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A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Established Cardiovascular Disease

Name: A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Established Cardiovascular Disease — clinical trial record (NCT07843472)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: ZUPREME-5

StatusNot Yet Recruiting

PhasePhase 3

SponsorHoffmann-La Roche

Started2026-09-30

View on ClinicalTrials.gov ↗

Roche/Genentech

364 trials monitored

See 34 trials at risk

Obesity

3,523 trials monitored

See 133 trials at risk

Heart Disease

2,117 trials monitored

See 101 trials at risk

This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or obesity and established cardiovascular disease (CVD).

Trial Details

NCT Number	NCT07843472
Lead Sponsor	Hoffmann-La Roche Collaborators: Zealand Pharma
Conditions	Obesity or Overweight, Cardiovascular Disease
Enrollment	2,500 participants
Start Date	2026-09-30
Primary Completion	2030-07-28 (estimated)
Study Completion	2030-10-06 (estimated)
Updated on ClinicalTrials.gov	2026-09-28