The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

To determine the effect of MTHF supplementation on serum folate and homocysteine level, metabolic, nutritional status, liver function, and PPARα and TNFα gene expression in patients with MASLD

NCT Number	NCT07740109
Lead Sponsor	Tabriz University of Medical Sciences
Conditions	Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD), MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD, NAFLD, Metabolic Dysfunction-Associated Steatotic Liver Disease, NAFLD (Nonalcoholic Fatty Liver Disease), NAFLD (Non-alcoholic Fatty Liver Disease) +2 more
Enrollment	44 participants
Start Date	2026-09-30
Primary Completion	2027-08-30 (estimated)
Study Completion	2027-08-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-31