Sponsor pipeline

Roche / Genentech clinical trial pipeline

Get alerts when Roche / Genentech's trials change

255 active trials 99 recruiting 94 Phase 3 47 disease areas 124 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-02

What changed in the last 30 days showing 52 of 124 changes on 20 trials

2026-10-02
Primary completion pushed: 2026-11-27 → 2028-02-05
Enrollment increased: 240 → 330 participants
Trial sites reduced: 50 → 46 locations
Completion pushed: 2026-11-27 → 2028-02-05
Trial arms changed: 9 → 12
NCT07112872 A Study to Compare Different Doses of RO7795081 With Placebo or Semaglutide in People… · Phase 2
2026-09-24
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2026-06-30 → 2027-06-30
NCT02650401 Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or… · Phase 1/2
2026-09-15
Primary completion pushed: 2027-02-19 → 2028-04-20
Enrollment closed, study ongoing
Trial sites reduced: 352 → 311 locations
NCT06065748 A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a… · Phase 3
2026-09-04
Primary completion pushed: 2026-10-31 → 2027-06-30
Trial sites reduced: 164 → 161 locations
Completion pushed: 2026-10-31 → 2027-06-30
NCT03178552 A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments… · Phase 2/3
2026-09-12
Primary completion pushed: 2031-07-31 → 2032-04-30
Completion pushed: 2031-07-31 → 2032-04-30
NCT07226206 A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A · Phase 1/2
2026-09-05
Primary completion pushed: 2026-09-30 → 2027-12-31
Completion pushed: 2026-09-30 → 2027-12-31
NCT06274515 A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies · Phase 4
2026-09-12
Primary completion pushed: 2026-12-31 → 2030-06-17
Primary endpoint(s) modified
Enrollment closed, study ongoing
Enrollment increased: 40 → 240 participants
Interventions modified
Completion pushed: 2026-12-31 → 2030-06-17
Trial arms changed: 2 → 3
NCT07342114 A Clinical Study to Evaluate the Effects of RO7875913 in Healthy Participants and of… · Phase 1
2026-09-09
Primary completion pushed: 2028-10-30 → 2029-10-30
Completion pushed: 2029-04-30 → 2030-02-28
NCT06862869 Real World Clinical Outcomes of Resected ALK-Positive Early Stage NSCLC Patients Treated…
2026-10-02
Primary endpoint(s) modified
NCT05199688 A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, and… · Phase 3
2026-09-29
Primary endpoint(s) modified
Results posted: 2026-09-28
Trial sites reduced: 148 → 141 locations
NCT04660344 A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk… · Phase 3
2026-09-10
Primary endpoint(s) modified
Results posted: 2026-09-09
NCT04958265 A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of… · Phase 3
2026-09-09
Primary endpoint(s) modified
NCT07158242 A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121)… · Phase 3
2026-09-04
Phase changed: Phase 2 → Phase 3
NCT07503340 A Study to Evaluate Pharmacokinetics, Safety, Tolerability, Immunogenicity and… · Phase 3
2026-09-22
Phase changed: Phase 1/2 → Phase 1
Trial completed
NCT06693908 A Study to Evaluate the Activity, and Safety of Vixarelimab in Participants With Moderate… · Phase 1
2026-10-01
Trial completed
Trial sites expanded: 155 → 216 locations
Study completion confirmed: August 2026 (last estimated August 2027)
NCT02486718 Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best… · Phase 3
2026-09-26
Enrollment closed, study ongoing
Final enrollment: 1101 participants (planned 800)
Primary completion moved earlier: 2028-06-07 → 2028-02-16
Completion moved earlier: 2028-06-07 → 2028-02-16
NCT07169578 A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease · Phase 3
2026-09-26
Enrollment closed, study ongoing
Trial sites reduced: 150 → 147 locations
Final enrollment: 1060 participants (planned 800)
Primary completion moved earlier: 2028-06-07 → 2028-02-16
Completion moved earlier: 2028-06-07 → 2028-02-16
NCT07170150 A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease · Phase 3
2026-10-01
Enrollment closed, study ongoing
NCT05954910 A Study to Evaluate the Effectiveness and Safety of Polatuzumab in Real World Clinical…
2026-09-29
Recruitment opened
NCT07827586 Non-interventional Study of Subcutaneous Ocrelizumab in Persons With Relapsing-Remitting…
2026-09-30
Primary completion pushed: 2027-10-31 → 2027-12-31
Trial sites reduced: 202 → 198 locations
NCT05296798 A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo… · Phase 3

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-10-01 NCT07851259 A Study to Assess the Efficacy and Safety of RO7965032 in Participants With Geographic… Phase 2 Not Yet Recruiting
2026-09-29 NCT07846683 A Study to Assess the Efficacy and Safety of Afimkibart for Induction Therapy in… Phase 3 Not Yet Recruiting
2026-09-28 NCT07843472 A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants… Phase 3 Not Yet Recruiting
2026-09-28 NCT07843485 A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants… Phase 3 Not Yet Recruiting
2026-09-28 NCT07843498 A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants… Phase 3 Not Yet Recruiting
2026-09-24 NCT07838194 Clinical Trial of NXT007 for the Prophylactic Treatment of Hemophilia A in Infants and… Phase 3 Not Yet Recruiting
2026-09-22 NCT07835243 A Study to Assess the Effect of Subcutaneous Injection Site on the Pharmacokinetics of… Phase 1 Not Yet Recruiting
2026-09-18 NCT07827573 A Study to Learn How Well Participants With a Specific Type of Early Breast Cancer… Phase 3 Not Yet Recruiting
2026-09-18 NCT07827586 Non-interventional Study of Subcutaneous Ocrelizumab in Persons With Relapsing-Remitting… Recruiting
2026-09-18 NCT07827599 A Study to Confirm Efficacy of a Single Dose of Baloxavir Marboxil in the Post-exposure… Phase 3 Not Yet Recruiting

Active trials by phase

Phase 1
54
Phase 1/2
25
Phase 2
52
Phase 2/3
4
Phase 3
90
Phase 4
10
Not charted: 20 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 255

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07609719 A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple… Multiple Sclerosis Recruiting 2026-09-30
NCT05861999 A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric… Muscular Atrophy, Spinal Recruiting 2026-09-10
NCT06274515 A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies Breast Cancer Recruiting 2026-09-04
NCT05861986 A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early… Muscular Atrophy, Spinal Recruiting 2026-09-03
NCT04853251 A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related… Neovascular Age-related Macular Degeneration Recruiting 2026-09-02
NCT07483450 A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of… Relapsing Multiple Sclerosis Active, Not Recruiting 2026-09-30
NCT05232929 Long-term Follow-up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA) Spinal Muscular Atrophy Active, Not Recruiting 2026-09-09
NCT05224102 A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented… Diabetic Macular Edema Active, Not Recruiting 2026-08-25
NCT06795048 A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants… Neovascular Age-related Macular Degeneration (nAMD) Active, Not Recruiting 2026-07-31
NCT05181618 A Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants… Severe Hemophilia A Active, Not Recruiting 2026-07-27
Phase 3
NCT05199688 A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, and… Neuromyelitis Optica Spectrum Disorder Recruiting 2026-10-01
NCT03683251 Extension Study for the Port Delivery System With Ranibizumab (Portal) Neovascular Age-Related Macular Degeneration Recruiting 2026-09-28
NCT05646862 A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With… Breast Cancer Recruiting 2026-09-28
NCT06819891 A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart… Moderately to Severely Active Crohns Disease Recruiting 2026-09-28
NCT06094010 A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants… Influenza Recruiting 2026-09-24
NCT07416526 A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in… Hemophilia A Recruiting 2026-09-23
NCT05894239 A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo… Metastatic Breast Cancer Recruiting 2026-09-21
NCT06847542 A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD Neovascular Age-related Macular Degeneration Recruiting 2026-09-21
NCT07177352 Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's… Alzheimers Disease Recruiting 2026-09-21
NCT06819878 A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With… Moderately to Severely Active Crohns Disease Recruiting 2026-09-16
NCT07351045 A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With… Obesity or Overweight Recruiting 2026-09-14
NCT07351058 A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With… Obesity or Overweight Recruiting 2026-09-14
NCT07541079 A Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes of Giredestrant… Early Breast Cancer Recruiting 2026-09-14
NCT07555938 Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in… Multiple Myeloma Recruiting 2026-09-11
NCT07670416 A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or… Obesity Recruiting 2026-09-10
See all 255 active Roche / Genentech trials with filters →

Disease areas by active trials, top 10 of 47

Breast Cancer (29) · Multiple Sclerosis (24) · Lung Cancer (18) · Non-Small Cell Lung Cancer (NSCLC) (17) · Non-Hodgkin Lymphoma (13) · Obesity (11) · Multiple Myeloma (10) · Alzheimer's Disease (8) · Liver Cancer (8) · Diabetes (7)

Get alerts when Roche / Genentech's trials change
Status changes, date slips, and new filings: detected daily, delivered to your inbox.
Start monitoring free