Perioperative FLOT(D) With Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Esophageal Cancer

The goal of this clinical trial is to learn the safety of the addition of PULSAR radiation to standard of care chemotherapy and immunotherapy in people with esophageal and gastroesophageal junction cancer and to determine the safest dose of radiation that can be used. Participants in this study will be undergoing clinically scheduled procedures. In addition to the standard of care visits and treatments, there will be additional visits and assessments with radiation.

NCT Number	NCT07700420
Lead Sponsor	University of Texas Southwestern Medical Center
Conditions	Gastro-esophageal Junction (GEJ) Cancer, Esophagus Cancer
Enrollment	15 participants
Start Date	2026-10-01
Primary Completion	2027-10-01 (estimated)
Study Completion	2031-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-14