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Examining the Effects of Estradiol on Neural and Molecular Response to Reward

Study acronym: PEEPS
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. 2 versions Re-verified since Feb 24, 2025, no change to tracked fieldsv7-v8
  2. Completion date: Dec 31, 2027 to Dec 31, 2026v6
  3. Primary completion date: Dec 31, 2027 to Dec 31, 2026v5
  4. Primary and study completion dates: Dec 31, 2026 to Dec 31, 2027 Start date: Apr 1, 2022 to Apr 20, 2022v4 Show 1 more changeShow less
    • Start date: Apr 1, 2022 to Apr 20, 2022
  5. Primary and study completion dates: Apr 2027 to Dec 31, 2026v3
  6. Trial status: Not Yet Recruiting to Recruiting Primary and study completion dates: Mar 2027 to Apr 2027 · Start date changed from estimate of Mar 2022 to Apr 1, 2022 · Site details revisedv2 Show 3 more changesShow less
    • Primary and study completion dates: Mar 2027 to Apr 2027
    • Start date changed from estimate of Mar 2022 to Apr 1, 2022
    • Site details revised
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).
Trial Details
NCT Number NCT05282277
Lead Sponsor University of North Carolina, Chapel Hill
Collaborators: National Institute of Mental Health (NIMH)
Conditions Depression, Psychosis, Anhedonia
Enrollment 103 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov