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RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

StatusRecruiting
PhasePhase 4
Started2026-02-17
View on ClinicalTrials.gov ↗

Amendment history

2026-06-17
Study Status, Study Design, Arms and Interventions, Eligibility v2
Trial arms changed: 2 → 1
InterventionsBupropion extended release (Drug), Cariprazine (Augmentation Phase) (Drug), Vortioxetine (Drug)→Cariprazine (Augmentation Phase) (Drug), Vortioxetine (Drug)
Eligibility criteria+907 characters
Inclusion Criteria Participants must meet all the following criteria to be eligible for the study: Adult females and males, aged 18-65 years Must have the ca [...] d with MDD, BD-I, or BD-II, confirmed using the SCID-IV-CV. If a participant has already completed a structured diagnostic interview within the last 2 years or participated in any of the following studies and provided consent to use their information in future studies: (IRB 19-001722, IRB: 23-004500, IRB: 24-013228, IRB: 25-005856, IRB: 25-007244), those SCI [...] Symptom severity score on the Quick Inventory for Depressive [...] with one of these prima [...]
2026-02-19
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2025-12-31→confirmed 2026-02-17
Study sitesdetails revised at 1 of 1 site
2025-11-25
Original filing
Mayo Clinic
1,015 trials monitored
See 115 trials at risk
Depression
2,976 trials monitored
See 162 trials at risk
Bipolar Disorder
384 trials monitored
See 22 trials at risk
The purpose of this research is to understand how changes in RNA editing relate to treatment response in unipolar and bipolar depression.
Trial Details
NCT Number NCT07266545
Lead Sponsor Mayo Clinic
Conditions Unipolar Depression, Bipolar Depression
Enrollment 120 participants
Start Date 2026-02-17
Primary Completion 2028-12-31 (estimated)
Study Completion 2030-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-22