Skip to content
DataLookout
Start free
Menu

TIMERS-1NCT07139301

Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation

StatusActive, Not Recruiting
PhaseNot applicable
Primary completion (estimated)

At risk: Primary completion moved at least 4 months later.

See at-risk trials from Capital Medical University

Track this trial

Free. We email you which fields changed when ClinicalTrials.gov updates this record.

Record History

All 6 versions: 6 with changes below. See every version on ClinicalTrials.gov ↗

  1. Enrollment closed, study ongoing Show 5 more changesShow less
    • Primary completion pushed from Aug 31, 2026 to Jan 17, 2027
    • Study completion pushed from Aug 31, 2026 to Oct 18, 2027
    • Eligibility criteria expanded, about 33 words
    • Secondary endpoints: details revised at 3 of 13 entries
    • Site details revised at 40 of 40 sites
  2. Secondary endpoints: 12 to 13v5
  3. Study sites: 9 to 40v4
  4. Study sites: 2 to 9
    • Start date changed from estimate of Aug 26, 2025 to Sep 4, 2025
    v3
  5. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 1 to 2
    • Start date: Aug 20, 2025 to Aug 26, 2025
    • Secondary endpoints: details revised at 1 of 12 entries
    v2
  6. Study First Submitted
  • Notable: the plan changed
  • Minor: routine updates

Endpoints

Primary

Composite outcome of recurrent ischemic stroke, symptomatic intracranial hemorrhage, and all-cause death
Timeframe: 90 days

Secondary (13)

Incidence of recurrent ischemic stroke
Incidence of venous thromboembolism
Incidence of systemic embolism
Incidence of myocardial infarction
Proportion of Patients Achieving mRS 0-1
Show 8 moreShow less
Proportion of Patients Achieving mRS 0-2
Length of hospital stay for stroke-related care
Quality of life assessed by EuroQol 5 Dimensions 5 level questionnaire [EQ-5D-5L]
Incidence of vascular death
All-cause mortality
Incidence of symptomatic intracranial haemorrhage (sICH)
Incidence of major extracranial bleeding
Composite outcome of recurrent ischemic stroke, symptomatic intracranial hemorrhage, and all-cause death

Arms and interventions

Early anticoagulationExperimental

Early initiation of any direct oral anticoagulant (DOAC) within 96 hours (4 days) of the onset of acute ischemic stroke

Delayed anticoagulationActive comparator

Delayed initiation of any direct oral anticoagulant (DOAC) between 5-14 days of the onset of acute ischemic stroke

Drugs: Early anticoagulation, Delayed anticoagulation

Sites

40 sites in 1 country