Disease landscape

Acute Lymphoblastic Leukemia (ALL) clinical trials

Get alerts when Acute Lymphoblastic Leukemia (ALL) trials change

688 active trials 405 recruiting 50 Phase 3 310 sponsors 94 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 51 of 94 changes on 20 trials

2026-08-20
Trial terminated
Trial terminated: Study was terminated prematurely by the Sponsor for reasons not related to the safety of study drug
Enrollment reduced: 10 → 4 participants
Primary completion moved earlier: 2028-12 → 2026-07-01
Completion moved earlier: 2028-12 → 2026-07-01
NCT07556757 A Safety and Efficacy Study of CD-19 t-haNK in Patients With B-cell Acute Lymphoblastic… · ImmunityBio, Inc. · Phase 1
2026-08-25
Trial terminated
Primary completion moved earlier: 2029-12-31 → 2026-07-01
Completion moved earlier: 2030-12-31 → 2026-07-31
NCT05277753 NGS-MRD Assessment of Combination Immunotherapies Targeting T-ALL · Shenzhen Geno-Immune Medical Institute · Phase 1
2026-08-25
Trial terminated
Primary completion moved earlier: 2029-12-31 → 2026-07-01
Completion moved earlier: 2030-12-31 → 2026-07-31
NCT05262673 NGS-MRD Assessment of Combination Immunotherapies Targeting B-ALL · Shenzhen Geno-Immune Medical Institute · Phase 1
2026-08-21
Trial terminated
Trial terminated: \<75% participants
Primary completion moved earlier: 2026-11-30 → 2026-08-14
Completion moved earlier: 2026-11-30 → 2026-08-14
NCT02392572 ONC201 in Treating Patients With Relapsed or Refractory Acute Leukemia or High-Risk… · M.D. Anderson Cancer Center · Phase 1/2
2026-08-14
Withdrawn before enrolling
Trial withdrawn: The trial has been stopped pending FDA approval of modifications to the trial protocol.
Enrollment reduced: 24 → 0 participants
NCT06703216 Pre-emptive Anakinra for Cytokine Event Reduction · Kevin McNerney · Phase 1/2
2026-08-21
Primary completion pushed: 2028-06-30 → 2028-12-31
Completion pushed: 2028-06-30 → 2028-12-31
NCT05579132 A Clinical Study of MK-1045 (CN201) in People With Precursor B-cell Acute Lymphoblastic… · MSD R&D (China) Co., Ltd. · Phase 1/2
2026-08-20
Primary completion pushed: 2026-11-13 → 2028-02-11
Primary endpoint(s) modified
Completion pushed: 2027-06-29 → 2028-09-15
Trial arms changed: 3 → 4
NCT06137118 AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia · AstraZeneca · Phase 1/2
2026-08-28
Primary completion pushed: 2029-08-31 → 2030-08-31
Completion pushed: 2031-08-31 → 2032-08-31
NCT07691645 Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome · Xiang-Qian · Phase 2
2026-08-18
Primary completion pushed: 2026-01-31 → 2026-12-31
NCT06927466 A Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of B019… · Shanghai Pharmaceutical Group Biological Therapy Technology Co., Ltd. · Phase 1
2026-08-27
Primary completion pushed: 2026-08-06 → 2027-07-14
Completion pushed: 2026-08-06 → 2027-07-14
NCT02159495 Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory… · City of Hope Medical Center · Phase 1
2026-08-27
Primary completion pushed: 2026-09-30 → 2028-07-31
Trial status changed: Recruiting → Not Yet Recruiting
Completion pushed: 2026-12-31 → 2028-12-31
NCT05995028 Universal 4SCAR7U Targeting CD7-positive Malignancies · Shenzhen Geno-Immune Medical Institute · Phase 1
2026-08-01
Primary completion pushed: 2026-06-14 → 2026-09-29
Completion pushed: 2026-07-13 → 2026-09-29
NCT07295951 A Study of 14C-Bleximenib (Radiolabeled) in Participants With Acute Leukemia · Janssen Research & Development, LLC · Phase 1
2026-08-18
Primary completion pushed: 2026-02-01 → 2026-12-24
Completion pushed: 2026-06-30 → 2026-12-30
NCT06001385 HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced… · Center for International Blood and Marrow Transplant Research · Phase 2
2026-08-15
Primary completion pushed: 2026-03-01 → 2028-04-01
Completion pushed: 2027-03-01 → 2028-04-01
NCT06274788 Safety Study to Evaluate the Occurrence of EFAD in Pediatric Patients With PNAC Who… · Fresenius Kabi
2026-08-22
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2027-05 → 2028-05
NCT06227026 Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the… · University of Utah · Phase 1
2026-08-20
Primary completion pushed: 2026-10-15 → 2027-08-15
Trial sites reduced: 20 → 16 locations
Completion pushed: 2031-10-15 → 2032-08-15
NCT05082519 Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL · Etan Orgel · Phase 2
2026-08-20
Primary completion pushed: 2026-08-06 → 2026-12-01
Completion pushed: 2026-08-06 → 2026-12-01
NCT07224659 Exercise and Mortality in Middle-Aged and Older Adults · City of Hope Medical Center
2026-08-07
Primary completion pushed: 2026-08-31 → 2028-08-31
Completion pushed: 2026-08-31 → 2028-08-31
NCT02861417 Busulfan, Fludarabine Phosphate, and Post-Transplant Cyclophosphamide in Treating… · M.D. Anderson Cancer Center · Phase 2
2026-08-06
Primary completion pushed: 2026-07-15 → 2027-06-17
Completion pushed: 2026-07-15 → 2027-06-17
NCT02146924 Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia · City of Hope Medical Center · Phase 1
2026-08-15
Primary completion pushed: 2026-06-30 → 2027-05-25
Completion pushed: 2026-06-30 → 2027-05-25
NCT04537871 Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study · City of Hope Medical Center

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-21 NCT07780123 Nurture by Nature Feasibility Study Ina Olmer Specht new
2026-08-20 NCT07776301 Application of CT-Linac-Based "All-in-One" One-Stop Radiotherapy in Breast Cancer Fudan University new
2026-08-18 NCT07770698 A Study of Sonrotoclax (BGB-11417) in Children With Relapsed or Refractory Acute Myeloid… BeOne Medicines new Phase 1/2
2026-08-13 NCT07763054 Low-dose Liposomal Amphotericin B for Antifungal Prophylaxis in Prolonged Neutropenia… Haikou Affiliated Hospital of Central South University Xiangya School of Medicine new
2026-08-04 NCT07745101 Research On Advanced Diagnostics and Management of All Pregnancies to Prevent Stillbirth… RTI International new
2026-07-30 NCT07736261 Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian… Ahmed Saad new Phase 1/2
2026-07-29 NCT07733219 Multicentre Phase II Trial Evaluating Stereotactic Body Radiotherapy on Ultra-central… Centre Oscar Lambret new
2026-07-14 NCT07701200 OT-Bridge System Versus Multiunit Abutment for Mandibular All On-4 Screw Retained… Mansoura University new
2026-07-10 NCT07696481 Clinical Study on the Safety and Efficacy of PID23 Injection in Patients With… Zhujiang Hospital new Early Phase 1
2026-07-10 NCT07695012 CAR-T Cell Therapy for ALL Dr. Zaineb Akram new Early Phase 1

Active trials by phase

Early Phase 1
33
Phase 1
132
Phase 1/2
87
Phase 2
153
Phase 2/3
16
Phase 3
34
Phase 4
8
Not charted: 225 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 688

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06289673 Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute… St. Jude Children's Research Hospital Recruiting 2026-07-14
NCT07016165 Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in… Gadjah Mada University Recruiting 2025-08-22
NCT06918054 Hepatoprotective for Children and Adolescent With Acute Lymphoblastic Leukemia Ain Shams University Recruiting 2025-04-09
NCT06410833 Belimumab After Rituximab in Resistant Primary Juvenile SS Peking Union Medical College Hospital Recruiting 2024-05-16
NCT05682131 South China Children Cancer Group - Relapsed-Acute Lymphoblastic Leukemia 2022 Protocol Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Recruiting 2023-01-12
NCT07320534 Levofloxacin Prophylaxis to Prevent First Febrile Neutropenia in Pediatric ALL During… Gadjah Mada University Not Yet Recruiting 2026-01-08
NCT06918080 Hepatoprotective Measures for Children at High Risk of NAFLD Ain Shams University Active, Not Recruiting 2025-04-09
NCT06711679 Exploring the Minimum Effective Concentration and Volume of Ropivacaine for Sacral Plexus… Yilin Zhao Enrolling by Invitation 2024-12-02
Phase 3
NCT03959085 Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk… Children's Oncology Group Recruiting 2026-08-25
NCT07223021 A Study of Fludarabine Dosing in Children and Young Adults With B-cell Acute… Memorial Sloan Kettering Cancer Center Recruiting 2026-08-17
NCT03150693 Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly… Alliance for Clinical Trials in Oncology Recruiting 2026-08-05
NCT05327894 Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or… Princess Maxima Center for Pediatric Oncology Recruiting 2026-07-10
NCT04094311 Study of Out of Specification for Tisagenlecleucel Novartis Pharmaceuticals Recruiting 2026-06-25
NCT06051409 A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ ALL (POLARIS-1) Ascentage Pharma Group Inc. Recruiting 2026-04-30
NCT07441291 CD19 CAR-T vs DLI for Post-HSCT MRD in Ph- ALL: A RCT Peking University People's Hospital Recruiting 2026-02-27
NCT06819592 PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury The George Institute Recruiting 2026-02-19
NCT07203352 Efficacy of Targeted Drugs Combined With Chemotherapy in the Treatment of T-ALL Nanfang Hospital, Southern Medical University Recruiting 2025-10-02
NCT07152041 Newly-diagnosed Pediatric Ph-positive B-ALL Protocol Institute of Hematology & Blood Diseases Hospital, China Recruiting 2025-09-03
NCT03643276 Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia… Martin Schrappe Recruiting 2025-04-06
NCT04314219 Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for… King Faisal Specialist Hospital & Research Center Recruiting 2025-03-13
NCT06361329 Comparing the Efficacy of VHAG and Traditional Chemotherapy Regimens in Newly Diagnosed… First Affiliated Hospital of Zhejiang University Recruiting 2025-02-17
NCT05029531 Combined Immuno-chemotherapy for Patients With B-linear Acute Lymphoblastic Leukemia… Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting 2024-06-28
NCT05602194 Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for… Children's Oncology Group Active, Not Recruiting 2026-08-21
NCT04530565 Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or… National Cancer Institute (NCI) Active, Not Recruiting 2026-08-20
NCT03007147 Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed… Children's Oncology Group Active, Not Recruiting 2026-08-19
See all 688 active Acute Lymphoblastic Leukemia (ALL) trials with filters →

Top sponsors by active trials in this area

City of Hope Medical Center (31) · Institute of Hematology & Blood Diseases Hospital, China (27) · St. Jude Children's Research Hospital (26) · M.D. Anderson Cancer Center (21) · National Cancer Institute (NCI) (19) · Memorial Sloan Kettering Cancer Center (18) · The First Affiliated Hospital of Soochow University (16) · Zhejiang University (12) · Baylor College of Medicine (11) · Children's Oncology Group (10)

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