Clinical Trial

Exercise and Mortality in Middle-Aged and Older Adults

Not Yet Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated February 4, 2026 (before its estimated August 6, 2026 completion). Its status may not reflect the trial's current state.
Summary
This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-11-02.
Trial Details
NCT Number NCT07224659
Lead Sponsor City of Hope Medical Center
Conditions Overall Survival (All-cause Mortality)
Enrollment 19,000 participants
Start Date 2026-04-01
Primary Completion 2026-08-06 (estimated)
Study Completion 2026-08-06 (estimated)
Updated on ClinicalTrials.gov 2026-02-04