Sponsor Pipeline

Children's Oncology Group Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
59
Active Trials
28
Recruiting
21
Phase 3
10
Disease Areas
18
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-10 NCT04158739
Flotetuzumab for the Treatment of Pediatric Recurrent or Refractory Acute Myeloid Leukemia
date change Completion pushed: 2026-03-31 -> 2026-12-31
2026-06-04 NCT00379340
Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients…
Trial completed
2026-06-04 NCT00379340
Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients…
date change Completion moved earlier: 2026-11-18 -> 2026-03-31
2026-06-04 NCT00352534
Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or…
Trial completed
2026-06-03 NCT07022678
Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With…
Recruitment opened
2026-06-03 NCT04903080
HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
date change Primary completion pushed: 2026-06-30 -> 2033-03-31
2026-06-03 NCT04903080
HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
date change Completion moved earlier: 2043-07-20 -> 2033-03-31
2026-06-03 NCT03033992
Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation…
date change Primary completion pushed: 2031-05-22 -> 2032-07-22
2026-06-03 NCT03033992
Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation…
date change Completion pushed: 2031-07-21 -> 2032-07-22
2026-06-03 NCT04978727
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade…
date change Primary completion pushed: 2027-04-30 -> 2027-12-31
2026-06-03 NCT04978727
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade…
date change Completion moved earlier: 2030-02-28 -> 2027-12-31
2026-05-23 NCT01190930
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk…
Trial completed
2026-05-21 NCT03817398
Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients…
date change Primary completion pushed: 2026-06-30 -> 2026-09-30
2026-05-21 NCT03817398
Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients…
date change Completion pushed: 2026-06-30 -> 2026-09-30
2026-05-20 NCT04903080
HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
date change Primary completion pushed: 2026-03-31 -> 2026-06-30
2026-05-19 NCT00082745
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors
Trial completed
2026-05-19 NCT05020951
Pilot Study to Enable Electronic Laboratory Data Transfer From Participating Institutions…
date change Completion pushed: 2026-03-31 -> 2026-06-30
2026-05-14 NCT05602194
Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for…
overall status: "Recruiting" → "Active Not Recruiting"
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-02 NCT07621614 A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children… Not Yet Recruiting
Active Trials by Phase
Phase 3
19
Phase 2/3
2
Phase 2
13
Phase 1/2
3
Phase 1
5
Not specified
17
Active Trials — top 25 of 59
NCT IDTitleConditionStatus
Phase 3
NCT03126916 Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With… Ganglioneuroblastoma Recruiting
NCT03067181 Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric… Childhood Extracranial Germ Cell Tumor Recruiting
NCT03959085 Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk… B Acute Lymphoblastic Leukemia Recruiting
NCT04293562 A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for… Acute Myeloid Leukemia Recruiting
NCT05235165 Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With… Metastatic Malignant Neoplasm in the Lung Recruiting
NCT05304585 Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low… Embryonal Rhabdomyosarcoma Recruiting
NCT05382338 A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss Childhood Medulloblastoma Recruiting
NCT05711667 A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell… Hematopoietic and Lymphoid Cell Neoplasm Recruiting
NCT06401330 A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology… Stage I Mixed Cell Type Kidney Wilms Tumor Recruiting
NCT06513962 Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With… Hematopoietic and Lymphatic System Neoplasm Recruiting
NCT06647953 Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary… Pleuropulmonary Blastoma Recruiting
NCT07022678 Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With… Acute Myeloid Leukemia Recruiting
NCT02339740 Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic… Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA Active, Not Recruiting
NCT04089358 Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young… Hematopoietic and Lymphoid Cell Neoplasm Active, Not Recruiting
NCT07466316 A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose… Rhabdomyosarcoma Not Yet Recruiting
NCT03007147 Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed… Acute Lymphoblastic Leukemia Active, Not Recruiting
NCT02176967 Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With… Ganglioneuroblastoma Active, Not Recruiting
NCT04994132 A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With… Alveolar Rhabdomyosarcoma Active, Not Recruiting
NCT05602194 Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for… B Acute Lymphoblastic Leukemia Active, Not Recruiting
Phase 2/3
NCT07072585 Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With… Stage II T Lymphoblastic Leukemia/Lymphoma Not Yet Recruiting
NCT06820957 Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing… CIC-Rearranged Sarcoma Active, Not Recruiting
Phase 2
NCT05504291 A Study to Give Treatment Inside the Eye to Treat Retinoblastoma Bilateral Retinoblastoma Recruiting
NCT06410209 A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for… Hematopoietic and Lymphatic System Neoplasm Recruiting
NCT06368817 A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma Basal Ganglia Germinoma Recruiting
NCT04322318 A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed… Anaplastic Kidney Wilms Tumor Recruiting
View all 59 active Children's Oncology Group trials with filters →
Disease Areas
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