Clinical Trial

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

Study acronym: PEEPS
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2022-03-07; most recent amendment 2026-04-28.
Status change: Not Yet Recruiting → Recruiting 2022-04-21
Trial Details
NCT Number NCT05282277
Lead Sponsor University of North Carolina, Chapel Hill
Collaborators: National Institute of Mental Health (NIMH)
Conditions Depression, Psychosis, Anhedonia
Enrollment 103 participants
Start Date 2022-04-20
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-29