Atrial Fibrillation clinical trials
Data updated daily from ClinicalTrials.gov, last refresh 2026-11-05
What changed in the last 30 days
76 trials changed in the last 30 days: 1 stopped, 40 with notable changes, 35 with minor changes only.
- Notable: DualSmart · Dual Energy THERMOCOOL SMARTTOUCH™ SF Catheter With TRUPULSE™ Generator in Persistent Atrial Fibrillation Recruitment opened
- Notable: GreatPFA · Varipulse Catheter · Paroxysmal Atrial Fibrillation Under Optimized Sedation Recruitment opened
- Minor: FEATHER · Arrhythmia Mapping With a Multi-Electrode Mapping Catheter Primary completion pushed from Sep 30, 2026 to Feb 7, 2027
- Notable: Atrial Fibrillation Patients Treated With Catheter Ablation Primary completion pushed from Oct 1, 2025 to Oct 1, 2027
- Notable: ENVIsIoN · Catheter Ablation Using a Novel Navigation and Imaging System Start date pushed from Jan 1, 2027 to Mar 1, 2027
- Notable: ENLIgHT · Registry on Luma Vision's VERAFEYE System Start date pushed from May 15, 2027 to Dec 15, 2027
- Notable: SPECTRA-AF · Predict Atrial Fibrillation (AF) Burden · PAF and PsAF Treated With the VARIPULSE™ PFA Catheter Start date pushed from Oct 30, 2026 to Apr 14, 2027
- Notable: PARADISO · Paroxysmal Atrial Fibrillation Repeat Ablation Strategies With Durably Isolated Pulmonary Veins Start date pushed from Sep 2026 to Dec 2026
- Minor: VP-EXTRA · VARIPULSE Catheter and TRUPULSE Generator With VARIPULSE PRO Software · PsAF Enrollment closed, study ongoing
- Minor: INSiGHT · VERAFEYE Imaging and Navigation System for Guided Catheter Ablation Procedures Primary and study completion pushed from Oct 15, 2026 to Dec 15, 2026
- Minor: TIMERS-1 · Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation Enrollment closed, study ongoing
- Minor: PERSIGMA RCT · VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter · Persistent Atrial Fibrillation Trial sites expanded: 10 → 20 locations
- Notable: RAFTING-GIB · Resumption of Anticoagulation After Major Gastrointestinal Bleeding · Atrial Fibrillation Primary endpoint(s) modified
- Minor: AFCOG · Acute Cognitive Changes During Atrial Fibrillation Episodes Trial completed
- Notable: VOLT CE Mark Study Primary completion pushed from Jun 2026 to Jan 2027
- Notable: AI-Based Cardiac Analysis Using 12-Lead and 1-Lead ECG Recruitment opened
- Minor: PIVCO · Pulsed-field Ablation · Persistent Atrial Fibrillation Trial completed
- Notable: PRIME-AF · Cardiac Rehabilitation Needs · Atrial Fibrillation Sponsor changed: Odense University Hospital to Esbjerg Hospital - University Hospital of Southern Denmark
- Minor: ARIADNE RCT · ARIADNE Clinical Trial Enrollment closed, study ongoing
- Minor: BURST-AF · Coherent Sine Burst (CSE) Electroporation System Pilot Study · Atrial Fibrillation Trial completed
- Stopped: terminated, suspended or withdrawn
- Notable: the plan changed
- Minor: routine updates
New sponsor entrants, last 90 days sponsors with their first trial in this area
| First posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-10-29 | NCT07902739 Pulsed Field Ablation of Atrial Fibrillation: CENTAURI Versus FARAPULSE | St. Anne's University Hospital Brno, Czech Republic new | |
| 2026-10-28 | NCT07901699 Resumption of Anticoagulation After Major Gastrointestinal Bleeding in Patients With… | Società Italiana di Medicina Interna new | |
| 2026-10-28 | NCT07900685 A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under… | East Sussex Healthcare NHS Trust new | |
| 2026-10-26 | NCT07893821 Renal Denervation in Patients With Atrial Fibrillation and Hypertension | Pavel Antiperovitch new | |
| 2026-10-16 | NCT07877116 Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial… | Hüseyin Ulaş Pinar new | Phase 4 |
| 2026-10-15 | NCT07874763 Bachmann's Bundle Versus Right Atrial Appendage Pacing | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) new | |
| 2026-10-13 | NCT07870889 Vortosiran in Atrial Fibrillation | Ribocure Pharmaceuticals AB new | Phase 2 |
| 2026-10-08 | NCT07865221 Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: Clinical Efficacy and Left… | Tianjin Medical University General Hospital new | |
| 2026-10-05 | NCT07857044 Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities | Christina Berr. MD new | |
| 2026-09-30 | NCT07849777 Early Anticoagulation Therapy After Endovascular Treatment for Acute Ischemic Stroke With… | Hao Yonggang new |
Active trials by phase
| Early Phase 1 | 4 | |
| Phase 1 | 3 | |
| Phase 1/2 | 4 | |
| Phase 2 | 18 | |
| Phase 2/3 | 6 | |
| Phase 3 | 40 | |
| Phase 4 | 72 |
Not charted: 842 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).
Top sponsors by active trials in this area
Beijing Anzhen Hospital (23) · Yonsei University (21) · Boston Scientific Corporation (19) · China National Center for Cardiovascular Diseases (14) · Medtronic Cardiac Ablation Solutions (11) · Ottawa Heart Institute Research Corporation (11) · The Cleveland Clinic (11) · Assistance Publique - Hôpitaux de Paris (10) · Biosense Webster, Inc. (10) · National Taiwan University Hospital (10)
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