxic tumor regions in glioblastoma (GBM). The study is divided into two phases: Phase 1 will focus on biologic validation in newly diagnosed GBM patients, while Phase 2 will assess the clinical implementation of DSC-MRI-guided radiotherapy in recurrent or postoperative GBM patients. The primary endpoints are the validation of DSC-MRI in identifying hypoxic regions and assessing the safety and efficacy of radiation therapy based on these findings.

Trial Details

NCT Number	NCT07769918
Lead Sponsor	NYU Langone Health
Conditions	Glioblastoma (GBM)
Enrollment	25 participants
Start Date	2026-09-01
Primary Completion	2028-09-01 (estimated)
Study Completion	2029-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-18