Clinical Trial

Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning

Study acronym: HLA
Recruiting Phase 2
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Summary
The present project aims at comparing two conditioning regimens (FM-PTCy vs FM-ATG). The hypothesis is that one or the two regimens will lead to a 2-year cGRFS rate improvement from 30% (the cGRFS rate with FM without ATG/PTCy) to 45% (Pick-a-winner phase 2 randomized study).
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2019-02-20; most recent amendment 2022-10-11.
Status change: Suspended → Recruiting 2020-09-09
Status change: Recruiting → Suspended 2019-09-30
Trial Details
NCT Number NCT03852407
Lead Sponsor University of Liege
Collaborators: Belgian Hematological Society
Conditions Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myeloid Leukemia in Remission, Myeloproliferative Syndrome, Myeloproliferative Disorder, Acute Lymphoid Leukemia in Remission, Multiple Myeloma, Chronic Lymphoid Leukemia +2 more
Enrollment 114 participants
Start Date 2019-02-04
Primary Completion 2033-11-01 (estimated)
Study Completion 2038-11-01 (estimated)
Updated on ClinicalTrials.gov 2022-10-12