Sponsor Pipeline

National Heart, Lung, and Blood Institute (NHLBI) Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
83
Active Trials
56
Recruiting
1
Phase 3
10
Disease Areas
7
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-02 NCT05998408
JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure
overall status: "Recruiting" → "Active Not Recruiting"
2026-06-02 NCT05998408
JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure
Enrollment reduced: 145 -> 13 participants
2026-05-29 NCT03312400
Low-Dose Danazol for the Treatment of Telomere Related Diseases
overall status: "Recruiting" → "Active Not Recruiting"
2026-05-29 NCT03312400
Low-Dose Danazol for the Treatment of Telomere Related Diseases
Enrollment reduced: 40 -> 18 participants
2026-05-29 NCT05904093
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in…
date change Primary completion pushed: 2026-05-14 -> 2027-05-14
2026-05-29 NCT05904093
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in…
date change Completion pushed: 2026-05-14 -> 2027-05-14
2026-05-16 NCT03312400
Low-Dose Danazol for the Treatment of Telomere Related Diseases
date change Primary completion pushed: 2026-04-29 -> 2027-04-29
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-05-29 NCT07613099 Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation… Phase 3 Not Yet Recruiting
2026-05-20 NCT07599176 Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors Phase 1/2 Recruiting
Active Trials by Phase
Phase 4
1
Phase 3
1
Phase 2
10
Phase 1/2
12
Phase 1
7
Early Phase 1
3
Not specified
49
Active Trials — top 25 of 83
NCT IDTitleConditionStatus
Phase 4
NCT05170399 Vaccine Responses in Patients With B Cell Malignancies Lymphoma Recruiting
Phase 3
NCT07613099 Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation… Allogeneic Stem Cell Transplantation Not Yet Recruiting
Phase 2
NCT03986034 Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic… Chronic Lymphocytic Leukemia Recruiting
NCT04304820 Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive… Severe Aplastic Anemia Recruiting
NCT06923072 Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological… Kohlmeier-Degos Disease Recruiting
NCT01174108 Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other… Severe Aplastic Anemia Recruiting
NCT03520647 Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH… Severe Aplastic Anemia (SAA) Recruiting
NCT03372733 Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults Cardiovascular Disease Recruiting
NCT02979873 Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia… Severe Aplastic Anemia Active, Not Recruiting
NCT02514083 A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL Chronic Lymphocytic Leukemia Active, Not Recruiting
NCT01500733 PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Leukemia Active, Not Recruiting
NCT03312400 Low-Dose Danazol for the Treatment of Telomere Related Diseases Telomere Disease Active, Not Recruiting
Phase 1/2
NCT04008368 Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease… Myeloid Chimerism Recruiting
NCT03173937 Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and… Severe Aplastic Anemia Recruiting
NCT06032923 Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With… Systemic Lupus Erythematosus (Sle) Recruiting
NCT01799538 Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis Lymphangioleiomyomatosis Recruiting
NCT07599176 Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors Sickle Cell Disease Recruiting
NCT05357482 Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell… Sickle Cell Anemia Active, Not Recruiting
NCT01623167 Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia Severe Aplastic Anemia Active, Not Recruiting
NCT00977691 Haploidentical PBMC Transplant for Severe Congenital Anemias Sickle Cell Anemia Active, Not Recruiting
NCT03077542 Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell… Sickle Cell Disease Active, Not Recruiting
NCT06145282 Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease… Sickle Cell Disease Active, Not Recruiting
NCT04610866 Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat… Sickle Cell Disease Active, Not Recruiting
NCT05998408 JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure Severe Aplastic Anemia Active, Not Recruiting
Phase 1
NCT05904093 Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in… Sickle Cell Disease Recruiting
View all 83 active National Heart, Lung, and Blood Institute (NHLBI) trials with filters →
Disease Areas
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