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NCT05995028 · ClinicalTrials.gov record · last posted 2026-08-26

Universal 4SCAR7U Targeting CD7-positive Malignancies

StatusNot Yet Recruiting
PhasePhase 1
Started2027-06-30
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from the ClinicalTrials.gov record
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of universal CAR T cells based on 4SCAR7U design against CD7-positive hematological malignancies using CD7 specific universal CAR T cells. The study also aims to learn more about the function of CD7 targeting CAR T cells and their persistence in patients of hematological malignancies.

Protocol amendment history 3 changes detected by DataLookout

2026-08-27
Trial status changed: Recruiting → Not Yet Recruiting
2026-08-27
Primary completion pushed: 2026-09-30 → 2028-07-31
2026-08-27
Completion pushed: 2026-12-31 → 2028-12-31
Trial Details
NCT Number NCT05995028
Lead Sponsor Shenzhen Geno-Immune Medical Institute
Conditions T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma, Acute Myeloid Leukemia, NK Cell Lymphoma
Enrollment 30 participants
Start Date 2027-06-30
Primary Completion 2028-07-31 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-26