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Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

Study acronym: SNRI
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary and study completion dates: Dec 2026 to Dec 2028v12
  2. Re-verified, no change to tracked fieldsv11
  3. Primary and study completion dates: Feb 2025 to Dec 2026v10
  4. Start date: Feb 12, 2024 to Apr 8, 2024v9
  5. Re-verified, no change to tracked fieldsv8
Show 6 earlier versionsHide 6 earlier versions
  1. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Feb 2024 to Feb 12, 2024
    • Site details revised
    v7
  2. Start date: Dec 2023 to Feb 2024v6
  3. Start date: Oct 2023 to Dec 2023
    • Primary and study completion dates: Dec 2024 to Feb 2025
    v5
  4. Start date: Aug 2023 to Oct 2023v4
  5. Start date: Jul 2023 to Aug 2023v3
  6. Start date: Jun 2023 to Jul 2023v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture. The main questions it aims to answer are: * What are the obstacles to enrolling patients and prescribing anti-depressants among older adults? * Is it possible to start prescribing SNRI medication upon discharge? * What is the prevalence of depressive symptoms amongst patients with different types of injuries and weightbearing status? * What is a transition of care plan for patients who have geriatric depression and require further care? Participants will: * Undergo screening using the Geriatric Depression Scale * Start on Duloxetine 30mg daily at time of discharge * Report medication compliance and complete re-screening monthly * Complete patient reported outcome measures and 3 months, 6 months, and 1 year * Receive a referral to behavioral health, primary care, or psychiatrist for evaluation if they screen positive at any timepoint
Trial Details
NCT Number NCT05851898
Lead Sponsor Wake Forest University Health Sciences
Conditions
(from sponsor)		 Depression in Old Age, Fragility Fracture
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov