PAfOSASNCT07857044

Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities

StatusRecruiting

PhaseNot specified

SponsorChristina Berr. MD

Primary completionDec 31, 2028 (estimated)

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Record History

All 1 version: 1 with changes below.

Sep 30, 2026 Study First Submitted

Endpoints

Primary

quantification of area of left-atrial fibrosis in the heart

Timeframe: baseline

Rate of recurrence of atrial fibrillation (yes/no) in the study group

Timeframe: 1 year after procedure (ablation)

Arms and interventions

Diagnostic tests: Screening on comorbidites

Sites

1 site in 1 country

University hospital AugsburgAugsburg, Bavaria, Germany

About this trial

Pulmonary vein isolation is an established intervention for atrial fibrillation. Patients with a paroxysmal atrial fibrillation have no or only few comorbidities and a good prognosis in respect to their atrial fibrillation. In contrast, patients with persistent atrial fibrillation often suffer from relevant comorbidities and recurrence of atrial fibrillation is common. Left-atrial fibrosis and its electrophysiological consequences are involved in the recurrence rate, but pathophysiological mechanisms are yet to be better characterized. The study investigates relevant comorbidities to elucidated their effect on atrial fibrosis and recurrence rates of atrial fibrillation. Furthermore, the investigators evaluate the prevalence of these comorbidities.

Trial details

Enrollment: 200 participants (estimated)
Started: Mar 31, 2023
Study completion: Dec 31, 2029 (estimated)
Eligibility: 18 and older, all sexes, no healthy volunteers
Design: Observational
Oversight: Data monitoring committee
Conditions: Atrial Fibrillation, Hyperaldosteronism, Sleep Apnea Syndromes, Sleep Apnea, Primary Aldosteronism
Official title: Left-atrial Fibrosis in Persistent Atrial Fibrillation, Sleep Apnoe and Primary Aldosteronism
First posted: Oct 5, 2026
Registry updated: Oct 5, 2026
Last verified: Sep 2026

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