Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)

This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of this study is to integrate clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome for patients experiencing a major depressive episode (MDE).

NCT Number	NCT05017311
Lead Sponsor	Nova Scotia Health Authority Collaborators: Unity Health Toronto, Centre for Addiction and Mental Health, McMaster University, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Dalhousie University, University of Michigan, Simon Fraser University, Ontario Shores Centre for Mental Health Sciences, University of Saskatchewan
Conditions	Major Depressive Disorder
Enrollment	400 participants
Start Date	2023-01-20
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-11