Disease landscape

Endometrial Cancer clinical trials

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547 active trials 314 recruiting 44 Phase 3 306 sponsors 83 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-16

What changed in the last 30 days showing 44 of 83 changes on 20 trials

2026-09-11
Recruitment suspended
Recruitment suspended: Enrollment Goal Met
Completion moved earlier: 2027-05-22 → 2026-12-20
NCT04683653 Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer · University of Chicago · Phase 1/2
2026-09-16
Primary completion pushed: 2026-08-15 → 2026-12-15
NCT04585750 The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C… · PMV Pharmaceuticals, Inc · Phase 1/2
2026-09-15
Primary completion pushed: 2029-08 → 2030-08
Enrollment increased: 2020 → 2285 participants
Completion pushed: 2029-08 → 2030-08
NCT05059444 ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation · Guardant Health, Inc.
2026-09-05
Primary completion pushed: 2027-02 → 2029-06
Primary endpoint(s) modified
Enrollment increased: 495 → 575 participants
Interventions modified
Completion pushed: 2027-04 → 2029-06
Trial arms changed: 9 → 11
NCT06400472 A Study of Sofe-M in Participants With Selected Advanced Solid Tumors · Eli Lilly and Company · Phase 1
2026-09-11
Primary completion pushed: 2026-03-30 → 2028-03-30
Completion pushed: 2027-03-30 → 2028-03-30
NCT06379113 GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients · Xiaojun Chen · Phase 2/3
2026-09-11
Primary completion pushed: 2026-03-30 → 2028-03-30
Completion pushed: 2027-03-30 → 2028-03-30
NCT05316935 GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical… · Xiaojun Chen · Phase 2/3
2026-09-11
Primary completion pushed: 2026-09-30 → 2028-09-30
Completion pushed: 2026-09-30 → 2028-09-30
NCT02397083 Levonorgestrel-Releasing Intrauterine System With or Without Everolimus in Treating… · M.D. Anderson Cancer Center · Phase 2
2026-08-27
Primary completion pushed: 2028-12-31 → 2029-10-31
Completion pushed: 2029-12-31 → 2030-10-31
NCT07349641 A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to… · National Cancer Institute (NCI) · Phase 2
2026-09-04
Primary completion pushed: 2026-08 → 2027-04
NCT07194551 Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and… · University of British Columbia
2026-09-01
Primary completion pushed: 2027-06-30 → 2028-06-30
NCT04839614 Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With… · Dana-Farber Cancer Institute
2026-08-21
Primary completion pushed: 2026-09-23 → 2027-09-23
Completion pushed: 2026-09-23 → 2027-09-23
NCT04569773 Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer · Memorial Sloan Kettering Cancer Center
2026-09-03
Primary endpoint(s) modified
Trial completed
Primary completion confirmed: June 2026 (last estimated June 2027)
NCT05864144 A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in… · Sensei Biotherapeutics, Inc. · Phase 1/2
2026-08-22
Primary endpoint(s) modified
Recruitment opened
Enrollment increased: 56 → 299 participants
Trial sites expanded: 0 → 3 locations
Primary completion moved earlier: 2028-08 → 2027-08
Trial arms changed: 2 → 3
NCT07623369 A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors · Huahui Health · Phase 1
2026-08-21
Primary endpoint(s) modified
Trial arms changed: 4 → 5
NCT05269381 Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for… · Mayo Clinic · Phase 1/2
2026-09-05
Primary endpoint(s) modified
Results posted: 2026-09-04
NCT05139368 Hypofractionated Radiotherapy for the Treatment of Cervical or Endometrial Cancer · University of Utah
2026-09-15
Trial completed
Final enrollment: 33 participants (planned 30)
NCT05634499 A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer · Hoffmann-La Roche · Phase 2
2026-09-15
Enrollment closed, study ongoing
NCT05799274 Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other… · Radiopharm Theranostics, Ltd · Phase 1
2026-09-15
Trial completed
NCT05858736 Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors · OncoC4, Inc. · Phase 1
2026-09-03
Sponsor refiled this as recruiting (was completed)
NCT06904365 Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women · Washington University School of Medicine
2026-09-01
Recruitment opened
NCT07662824 Flyte Device for Improving Urinary Incontinence Among Endometrial and Cervical Cancer… · Mayo Clinic

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-15 NCT07820358 Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical… The Methodist Hospital Research Institute new Phase 2
2026-09-11 NCT07814872 A Preregistered Multi-Cohort Evaluation of the FATHOM AI System for Molecular Testing… Harvard Medical School (HMS and HSDM) new
2026-09-11 NCT07815951 Safety and Diagnostic Performance of 111In-TJD-31 SPECT Imaging in Patients With Solid… Yong He new Phase 1
2026-09-10 NCT07812636 Tirzepatide and Levonorgestrel IUD Therapy for EIN and Early-Stage Endometrial Cancer Milton S. Hershey Medical Center new Early Phase 1
2026-09-10 NCT07814248 A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of… TwoStep Therapeutics, Inc. new Phase 1
2026-09-08 NCT07808164 ENPP1/cGAS (EG) and FAP Expression Profiles in Solid Tumors: An Immunohistochemical Study… Tam Anh Research Institute new
2026-08-28 NCT07793318 TR115 in ARID1A-Mutated Advanced Solid Tumors Tarapeutics Science Inc. new Phase 2
2026-08-21 NCT07779109 Pelvic Ultra-Hypofractionated Adjuvant Radiotherapy for Endometrial Cancer (PURE-cohort) Instituto de Investigación Sanitaria Aragón new
2026-08-10 NCT07755436 Phase 1 Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and… ArriVent BioPharma, Inc. new Phase 1
2026-08-07 NCT07752875 A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53… LG Chem new Phase 1/2

Active trials by phase

Early Phase 1
10
Phase 1
85
Phase 1/2
52
Phase 2
120
Phase 2/3
10
Phase 3
34
Phase 4
7
Not charted: 229 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 547

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06726291 Akynzeo as Antiemetic Treatment in Patients With Endometrial Cancer Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Recruiting 2024-12-10
NCT02543710 Biomarker Guided Treatment in Gynaecological Cancer Haukeland University Hospital Recruiting 2017-03-28
NCT07281547 Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal… Mayo Clinic Not Yet Recruiting 2026-08-05
NCT07652515 A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Primary… GlaxoSmithKline Not Yet Recruiting 2026-06-17
NCT07462663 SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus… Hospital Universitari de Bellvitge Not Yet Recruiting 2026-06-10
NCT06897527 A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With… GlaxoSmithKline Not Yet Recruiting 2025-07-08
NCT06871787 Near-Infrared Fluorescence Imaging With Indocyanine Green to Evaluate Bowel Anastomoses… Istanbul University Not Yet Recruiting 2025-03-14
Phase 3
NCT04073706 Sentinel Node Biopsy in Endometrial Cancer Queensland Centre for Gynaecological Cancer Recruiting 2026-09-15
NCT05256225 Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2… National Cancer Institute (NCI) Recruiting 2026-09-11
NCT06952504 A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab… Merck Sharp & Dohme LLC Recruiting 2026-09-11
NCT07166094 Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's… Genmab Recruiting 2026-09-09
NCT07198074 Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin… National Cancer Institute (NCI) Recruiting 2026-09-04
NCT06989112 DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or… AstraZeneca Recruiting 2026-09-03
NCT06340568 A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy… BioNTech SE Recruiting 2026-09-01
NCT07286331 A Study to Investigate Mocertatug Rezetecan Compared With Chemotherapy in Participants… GlaxoSmithKline Recruiting 2026-08-31
NCT05646316 Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb… NRG Oncology Recruiting 2026-08-07
NCT07044336 Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial… AstraZeneca Recruiting 2026-07-29
NCT07022483 Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing… Daiichi Sankyo Recruiting 2026-07-28
NCT03785288 Vaginal Cuff Brachytherapy Fractionation Study Kara Romano, MD Recruiting 2026-04-22
NCT04789694 Prehabilitation in Gynaecological Cancer Patients Charles University, Czech Republic Recruiting 2026-03-19
NCT06712472 Randomized Phase III Trial Testing Maintenance Olaparib Versus Observation After Adjuvant… Gustave Roussy, Cancer Campus, Grand Paris Recruiting 2026-01-20
NCT03422198 Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II… University of Utah Recruiting 2025-12-12
NCT06584032 Study of Fruquintinib Plus Sintilimab for Treatment of Advanced Endometrial Cancer Hutchmed Recruiting 2025-01-07
NCT07684599 A Study to Investigate Mocertatug Rezetecan as Maintenance Treatment for Participants… GlaxoSmithKline Not Yet Recruiting 2026-09-01
NCT06132958 Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial… Merck Sharp & Dohme LLC Active, Not Recruiting 2026-08-28
See all 547 active Endometrial Cancer trials with filters →

Top sponsors by active trials in this area

National Cancer Institute (NCI) (24) · M.D. Anderson Cancer Center (21) · Mayo Clinic (15) · Memorial Sloan Kettering Cancer Center (14) · AstraZeneca (13) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (13) · Peking University People's Hospital (10) · Dana-Farber Cancer Institute (9) · GlaxoSmithKline (6) · Women's Hospital School Of Medicine Zhejiang University (6)

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