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Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

StatusRecruiting
PhasePhase 1/2
Started
View on ClinicalTrials.gov ↗

Record History

See every version on ClinicalTrials.gov ↗

  1. Eligibility criteria shortened, about 31 words
    • Study description expanded, about 6 words
  2. 2 versions Re-verified since Jul 28, 2026, no change to tracked fieldsv33-v34
  3. Start date changed from estimate of Jul 15, 2026 to Jul 8, 2026v32
  4. Start date: Jul 14, 2026 to Jul 15, 2026v31
  5. Start date: Jul 13, 2026 to Jul 14, 2026
    • Eligibility criteria expanded, about 3 words
    v30
Show 28 earlier versionsHide 28 earlier versions
  1. Start date: Jul 12, 2026 to Jul 13, 2026v29
  2. Start date: Jul 8, 2026 to Jul 12, 2026v28
  3. Start date: Jul 7, 2026 to Jul 8, 2026v27
  4. Start date: Jul 6, 2026 to Jul 7, 2026v26
  5. Start date: Jul 5, 2026 to Jul 6, 2026v25
  6. Start date: Jul 2, 2026 to Jul 5, 2026v24
  7. Start date: Jul 1, 2026 to Jul 2, 2026v23
  8. Start date: Jun 30, 2026 to Jul 1, 2026v22
  9. Start date: Jun 29, 2026 to Jun 30, 2026v21
  10. Start date: Jun 28, 2026 to Jun 29, 2026v20
  11. Start date: Jun 24, 2026 to Jun 28, 2026v19
  12. Start date: Jun 23, 2026 to Jun 24, 2026v18
  13. Start date: Jun 22, 2026 to Jun 23, 2026v17
  14. Start date: Jun 21, 2026 to Jun 22, 2026v16
  15. Start date: Jun 18, 2026 to Jun 21, 2026v15
  16. Start date: Jun 17, 2026 to Jun 18, 2026v14
  17. Start date: Jun 16, 2026 to Jun 17, 2026v13
  18. Start date: Jun 15, 2026 to Jun 16, 2026v12
  19. Start date: Jun 14, 2026 to Jun 15, 2026v11
  20. Start date: Jun 11, 2026 to Jun 14, 2026v10
  21. Start date: Jun 10, 2026 to Jun 11, 2026v9
  22. Start date: Jun 9, 2026 to Jun 10, 2026v8
  23. Start date: Jun 8, 2026 to Jun 9, 2026v7
  24. Start date: Jun 7, 2026 to Jun 8, 2026v6
  25. Start date: Jun 4, 2026 to Jun 7, 2026v5
  26. Start date: Jun 3, 2026 to Jun 4, 2026v4
  27. Start date: Jun 2, 2026 to Jun 3, 2026v3
  28. Start date: Jun 1, 2026 to Jun 2, 2026v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a non-ablative (partial) stem cell transplant for patients with severe sickle cell disease or beta-thalassemia requiring red cell transfusions. The intensity of the transplant is slightly increased from our previous transplant regimens. The goal is to aim for higher percentage of donor cells to stably remain in the recipients long term.
Trial Details
NCT Number NCT07599176
Lead Sponsor National Heart, Lung, and Blood Institute (NHLBI)
Conditions
(from sponsor)		 Sickle Cell Disease, Beta-thalassemia
Related terms Anemia, Sickle Cell, beta-Thalassemia
Enrollment 90 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov