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A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

StatusActive, Not Recruiting
PhasePhase 1
SponsorPfizer
Started2022-07-05
View on ClinicalTrials.gov ↗
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07799933) administered as a single agent and in combination with other study medicines in people with solid tumors. This study is seeking participants who have an advanced solid tumor with a certain type of abnormal gene called "BRAF" and available treatments are no longer effective in controlling their cancer. All participants in this study will receive PF-07799933. PF-07799933 comes as a tablet to take by mouth, 2 times a day. Depending on the part of the study, participants may also receive another study medicine: * People with melanoma or other solid tumors may also receive binimetinib. Binimetinib comes as a tablet to take by mouth, 2 times a day. * People with colorectal cancer may also receive cetuximab or cetuximab and mFOLFOX6 (Chemotherapy regimen). Cetuximab will be given weekly (or every two weeks) in the clinic as a shot given in the vein or port (intravenous, IV). Participants may receive the study medicines for about 2 years. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.

Amendment history 10 changes detected by DataLookout

2026-09-02
notable
Enrollment closed, study ongoing
2026-09-02
minor
Final enrollment: 103 participants (planned 267)
2026-09-02
minor
Primary completion moved earlier: 2028-04-23 → 2027-08-31
2026-09-02
minor
Completion moved earlier: 2029-10-25 → 2027-08-31
2026-06-06
minor
Primary completion moved earlier: 2029-02-02 → 2028-04-23
2026-06-06
minor
Completion moved earlier: 2030-08-06 → 2029-10-25
2026-05-15
minor
Trial sites expanded: 18 → 40 locations
2026-05-06
minor
Trial sites reduced: 41 → 18 locations
2026-04-24
notable
Primary completion pushed: 2028-11-02 → 2029-02-02
2026-04-24
minor
Completion pushed: 2030-05-06 → 2030-08-06
Trial Details
NCT Number NCT05355701
Lead Sponsor Pfizer
Conditions Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma, Advanced Colorectal Cancer (Part 1)
Enrollment 103 participants
Start Date 2022-07-05
Primary Completion 2027-08-31 (estimated)
Study Completion 2027-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-09-01