Disease Landscape

Chronic Myeloid Leukemia (CML) Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-08-16
122
Active Trials
63
Recruiting
6
Phase 3
78
Sponsors
15
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-08-09 NCT06163430
A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and… · Terns, Inc.
Sponsor changed: Terns, Inc. -> Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
2026-08-09 NCT02061800
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell… · Diane George
overall status: Active, Not Recruiting → Unknown
2026-08-08 NCT07269470
Phase II Study Assessing the Safety and Efficacy of Dasatinib in Combination With… · M.D. Anderson Cancer Center
Recruitment opened
2026-08-08 NCT05092451
Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in… · M.D. Anderson Cancer Center
date change Primary completion pushed: 2026-08-31 -> 2030-08-31
2026-08-08 NCT05092451
Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in… · M.D. Anderson Cancer Center
date change Completion pushed: 2026-08-31 -> 2030-08-31
2026-07-29 NCT05362773
A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies · MacroGenics
Enrollment closed, study ongoing
2026-07-23 NCT03849651
TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use… · St. Jude Children's Research Hospital
date change Completion pushed: 2026-06-07 -> 2027-12-31
2026-07-23 NCT05143840
Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase · University of Alabama at Birmingham
overall status: Recruiting → Active, Not Recruiting
2026-07-21 NCT05589896
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased… · Ossium Health, Inc.
overall status: Recruiting → Active, Not Recruiting
2026-07-21 NCT05589896
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased… · Ossium Health, Inc.
date change Primary completion pushed: 2026-05-31 -> 2026-07-14
2026-07-21 NCT05589896
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased… · Ossium Health, Inc.
date change Completion pushed: 2027-03-31 -> 2029-05-31
2026-07-19 NCT07166419
Anti-CD19/20/22 Chimeric Antigen Receptor T Cells (TriCAR19.20.22 T Cells) for the… · Ohio State University Comprehensive Cancer Center
critical Recruitment suspended
2026-07-19 NCT07166419
Anti-CD19/20/22 Chimeric Antigen Receptor T Cells (TriCAR19.20.22 T Cells) for the… · Ohio State University Comprehensive Cancer Center
critical why stopped: — → On hold for review
2026-07-19 NCT03480360
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune… · Dartmouth-Hitchcock Medical Center
Trial completed
2026-07-19 NCT03480360
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune… · Dartmouth-Hitchcock Medical Center
date change Completion moved earlier: 2026-10-17 -> 2025-10-17
New Sponsor Entrants, Last 90 Days
First PostedTrialSponsorPhase
2026-08-11 NCT07758218 Allogeneic iNKT Cell Therapy (agenT-797) After SCT University of Wisconsin, Madison NEW Phase 1
2026-07-31 NCT07740603 Study of CD38 and CD56 in Chronic Myeloid Leukemia Sohag University NEW
2026-06-16 NCT07651878 Phase I Trial of Vididencel in CML-CP Patients With MRD Under TKI Treatment Mendus NEW Phase 1
2026-06-11 NCT07640750 Efficacy of Asciminib in Real-world in Patients With Chronic Myeloid Leukemia in Second… Gruppo Italiano Malattie EMatologiche dell'Adulto NEW
2026-06-10 NCT07638007 Impact of Targeted Therapy on Cancer-Related Cognitive Impairment University of Rochester NCORP Research Base NEW
Active Trials by Phase
Phase 4
1
Phase 3
6
Phase 2
44
Phase 1/2
8
Phase 1
24
Early Phase 1
2
Not specified
37
Active Trials — top 25 of 122
NCT IDTitleSponsorStatus
Phase 4
NCT05367765 A Real World Study of the Efficacy and Safety of Flumatinib Versus Imatinib in Patients… Jiangsu Hansoh Pharmaceutical Co., Ltd. Not Yet Recruiting
Phase 3
NCT03459534 A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure… Il-Yang Pharm. Co., Ltd. Recruiting
NCT06423911 Study of Olverembatinib (HQP1351) in Patients With CP-CML Ascentage Pharma Group Inc. Recruiting
NCT03722420 Randomized Evaluation of Radotinib Versus Imatinib in Phase III Study for Efficacy With… Il-Yang Pharm. Co., Ltd. Active, Not Recruiting
NCT05753384 Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and… Poitiers University Hospital Active, Not Recruiting
NCT05456191 A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib… Novartis Pharmaceuticals Active, Not Recruiting
NCT04971226 A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+… Novartis Pharmaceuticals Active, Not Recruiting
Phase 2
NCT03852407 Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy… University of Liege Recruiting
NCT06508099 Vitamin A and D Supplementation in Allogeneic HCT St. Petersburg State Pavlov Medical University Recruiting
NCT06532084 Sorafenib Relapase Prophylaxis After HCT With PTBCy Regimen St. Petersburg State Pavlov Medical University Recruiting
NCT06453902 TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) Patients Shenzhen TargetRx Co., Ltd. Recruiting
NCT06355583 Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial Imperial College London Recruiting
NCT06409936 PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CML Gruppo Italiano Malattie EMatologiche dell'Adulto Recruiting
NCT05884333 Cord Blood Transplant in Adults With Blood Cancers Memorial Sloan Kettering Cancer Center Recruiting
NCT05031897 Two Step Haplo With Radiation Conditioning Thomas Jefferson University Recruiting
NCT07238712 Optimization of Post-transplantation Benadamustine and Cyclophosphamide in Patients With… St. Petersburg State Pavlov Medical University Recruiting
NCT06059391 CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of… City of Hope Medical Center Recruiting
NCT06859424 A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based… Center for International Blood and Marrow Transplant Research Recruiting
NCT06368414 A Study of Treatment-free Remission in Chronic Phase Chronic Myeloid Leukemia Korean Society of Hematology Recruiting
NCT06514534 Open-label Study of Asciminib for CML-CP or CML-AP Patients With T315I Mutation Who Are… Novartis Pharmaceuticals Recruiting
NCT06817720 Phase II Study Assessing the Efficacy and Toxicity of Olverembatinib Monotherapy in… M.D. Anderson Cancer Center Recruiting
NCT04195633 Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for… Fred Hutchinson Cancer Center Recruiting
NCT05800210 Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in… University of Florida Recruiting
NCT06802315 Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen… University of Illinois at Chicago Recruiting
NCT02889003 Second STOP After Pioglitazone Priming in CML Patients Versailles Hospital Recruiting
See all 122 active Chronic Myeloid Leukemia (CML) trials with filters →
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