Clinical Trial

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Study acronym: NEO-RT
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
This study is being done to answer the following questions: Is the chance of rectal cancer responding the same if chemotherapy alone is given before limited surgery compared to chemotherapy and radiation therapy given together before limited surgery? If radiation therapy is not given, is quality of life better?
Protocol Amendment History 2 changes
notable Trial sites expanded: 109 -> 113 locations 2026-07-15
notable Trial sites expanded: 100 -> 105 locations 2026-04-15
Trial Details
NCT Number NCT06205485
Lead Sponsor Canadian Cancer Trials Group
Collaborators: Alliance for Clinical Trials in Oncology, ECOG-ACRIN Cancer Research Group, NRG Oncology, SWOG Cancer Research Network
Conditions Rectal Cancer
Enrollment 250 participants
Start Date 2024-06-26
Primary Completion 2030-01-30 (estimated)
Study Completion 2030-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-14