Disease landscape

Depression clinical trials

Get alerts when Depression trials change

2,087 active trials 1,177 recruiting 90 Phase 3 974 sponsors 368 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 66 of 368 changes on 20 trials

2026-08-28
Withdrawn before enrolling
Trial withdrawn: unable to obtain equipment needed for study
Enrollment reduced: 25 → 0 participants
NCT07553364 Auditory Stimulation for Insomnia and Depression · Wake Forest University Health Sciences
2026-07-30
Withdrawn before enrolling
Trial withdrawn: This study does not meet the clinical trial definition under FDAAA 801 / NIH policy - participants aren't prospectively...
Enrollment reduced: 20 → 0 participants
NCT07714889 Development of an Accessible Cognitive Behavioral Therapy Digital Therapeutic for… · Toivoa Inc
2026-08-13
Trial terminated
Trial terminated: Lack of funding
Enrollment reduced: 50 → 1 participants
Primary completion moved earlier: 2026-12 → 2026-07-01
Completion moved earlier: 2026-12 → 2026-07-15
NCT05803551 A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients · Mayo Clinic · Phase 2
2026-07-31
Trial terminated
Trial terminated: Funding withdrawn by sponsor.
Primary completion moved earlier: 2027-12 → 2026-07-15
Completion moved earlier: 2028-04 → 2026-07-15
NCT06843187 Lemborexant for the Treatment of Residual Insomnia in Major Depressive Disorder (MDD) · Unity Health Toronto · Phase 2
2026-07-30
Trial terminated
Trial terminated: Recruitment of chronic opioid users was substantially lower than anticipated despite extensive recruitment efforts; the...
Enrollment increased: 24 → 58 participants
Primary completion moved earlier: 2026-08-01 → 2026-03-23
Completion moved earlier: 2026-10-01 → 2026-03-23
NCT05338632 Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists · Leiden University Medical Center · Phase 1
2026-08-12
Trial terminated
Trial terminated: The study was terminated due to limited resources and the loss of key study personnel, which made completion of the pla...
Enrollment reduced: 60 → 14 participants
Primary completion moved earlier: 2028-04 → 2023-12-31
Completion moved earlier: 2028-12 → 2023-12-31
NCT05388110 SKY Breath Intervention · University of California, San Francisco
2026-08-11
Trial status changed: Completed → Terminated
Trial terminated: Recruitment halted prematurely due to recruitment timing and resources for the study not aligning.
NCT05619510 Pain Reduction Through Empowered Recovery (PRIME) Study · Johns Hopkins University
2026-07-30
Trial terminated
Trial terminated: The study stopped because the funding ended.
Primary completion moved earlier: 2032-12-30 → 2022-04-28
Completion moved earlier: 2032-12-30 → 2022-04-28
NCT04201106 A Neuroimaging Study of Open-label Placebo in Depressed Adolescents · University of California, San Francisco
2026-08-27
Primary completion pushed: 2025-10 → 2026-01-31
Completed without a posted recruiting period
Completion pushed: 2025-10 → 2026-01-31
NCT07081061 Clinical Outcomes of a Digital Mental Health Intervention for Moderate/Severe Depression… · Teladoc Health
2026-08-25
Primary completion pushed: 2027-12 → 2029-01
Primary endpoint(s) modified
Completion pushed: 2028-01 → 2029-03
NCT07282678 Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major… · Pulvinar Neuro, LLC
2026-08-28
Primary completion pushed: 2025-02 → 2030-09
Completion pushed: 2025-02 → 2030-12
NCT04569448 Brexpiprazole Treatment for Bipolar I Depression · Douglas Mental Health University Institute · Phase 3
2026-08-28
Primary completion pushed: 2026-06-30 → 2027-07-01
Completion pushed: 2026-07-31 → 2027-09-30
NCT05895747 5-HTP and Creatine for Depression R33 Phase · University of Utah · Phase 2
2026-08-28
Primary completion pushed: 2025-05-20 → 2026-04-28
Trial completed
Enrollment increased: 70 → 81 participants
Completion moved earlier: 2027-09-30 → 2026-04-28
NCT06398561 Peer-led Intervention for Individuals With Major Depression. · University of the Balearic Islands
2026-08-28
Primary completion pushed: 2025-06 → 2025-10-27
Enrollment reduced: 50 → 31 participants
Trial completed
Completion moved earlier: 2026-08 → 2025-10-27
NCT00590265 Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression · Douglas Mental Health University Institute
2026-08-28
Primary completion pushed: 2025-04-30 → 2027-01
Completion pushed: 2025-12-31 → 2027-03
NCT05965310 Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention · Henry Ford Health System
2026-08-28
Primary completion pushed: 2025-06-30 → 2025-12-06
Trial completed
Enrollment increased: 220 → 260 participants
Completion pushed: 2025-06-30 → 2026-04-14
NCT04426461 Approach-Avoidance, Computational Framework for Predicting Behavioral Therapy Outcome… · Laureate Institute for Brain Research, Inc.
2026-08-28
Primary completion pushed: 2026-06-01 → 2027-06-01
Completion pushed: 2026-06-30 → 2027-06-30
NCT06696001 Neuroscience of Psychotherapy for Depression · University of North Carolina, Chapel Hill
2026-08-15
Primary completion pushed: 2025-10 → 2026-02-28
Trial completed
Enrollment increased: 1000 → 1600 participants
Completion pushed: 2025-11 → 2026-02-28
NCT06809907 Kintsugi Voice Device Pivotal Study · Kintsugi Mindful Wellness, Inc.
2026-08-27
Primary completion pushed: 2026-02-19 → 2027-03
Enrollment closed, study ongoing
Completion pushed: 2026-08 → 2027-03
NCT05559749 Collaborative Care for Anxiety and Depression in Epilepsy · Wake Forest University Health Sciences
2026-08-27
Primary completion pushed: 2027-07-31 → 2027-12-01
Completion pushed: 2027-08-31 → 2027-12-31
NCT06238700 Study on Allopregnanolone and Depression in Women Across the Menopause Transition · Beth Israel Deaconess Medical Center

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-27 NCT07790627 Effect of Utilizing Virtual Reality With Pulmonary Rehabilitation on Depression in COPD… Imam Abdulrahman Bin Faisal University new
2026-08-27 NCT07790055 THE EFFECT OF MINDFULNESS IN INFLAMMATION MARKERS (IL-6, TNF-Α, CRP AND CORTISOL) AMONG… Natalia Dewi Wardani, MD new
2026-08-27 NCT07790731 Using a School-Based Depression Literacy Psychoeducation Program With AI Chatbot to… Chang Hsiu-Ju new
2026-08-26 NCT07787845 The Goal is to Examine the Impact of Doula-coordinated, Midwife-delivered Postpartum Care… University of South Carolina new
2026-08-25 NCT07786285 Adjunctive Probiotic Therapy in Major Depressive Disorder: A Randomized Controlled Trial… University Maribor new
2026-08-24 NCT07781293 Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder… Bukwang Pharmaceutical new Phase 3
2026-08-21 NCT07780695 Effect of Adapted Physical Activity on Emotion Regulation in People With Depressive… Centre Hospitalier Georges Mazurelle new
2026-08-20 NCT07776236 Remote Group Cognitive Behavioral Skills Training for Mexican University Students With… Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente new
2026-08-19 NCT07772531 A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder Bristol-Myers Squibb new Phase 2
2026-08-19 NCT07774559 Treatment With Repetitive Transcranial Magnetic Stimulation in Peripartal Depression Psychiatric University Hospital, Zurich new

Active trials by phase

Early Phase 1
17
Phase 1
36
Phase 1/2
26
Phase 2
147
Phase 2/3
16
Phase 3
74
Phase 4
75
Not charted: 1,696 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 2,087

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06103760 Positioning of Esketamine Treatment in the Real-world Management of Depression Royal North Shore Hospital Recruiting 2026-08-12
NCT07552246 Comparing Acupuncture With Medication to Reduce Depression, Anxiety and Comorbid Sleep… Duke Kunshan University Recruiting 2026-07-29
NCT06833788 Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum… Assistance Publique - Hôpitaux de Paris Recruiting 2026-06-23
NCT07266545 RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression… Mayo Clinic Recruiting 2026-06-22
NCT07105111 A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive… Neurocrine Biosciences Recruiting 2026-06-16
NCT05017311 Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D) Nova Scotia Health Authority Recruiting 2026-06-11
NCT06278779 Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant… The George Institute Recruiting 2026-05-29
NCT05976347 Identifying and Treating Depression in the Orthopaedic Trauma Population Wake Forest University Health Sciences Recruiting 2026-05-22
NCT04400266 Buspirone and Melatonin for Depression Following Traumatic Brain Injury Massachusetts General Hospital Recruiting 2026-05-06
NCT05004987 Aβ Dynamics in LLMD NYU Langone Health Recruiting 2026-05-06
NCT06748209 Establishing Mobile Transcranial Magnetic Stimulation Medical University of South Carolina Recruiting 2026-05-06
NCT07432815 Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined… Cairo University Recruiting 2026-05-05
NCT05892744 Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression University of Texas at Austin Recruiting 2026-05-01
NCT05282277 Examining the Effects of Estradiol on Neural and Molecular Response to Reward University of North Carolina, Chapel Hill Recruiting 2026-04-29
NCT07080723 Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment… Aalborg University Hospital Recruiting 2026-04-27
NCT06903819 Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients Texas Tech University Health Sciences Center Recruiting 2026-03-24
NCT07478796 TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children Poznan University of Medical Sciences Recruiting 2026-03-18
NCT05851898 Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following… Wake Forest University Health Sciences Recruiting 2026-03-12
NCT07076342 The Role of mGluR5 in CBT-I Stony Brook University Recruiting 2026-02-17
NCT07136714 Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder… Nordsjaellands Hospital Recruiting 2026-02-06
NCT06075771 Dopaminergic Therapy for Anhedonia - 2 Emory University Recruiting 2026-01-28
NCT07369102 Esketamine With or Without Integration Therapy for Treatment-Resistant Depression University of Puerto Rico Recruiting 2026-01-27
NCT05913947 Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9) Aalborg University Hospital Recruiting 2026-01-21
NCT07182890 Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With… Xijing Hospital of Digestive Diseases Recruiting 2026-01-05
NCT07187492 Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With… Xijing Hospital of Digestive Diseases Recruiting 2026-01-05
See all 2,087 active Depression trials with filters →

Top sponsors by active trials in this area

Massachusetts General Hospital (39) · Stanford University (25) · Medical University of South Carolina (24) · VA Office of Research and Development (22) · Centre for Addiction and Mental Health (20) · University of California, Los Angeles (18) · Weill Medical College of Cornell University (18) · Shanghai Mental Health Center (16) · Washington University School of Medicine (16) · University of California, San Diego (15)

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