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NCT06696001 · ClinicalTrials.gov record · last posted 2026-08-27

Neuroscience of Psychotherapy for Depression

StatusRecruiting
PhaseNot applicable
Started2025-04-11
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from the ClinicalTrials.gov record
The goal of this study is to learn the extent to which client-therapist brain activity may synchronize during a psychosocial intervention for depression symptoms. The study will compare behavioral activation, a client-centered type of cognitive-behavioral therapy, to psychoeducation which delivers information on strategies to recover from depression symptoms. Participants will answer questions about their mental and physical health, attend one psychosocial intervention session receiving either Behavioral Activation or Psychoeducation with simultaneous brain activity measurement and complete follow up surveys two weeks and one month following the intervention.

Protocol amendment history 2 changes detected by DataLookout

2026-08-28
Primary completion pushed: 2026-06-01 → 2027-06-01
2026-08-28
Completion pushed: 2026-06-30 → 2027-06-30
Trial Details
NCT Number NCT06696001
Lead Sponsor University of North Carolina, Chapel Hill
Collaborators: Foundation of Hope, North Carolina
Conditions Depression
Enrollment 45 participants
Start Date 2025-04-11
Primary Completion 2027-06-01 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-27