Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

This is a non-ablative (partial) stem cell transplant for patients with severe sickle cell disease or beta-thalassemia requiring red cell transfusions. The intensity of the transplant is slightly increased from our previous transplant regimens. The goal is to aim for higher percentage of donor cells to stably remain in the recipients long term.

NCT Number	NCT07599176
Lead Sponsor	National Heart, Lung, and Blood Institute (NHLBI)
Conditions	Sickle Cell Disease, Beta-thalassemia
Enrollment	90 participants
Start Date	2026-07-08
Primary Completion	2032-06-30 (estimated)
Study Completion	2035-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-13