Disease landscape

NASH / MASH clinical trials

Get alerts when NASH / MASH trials change

246 active trials 129 recruiting 13 Phase 3 186 sponsors 33 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-08-11
Primary completion pushed: 2026-08-31 → 2027-09-03
Completion pushed: 2026-10-02 → 2027-12-31
NCT03884075 Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect… · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Phase 2
2026-08-13
Primary completion pushed: 2026-03-31 → 2026-07-01
Enrollment increased: 120 → 141 participants
NCT07007741 Digital Therapy for Fatty Liver Disease · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
2026-08-01
Primary completion pushed: 2026-04-01 → 2027-04-01
Completion pushed: 2026-04-01 → 2027-04-01
NCT07013916 Fructose is a Metabolic and Inflammatory Pathogenic Factor in Metabolic… · Queen Mary University of London
2026-07-31
Primary completion pushed: 2026-01-30 → 2027-01-30
Completion pushed: 2026-01-30 → 2027-01-30
NCT04634643 Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) · Yale University
2026-08-05
Primary endpoint(s) modified
Enrollment reduced: 60 → 50 participants
Enrollment closed, study ongoing
Primary completion pushed: 2027-05-31 → 2027-07-09
Completion pushed: 2027-05-31 → 2027-07-09
NCT04833140 Estrogen Administration for the Treatment of NASH in Postmenopausal Women · Massachusetts General Hospital · Phase 3
2026-08-18
Enrollment reduced: 4000 → 3000 participants
Trial sites expanded: 1 → 4 locations
Trial arms changed: 1 → 2
NCT07070362 Digital Early Warning System for Acute Lung Injury in Liver Surgery · Beijing Tsinghua Chang Gung Hospital
2026-08-13
Enrollment reduced: 45 → 20 participants
Trial completed
Primary completion moved earlier: 2026-05-31 → 2026-02-10
Completion moved earlier: 2026-07-15 → 2026-02-10
NCT04987879 NASH AMPK Exercise Dosing (AMPED) Trial · Milton S. Hershey Medical Center
2026-08-27
Recruitment opened
NCT07660848 A Study of HRS-4729 Injection and HRS9531 Injection in Participants With Metabolic… · Fujian Shengdi Pharmaceutical Co., Ltd. · Phase 2
2026-08-20
Trial completed
NCT04505436 Study to Evaluate Efficacy, Safety and Tolerability of HM15211(Efocipegtrutide) in… · Hanmi Pharmaceutical Company Limited · Phase 2
2026-08-01
Recruitment opened
NCT07512427 Phase 1/2 Study of OPK-88006 in Healthy and Presumed MASH Participants · OPKO Health, Inc. · Phase 1/2
2026-08-01
Sponsor changed: Ali Aminian → The Cleveland Clinic
NCT06374875 Fibrosis Lessens After Metabolic Surgery · The Cleveland Clinic · Phase 4
2026-07-31
Enrollment closed, study ongoing
Primary completion pushed: 2026-05 → 2026-08
Enrollment increased: 8 → 9 participants
Completion pushed: 2026-05 → 2026-09
NCT06947304 Evaluation of Miricorilant on Liver Fat in Patients With MASLD · Corcept Therapeutics · Phase 1
2026-08-11
Enrollment closed, study ongoing
NCT07466017 A Study of CS060380 Tablets in Patients With MASH and Obesity · Cascade Pharmaceuticals, Inc · Phase 2
2026-08-20
Trial sites expanded: 323 → 329 locations
NCT06528314 A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH · Akero Therapeutics, Inc · Phase 3
2026-08-06
Trial sites expanded: 317 → 321 locations
NCT06419374 A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With… · 89bio, Inc. · Phase 3
2026-08-06
Trial sites expanded: 361 → 365 locations
NCT06318169 A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and… · 89bio, Inc. · Phase 3
2026-08-02
Trial status changed: Recruiting → Unknown
NCT04697810 Namodenoson in the Treatment of Non-Alcoholic Steatohepatitis (NASH) · Can-Fite BioPharma · Phase 2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-20 NCT07775638 Detecting Liver Fibrosis in Patients At-risk Helse Stavanger HF new
2026-07-31 NCT07740109 The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic… Tabriz University of Medical Sciences new
2026-07-30 NCT07737340 Metabolic Liver Disease in Newly Diagnosed People Living With HIV (MASHIV-TR) Yaşar Bayındır, MD new
2026-07-28 NCT07730853 Isocaloric Navy-Bean Substitution in Adults With MASLD Icahn School of Medicine at Mount Sinai new
2026-07-28 NCT07732400 A Study of VV-14303 for the Treatment of Metabolic Dysfunction-associated Steatohepatitis… Kriya Therapeutics, Inc. new Phase 1/2
2026-07-24 NCT07726368 Study of ECC4703 With Sulfasalazine and Pitavastatin Eccogene new Phase 1
2026-07-21 NCT07716384 Wearable Patch Ultrasound Probe for Diagnosis of Liver Stiffness Second Affiliated Hospital of Xi'an Jiaotong University new
2026-07-20 NCT07713992 Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate… Tianjin Medical University new
2026-07-09 NCT07692438 Taiwan Green Propolis for Blood Lipids and Body Fat in Patients With MASLD Taipei Medical University new
2026-07-02 NCT07680478 Nutrition Intervention Combined With Resmetirom for MASH City University of New York new Phase 4

Active trials by phase

Early Phase 1
2
Phase 1
11
Phase 1/2
4
Phase 2
38
Phase 3
13
Phase 4
10
Not charted: 168 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 246

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06374875 Fibrosis Lessens After Metabolic Surgery The Cleveland Clinic Recruiting 2026-07-31
NCT07249788 Resmiterom Efficacy & Safety in Patients With MASH Nabiqasim Industries (Pvt) Ltd Recruiting 2025-12-03
NCT06449833 Effect of Henagliflozein on Hepatic Fat Content in Patients With T2DM and NAFLD Zhujiang Hospital Recruiting 2024-06-10
NCT06368882 Efficacy and Safety of Antiviral Therapy With Peg-interferon for Chronic Hepatitis B… First Affiliated Hospital of Wenzhou Medical University Recruiting 2024-04-16
NCT06523530 Effect of a GnRH Analog on Hepatic Steatosis Aristotle University Of Thessaloniki Active, Not Recruiting 2026-07-23
NCT07680478 Nutrition Intervention Combined With Resmetirom for MASH City University of New York Not Yet Recruiting 2026-07-06
NCT05195944 Semaglutide vs Sitagliptin University Health Network, Toronto Enrolling by Invitation 2026-04-06
NCT05147090 Effects of Empagliflozin on Fibrosis and Cirrhosis in Chronic Hepatitis B Patients The University of Hong Kong Active, Not Recruiting 2026-01-30
NCT07180745 Empagliflozin Versus Statins in Non-Alcoholic Fatty Liver Disease Badr University Not Yet Recruiting 2025-09-18
NCT06918080 Hepatoprotective Measures for Children at High Risk of NAFLD Ain Shams University Active, Not Recruiting 2025-04-09
Phase 3
NCT06632444 LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called… Boehringer Ingelheim Recruiting 2026-08-21
NCT06528314 A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH Akero Therapeutics, Inc Recruiting 2026-08-19
NCT06215716 A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic… Akero Therapeutics, Inc Recruiting 2026-08-07
NCT06318169 A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and… 89bio, Inc. Recruiting 2026-08-05
NCT06419374 A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With… 89bio, Inc. Recruiting 2026-08-05
NCT05935826 Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study) University of Colorado, Denver Recruiting 2025-08-28
NCT04833140 Estrogen Administration for the Treatment of NASH in Postmenopausal Women Massachusetts General Hospital Active, Not Recruiting 2026-08-07
NCT04822181 Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis… Novo Nordisk A/S Active, Not Recruiting 2026-08-04
NCT05500222 A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients… Madrigal Pharmaceuticals, Inc. Active, Not Recruiting 2026-07-08
NCT04849728 A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active… Inventiva Pharma Active, Not Recruiting 2026-07-02
NCT07581951 A Phase 3 Study Evaluating the Safety and Efficacy of HSK31679 in Patients With MASH Haisco Pharmaceutical Group Co., Ltd. Not Yet Recruiting 2026-06-17
NCT03900429 A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients… Madrigal Pharmaceuticals, Inc. Active, Not Recruiting 2026-06-01
NCT06161571 A Study Evaluating Efruxifermin in Subjects With Non-invasively Diagnosed Nonalcoholic… Akero Therapeutics, Inc Active, Not Recruiting 2026-04-30
Phase 2
NCT07335601 Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH Madrigal Pharmaceuticals, Inc. Recruiting 2026-08-26
NCT07660848 A Study of HRS-4729 Injection and HRS9531 Injection in Participants With Metabolic… Fujian Shengdi Pharmaceutical Co., Ltd. Recruiting 2026-08-26
See all 246 active NASH / MASH trials with filters →

Top sponsors by active trials in this area

Assiut University (6) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (6) · Madrigal Pharmaceuticals, Inc. (5) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (4) · Ain Shams University (3) · Akero Therapeutics, Inc (3) · Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis (3) · Beijing Friendship Hospital (3) · Cascade Pharmaceuticals, Inc (3) · Corcept Therapeutics (3)

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