Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

This phase III trial compares the effect of xylitol dental wipes to dental wipes without xylitol for the reduction of bloodstream infection in children with acute myeloid leukemia (AML). Xylitol is a naturally occurring sugar compound found in fruits and vegetables. Xylitol has been shown to limit the growth of bacteria in the mouth, and to reduce cavities, plaque on the teeth, and inflammation of the gums. Treatment for AML includes chemotherapy. Patients receiving chemotherapy for AML have a risk of developing bloodstream infections. Bloodstream infections can make patients very sick, can contribute to delays in treatment, and can even cause death. In AML patients, bacteria or fungus (yeast) can sometimes enter the bloodstream from the mouth. Using xylitol dental wipes may help to reduce bloodstream infections in children being treated for AML.

NCT Number	NCT07022678
Lead Sponsor	Children's Oncology Group
Conditions	Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Enrollment	556 participants
Start Date	2026-05-26
Primary Completion	2032-01-15 (estimated)
Study Completion	2033-01-15 (estimated)
Updated on ClinicalTrials.gov	2026-07-16