Drug Pipeline

Leucovorin Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
118
Active Studies
64
Recruiting
34
Phase 3
10
Top Sponsors
37
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-12 NCT05647122
First in Human Study of AZD9592 in Solid Tumors
overall status: "Recruiting" → "Active Not Recruiting"
2026-06-12 NCT05647122
First in Human Study of AZD9592 in Solid Tumors
Enrollment reduced: 403 -> 167 participants
2026-06-12 NCT05647122
First in Human Study of AZD9592 in Solid Tumors
Trial sites reduced: 51 -> 46 locations
2026-06-11 NCT05083481
A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together With Either Pembrolizumab…
Trial terminated
2026-06-11 NCT05083481
A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together With Either Pembrolizumab…
date change Primary completion moved earlier: 2026-06-30 -> 2026-05-11
2026-06-11 NCT05083481
A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together With Either Pembrolizumab…
date change Completion moved earlier: 2026-06-30 -> 2026-05-11
2026-06-06 NCT06901531
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With…
Trial sites expanded: 238 -> 246 locations
2026-06-06 NCT05891171
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
date change Primary completion pushed: 2026-03 -> 2027-09
2026-06-06 NCT05891171
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
date change Completion pushed: 2026-03 -> 2027-09
2026-06-06 NCT05355701
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced…
date change Primary completion moved earlier: 2029-02-02 -> 2028-04-23
2026-06-06 NCT05355701
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced…
date change Completion moved earlier: 2030-08-06 -> 2029-10-25
2026-06-05 NCT05253651
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in…
date change Primary completion pushed: 2026-04-03 -> 2027-12-31
2026-06-05 NCT05253651
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in…
date change Completion pushed: 2029-07-27 -> 2030-07-03
2026-06-03 NCT05146739
Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients…
date change Completion pushed: 2026-05-09 -> 2027-05-09
2026-05-30 NCT07043400
A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus…
Trial sites expanded: 86 -> 93 locations
2026-05-30 NCT06820463
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab…
Trial sites reduced: 50 -> 47 locations
2026-05-29 NCT02883049
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B…
Trial completed
2026-05-29 NCT02883049
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B…
date change Completion moved earlier: 2026-10-03 -> 2026-03-31
2026-05-29 NCT06901531
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With…
Trial sites expanded: 224 -> 238 locations
2026-05-28 NCT07431281
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in…
Trial sites expanded: 258 -> 269 locations
Showing 20 of 37 changes detected in the last 30 days.
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-11 NCT07642661 A Placebo-controlled Trial of Folinic Acid in Children With ASD Phase 2 Not Yet Recruiting
2026-06-09 NCT07636564 Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute… Phase 2 Not Yet Recruiting
2026-06-05 NCT07630506 Folinic Acid as a Treatment for Autism Spectrum Disorder in Children Phase 2 Recruiting
2026-06-02 NCT07619313 AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients… Phase 1 Not Yet Recruiting
2026-06-02 NCT07621718 Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of… Phase 3 Recruiting
2026-05-26 NCT07606599 A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With… Phase 3 Not Yet Recruiting
Active Studies by Phase
Phase 3
34
Phase 2
46
Phase 1/2
9
Phase 1
26
Early Phase 1
2
Not specified
1
Active Trials — top 25 of 118
NCT IDTitleConditionStatus
Phase 3
NCT06958328 Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma Recruiting
NCT03959085 Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk… B Acute Lymphoblastic Leukemia Recruiting
NCT03801876 Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer Clinical Stage I Esophageal Adenocarcinoma AJCC v8 Recruiting
NCT05677490 mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced… Advanced Esophageal Adenocarcinoma Recruiting
NCT06998940 Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or… Locally Advanced Pancreatic Adenocarcinoma Recruiting
NCT07431281 Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in… Gastric Cancer Recruiting
NCT07043400 A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus… Metastatic Gastric Adenocarcinoma Recruiting
NCT05863195 Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of… Metastatic Colorectal Carcinoma Recruiting
NCT07409272 A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either… Pancreatic Cancer Recruiting
NCT07621718 Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of… Pancreatic Cancer Recruiting
NCT05253651 A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in… Colorectal Neoplasms Recruiting
NCT06901531 A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With… Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer Recruiting
NCT06205485 Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer Rectal Cancer Recruiting
NCT03020030 Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Acute Lymphoblastic Leukemia, Pediatric Active, Not Recruiting
NCT04340141 Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable… Pancreatic Adenosquamous Carcinoma Active, Not Recruiting
NCT04094688 Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or… Colorectal Adenocarcinoma Active, Not Recruiting
NCT03007147 Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed… Acute Lymphoblastic Leukemia Active, Not Recruiting
NCT03504397 A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy… Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer Active, Not Recruiting
NCT04248452 Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients… Clinical Stage IV Esophageal Adenocarcinoma AJCC v8 Active, Not Recruiting
NCT04210115 Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma… Esophageal Squamous Cell Carcinoma (ESCC) Active, Not Recruiting
NCT04927780 Perioperative or Adjuvant mFOLFIRINOX for Resectable Pancreatic Cancer Pancreatic Cancer Active, Not Recruiting
NCT05239741 Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage… Colorectal Neoplasms Active, Not Recruiting
NCT07582315 A Study Comparing BL-B01D1 With Treatment of Physician's Choice in Patients With Locally… Biliary Tract Cancer Not Yet Recruiting
NCT07606599 A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With… Biliary Tract Cancer Not Yet Recruiting
NCT03914625 A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With… B Acute Lymphoblastic Leukemia Active, Not Recruiting
Sponsors Running Leucovorin Trials
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