Disease landscape

CAR clinical trials

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20,318 active trials 10,894 recruiting 1,357 Phase 3 5,263 sponsors 2,721 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 65 of 2721 changes on 20 trials

2026-08-28
Withdrawn before enrolling
Trial withdrawn: Change in company strategy.
Enrollment reduced: 50 → 0 participants
NCT07529899 Evaluate the Efficacy and Safety of Amnion Membrane Disc Allograft vs Standard of Care in… · Cellution Biologics · Phase 4
2026-08-22
Reclassified as terminated (was completed)
Trial terminated: Trial was rendered as cancelled work ongoing in the book of business.
NCT04949256 Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus… · Merck Sharp & Dohme LLC · Phase 3
2026-08-21
Trial terminated
Trial terminated: Limited clinical activity
Trial sites reduced: 17 → 1 locations
NCT06315491 A Study of CBX 12 in Subjects With Platinum Resistant or Refractory Ovarian Cancer · Cybrexa Therapeutics · Phase 2
2026-08-28
Withdrawn before enrolling
Trial withdrawn: Other - Protocol moved to Withdrawn
Enrollment reduced: 24 → 0 participants
NCT06982222 Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have… · National Cancer Institute (NCI) · Phase 1
2026-08-18
Trial status changed: Enrolling by Invitation → Terminated
Trial terminated: Primary efficacy endpoint was not met in the parent study (ACP-101-302). Based on review of available data, continued a...
Primary completion moved earlier: 2029-05 → 2025-12-19
Completion moved earlier: 2029-06 → 2025-12-19
NCT06420297 OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi… · ACADIA Pharmaceuticals Inc. · Phase 3
2026-08-19
Suspended trial terminated
NCT05435014 T-ACE Oil by TAE/TACE in Patients With Hepatocellular Carcinoma · T-ACE Medical Co., Ltd · Phase 1/2
2026-08-25
Recruitment suspended
Recruitment suspended: Unacceptable Toxicity
NCT06620302 Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment… · Children's Oncology Group · Phase 1/2
2026-08-22
Trial status changed: Not Yet Recruiting → Terminated
Trial terminated: Inadequate study design which restricted study enrollment suitable for a registry.
Primary completion pushed: 2023-10 → 2024-07-09
Enrollment reduced: 600 → 24 participants
Completion moved earlier: 2027-10 → 2024-07-09
NCT05536310 TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve… · JenaValve Technology, Inc.
2026-07-31
Trial terminated
Trial terminated: Sponsor Decision
Primary endpoint(s) modified
Enrollment reduced: 849 → 72 participants
Primary completion moved earlier: 2026-10-31 → 2026-04-30
Completion moved earlier: 2027-07-31 → 2026-06-30
NCT05747794 Study in Metastatic Breast Cancer Patients Receiving Eftilagimod Alpha or Placebo in… · Immutep S.A.S. · Phase 2/3
2026-08-27
Withdrawn before enrolling
Trial withdrawn: Not enough time to complete study within reasonable timeframe
Enrollment reduced: 20 → 0 participants
Primary completion moved earlier: 2027-06-30 → 2026-09-01
Completion moved earlier: 2027-06-30 → 2026-09-01
NCT07431541 Topical Carboxytherapy Paste Following Microneedling · Vanderbilt University Medical Center · Phase 1/2
2026-08-07
Trial terminated
Trial terminated: Sponsor Decision - terminated due to changes in company priorities and not related to safety concerns.
Completion moved earlier: 2026-09-30 → 2026-07-21
NCT06736262 A Phase 2, Open-Label, Extension Study to Evaluate Long Term Safety and Clinical Activity… · Jasper Therapeutics, Inc. · Phase 2
2026-08-04
Trial status changed: Completed → Terminated
Trial terminated: Study was closed early as the sponsor decided not to continue development of certain treatment combinations.
NCT03869190 Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and… · Hoffmann-La Roche · Phase 1/2
2026-08-25
Trial terminated
Primary completion moved earlier: 2029-12-31 → 2026-07-01
Completion moved earlier: 2030-12-31 → 2026-07-31
NCT04430530 4SCAR-T Therapy Post CD19-targeted Immunotherapy · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-25
Trial terminated
Primary completion moved earlier: 2028-12-31 → 2026-07-01
Completion moved earlier: 2029-12-31 → 2026-07-31
NCT07193966 NG2 and DLL3 CAR-T Cells Targeting Melanoma · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-25
Trial terminated
Primary completion moved earlier: 2026-12-31 → 2026-07-01
Completion moved earlier: 2030-12-31 → 2026-07-31
NCT05437341 PSMA/CD70 Bi-specific CAR-T Cell Therapy · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-25
Trial terminated
Primary completion moved earlier: 2028-07-31 → 2026-07-01
Completion moved earlier: 2029-12-31 → 2026-07-31
NCT04010877 Multiple CAR-T Cell Therapy Targeting AML · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-25
Trial terminated
Primary completion moved earlier: 2029-12-31 → 2026-07-01
Completion moved earlier: 2030-12-31 → 2026-07-31
NCT03356795 Intervention of CAR-T Against Cervical Cancer · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-25
Trial terminated
Primary completion moved earlier: 2029-12-31 → 2026-07-01
Completion moved earlier: 2030-12-31 → 2026-07-31
NCT05437328 GD2/CD56 Bi-specific CAR-T Cell Therapy · Shenzhen Geno-Immune Medical Institute · Phase 1/2
2026-08-27
Withdrawn before enrolling
Trial withdrawn: Strategic adjustment.
Enrollment reduced: 10 → 0 participants
Primary completion moved earlier: 2028-10-31 → 2026-03-30
Completion moved earlier: 2028-10-31 → 2026-03-30
NCT07338357 Clinical Study of CLL-1 CAR-T in the Treatment of Children With R/R AML · First Affiliated Hospital of Guangxi Medical University · Early Phase 1
2026-08-25
Trial terminated
Primary completion moved earlier: 2029-12-31 → 2026-07-01
Completion moved earlier: 2030-12-31 → 2026-07-31
NCT04427449 4SCAR-CD44v6 T Cell Therapy Targeting Cancer · Shenzhen Geno-Immune Medical Institute · Phase 1/2

Active trials by phase

Early Phase 1
388
Phase 1
1,303
Phase 1/2
880
Phase 2
3,023
Phase 2/3
195
Phase 3
1,162
Phase 4
522
Not charted: 12,845 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 20,318

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07218211 Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using… Duke University Recruiting 2026-08-26
NCT07746336 Treatment Based on High Precision Cardiac Mapping Hospital Clinic of Barcelona Recruiting 2026-08-25
NCT07780812 Evaluation of Speech and Voice Biomarkers in Association With Burnout Minneapolis Heart Institute Foundation Recruiting 2026-08-24
NCT07221617 Oral Methadone in Cardiac Surgery Mayo Clinic Recruiting 2026-08-21
NCT06862219 A Safety Study of Enfortumab Vedotin in Indian Adults With Urothelial Cancer Astellas Pharma Global Development, Inc. Recruiting 2026-08-21
NCT04667494 Ultrasound Therapy In Cardiac Amyloidosis Brigham and Women's Hospital Recruiting 2026-08-21
NCT05585125 A Preliminary Study for INFORMED Weill Medical College of Cornell University Recruiting 2026-08-21
NCT06881927 Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients… University Hospital, Strasbourg, France Recruiting 2026-08-20
NCT07776054 Clinical Impact of SGLT2 Inhibitor After DC Cardioversion in Persistent AF With HFpEF Samsung Medical Center Recruiting 2026-08-20
NCT04715568 Secondhand Tobacco Smoke and Cardiovascular Disease University of California, San Francisco Recruiting 2026-08-19
NCT06909565 Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb… Duke University Recruiting 2026-08-18
NCT07491367 Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two… University of California, San Francisco Recruiting 2026-08-18
NCT07503925 THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health Ohio State University Comprehensive Cancer Center Recruiting 2026-08-17
NCT06306300 Safety and Efficacy of Decentralized HCV Treatment vs Standard-of-Care in Rio de Janeiro… Oswaldo Cruz Foundation Recruiting 2026-08-17
NCT06651970 Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL… AstraZeneca Recruiting 2026-08-14
NCT06578234 Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses Region Skane Recruiting 2026-08-13
NCT06084234 National Liver Cancer Screening Trial University of Texas Southwestern Medical Center Recruiting 2026-08-12
NCT07486713 Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies Rigel Pharmaceuticals Recruiting 2026-08-11
NCT07426484 Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy Dana-Farber Cancer Institute Recruiting 2026-08-11
NCT07178145 Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction University of Virginia Recruiting 2026-08-11
NCT05180773 Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy Dennis M. McNamara, MD, MS Recruiting 2026-08-10
NCT05812755 SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery Vanderbilt University Medical Center Recruiting 2026-08-06
NCT06674109 SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial Massachusetts General Hospital Recruiting 2026-08-05
NCT07745062 The Effectiveness of Systane PRO Preservative Free Verses Blink Triple Care Preservative… Gordon Schanzlin New Vision Recruiting 2026-08-04
NCT06637332 Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia Todd C. Lee MD MPH FIDSA Recruiting 2026-07-31
See all 20,318 active CAR trials with filters →

Top sponsors by active trials in this area

National Cancer Institute (NCI) (344) · M.D. Anderson Cancer Center (343) · Sun Yat-sen University (237) · Mayo Clinic (225) · Assistance Publique - Hôpitaux de Paris (177) · Memorial Sloan Kettering Cancer Center (165) · City of Hope Medical Center (145) · Cairo University (137) · Assiut University (136) · Fudan University (127)

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