Disease landscape

Esophageal Cancer clinical trials

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440 active trials 260 recruiting 34 Phase 3 257 sponsors 48 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 41 of 48 changes on 20 trials

2026-08-14
Trial terminated
Trial terminated: Following completion of Phase 1b, the Sponsor decided not to initiate Part 2 of the trial.
Primary endpoint(s) modified
Primary completion moved earlier: 2025-07 → 2025-04-30
Completion moved earlier: 2025-11 → 2025-04-30
NCT05572684 A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants… · NextCure, Inc. · Phase 1/2
2026-08-14
Trial terminated
Trial terminated: \<75% participation
Primary completion moved earlier: 2027-12-31 → 2026-08-06
Completion moved earlier: 2027-12-31 → 2026-08-06
NCT06549413 18F-FSPG PET/CT as a Non-Invasive Imaging Biomarker for Treatment Response to… · M.D. Anderson Cancer Center
2026-08-06
Trial terminated
Trial terminated: local ethics review
NCT07629921 Multimodal Al for Precision Diagnosis of Esophageal Cancer · Shanghai Zhongshan Hospital
2026-07-30
Primary completion pushed: 2025-11 → 2028-05
Primary endpoint(s) modified
Trial sites expanded: 45 → 54 locations
Completion pushed: 2027-11 → 2028-11
NCT03526835 A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors · Merus B.V. · Phase 1/2
2026-08-06
Primary completion pushed: 2026-05 → 2027-06
Primary endpoint(s) modified
Completion pushed: 2026-05 → 2027-06
Trial arms changed: 17 → 18
NCT04999761 AB122 Platform Study · Taiho Pharmaceutical Co., Ltd. · Phase 1
2026-08-22
Primary completion pushed: 2026-05-31 → 2028-05-31
Completion pushed: 2026-05-31 → 2028-05-31
NCT05205343 Trans-Pacific Multicenter Collaborative Study of Minimally Invasive Proximal Versus Total… · M.D. Anderson Cancer Center
2026-08-26
Primary endpoint(s) modified
NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… · Lumina Pharmaceuticals Inc · Early Phase 1
2026-08-15
Primary completion pushed: 2026-06-30 → 2027-04-30
NCT04221893 Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers · University of California, San Francisco
2026-08-12
Primary completion pushed: 2026-11-11 → 2027-11-11
Completion pushed: 2027-11-11 → 2028-11-11
NCT06687291 Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer · Karolinska Institutet
2026-08-07
Primary completion pushed: 2026-06-30 → 2026-09-30
Completion pushed: 2026-07-31 → 2026-12-31
NCT07596654 The Impact of Surgical Treatment on Survival in Localized Small Cell Esophageal Cancer · yi shen
2026-08-28
Primary endpoint(s) modified
Interventions modified
NCT06414733 HER-2 B Cell Peptide Vaccine · Pravin T.P Kaumaya · Phase 1
2026-08-01
Primary endpoint(s) modified
NCT00242723 Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung… · National Cancer Institute (NCI)
2026-08-07
Enrollment reduced: 450 → 165 participants
Enrollment closed, study ongoing
Trial sites reduced: 41 → 36 locations
NCT05581004 A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single… · Genentech, Inc. · Phase 1
2026-08-25
Enrollment reduced: 400 → 200 participants
NCT05517811 Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing… · University of Colorado, Denver
2026-08-26
Recruitment opened
NCT07594626 BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors… · Northwestern University · Phase 1/2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT05307835 Neoantigen Vaccine in Esophagus Cancer Patients Following Neoadjuvant Therapy and… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 1
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06822413 Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-07-31
Trial completed
Completion moved earlier: 2026-06 → 2025-06-12
NCT05438940 Support Through Remote Observation and Nutrition Guidance (STRONG) Program for… · H. Lee Moffitt Cancer Center and Research Institute
2026-08-18
Trial sites expanded: 6 → 15 locations
NCT07519655 Phase 1 Study of PF-08046033 in Advanced Solid Tumors · Pfizer · Phase 1
2026-08-07
Trial sites expanded: 6 → 9 locations
NCT07227168 A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer · Sutro Biopharma, Inc. · Phase 1

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-24 NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… Lumina Pharmaceuticals Inc new Early Phase 1
2026-08-21 NCT07780721 Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment… The Affiliated Hospital of Putian University new Phase 2
2026-08-18 NCT07770100 Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy… Mark Bernard new Phase 2
2026-08-18 NCT07770672 An Exploratory Clinical Study of Accurate Efficacy Assessment of Neoadjuvant… Tan Lijie new Phase 2
2026-08-07 NCT07752875 A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53… LG Chem new Phase 1/2
2026-07-24 NCT07726212 A First-in-human (FIH), Open-Label, Dose Escalation and Expansion Cohorts Study of MC002 Hangzhou MacroLink Biopharmaceutical LLC new Phase 1
2026-07-23 NCT07722819 ESCC Molecular Subtypes Based on Multidimensional Features of p53 and Their Clinical… Ling Zhiqiang new
2026-07-14 NCT07700420 Perioperative FLOT(D) With Personalized Ultrafractionated Stereotactic Adaptive… University of Texas Southwestern Medical Center new Phase 1
2026-07-09 NCT07692204 A Dose Optimization/Expansion Study of SAR445877 in Adult Chinese Participants With… Sanofi new Phase 2
2026-07-09 NCT07691944 Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients First Affiliated Hospital of Chongqing Medical University new

Active trials by phase

Early Phase 1
4
Phase 1
64
Phase 1/2
39
Phase 2
91
Phase 2/3
4
Phase 3
30
Phase 4
4
Not charted: 204 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 440

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05183126 Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With… University of Michigan Rogel Cancer Center Recruiting 2026-07-02
NCT07124351 Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™) Cedars-Sinai Medical Center Recruiting 2025-09-15
NCT06437288 Hematoporphyrin Photodynamic Therapy for Esophageal Cancer Sun Yat-sen University Enrolling by Invitation 2026-05-22
NCT06963593 Clinical Study on the Treatment of Anorexia and Cachexia in Advanced Gastric and… Peking University Not Yet Recruiting 2025-05-09
Phase 3
NCT04415853 Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer Sunshine Lake Pharma Co., Ltd. Recruiting 2026-08-24
NCT07431281 Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in… AstraZeneca Recruiting 2026-07-01
NCT07217704 Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or… SOFIE Recruiting 2026-06-30
NCT05357846 PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally… Sun Yat-sen University Recruiting 2026-04-30
NCT07177794 Consolidation of Toripalimab and Capecitabine After Chemoradiotherapy in ESCC Sun Yat-sen University Recruiting 2026-04-21
NCT06964568 CCRT Followed by PD-1 Inhibitor Maintenance Therapy in Locally Advanced ESCC Fudan University Recruiting 2026-04-17
NCT04871412 The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III Ottawa Hospital Research Institute Recruiting 2026-01-30
NCT04821843 Neoadjuvant Treatment Modalities in Esophageal Cancer Cancer Institute and Hospital, Chinese Academy of Medical Sciences Recruiting 2026-01-21
NCT06676449 TDLN-sparing RT Plus Immunotherapy and Chemotherapy in Locally Advanced ESCC Fudan University Recruiting 2026-01-07
NCT05865743 Perioperative SDD to Prevent Infectious Complications After Esophagectomy Radboud University Medical Center Recruiting 2025-03-05
NCT05055648 PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy University of Aarhus Recruiting 2024-12-17
NCT04513808 Total Intravenous Anesthesia and Recurrence Free Survival The Cleveland Clinic Recruiting 2024-12-04
NCT06339060 An Organ Preservation Strategies After Chemoradiotherapy Combined With Immunotherapy for… Ruijin Hospital Recruiting 2024-07-03
NCT04280822 Neo-adjuvant Immunochemotheray Versus Neo-adjuvant Chemotherapy for Resectable Esophageal… Henan Cancer Hospital Recruiting 2022-10-04
NCT05547529 The Efficacy of Neoadjuvant Chemoradiotherapy in Comparison With Neoadjuvant Chemotherapy… Blokhin's Russian Cancer Research Center Recruiting 2022-10-04
NCT05188313 TRAstuzumab and Pertuzumab for HER2+ Resectable Oesophageal Cancer Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Recruiting 2022-06-24
NCT04135664 Comparison of Esophagectomy and Chemoradiation for Patients With cN0-pT1b Stage… Shanghai Chest Hospital Recruiting 2019-10-22
NCT03731442 Salvage Chemoradiation Therapy for Recurrence After Radical Surgery or Palliative Surgery… Chinese Academy of Medical Sciences Recruiting 2018-12-12
NCT07788001 A Non-inferiority Study of Indocyanine Green-guided Sentinel Lymph Node Mapping Versus… Fujian Medical University Union Hospital Not Yet Recruiting 2026-08-26
NCT06914011 Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally… Asan Medical Center Not Yet Recruiting 2026-06-02
NCT06356311 A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic… Merck Sharp & Dohme LLC Active, Not Recruiting 2026-02-27
See all 440 active Esophageal Cancer trials with filters →

Top sponsors by active trials in this area

Cancer Institute and Hospital, Chinese Academy of Medical Sciences (11) · Fudan University (11) · M.D. Anderson Cancer Center (9) · National Cancer Institute (NCI) (9) · Memorial Sloan Kettering Cancer Center (8) · Henan Cancer Hospital (6) · Shanghai Chest Hospital (6) · Sun Yat-sen University (6) · Tianjin Medical University Cancer Institute and Hospital (6) · University Medical Center Groningen (6)

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