Sickle Cell Disease clinical trials

18 trials changed in the last 30 days: 1 stopped, 8 with notable changes, 9 with minor changes only.

1. Stopped

   ProTIP · Prophylactic Transfusion In Pregnant · Sickle Cell…ProTIP · Prophylactic Transfusion In Pregnant · Sickle Cell Disease

   Trial status changed: Recruiting → Withdrawn

   Also in this update: Trial arms changed: 2 → 3

   Emory University·Phase 4· NCT06979492· Registry history of NCT06979492 on ClinicalTrials.gov (opens the registry)

   Oct 19, 2026

2. Notable

   KID-BID · Twice Daily Dosing Regimen of Hydroxycarbamide…KID-BID · Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets · Sickle Cell Disease

   Primary and study completion pushed from Feb 2027 to Feb 2028

   Theravia·Phase 2· NCT06578507· Registry history of NCT06578507 on ClinicalTrials.gov (opens the registry)

   Oct 1, 2026

3. Notable

   Nicotinamide With Oral Tetrahydrouridine and Decitabine · High…Nicotinamide With Oral Tetrahydrouridine and Decitabine · High Risk Sickle Cell Disease

   Primary completion pushed from Oct 30, 2026 to Oct 30, 2028

   Also in this update: Study completion pushed from Apr 30, 2027 to Jan 20, 2029

   EpiDestiny, Inc.·Phase 1· NCT04055818· Registry history of NCT04055818 on ClinicalTrials.gov (opens the registry)

   Sep 30, 2026

4. Notable

   PRESENCE · Peer Support for Adolescents and Emerging · Sickle…PRESENCE · Peer Support for Adolescents and Emerging · Sickle Cell Pain

   Primary completion pushed from Jul 2027 to Feb 2028

   Also in this update: Enrollment reduced: 470 → 390 participants; Study completion pushed from May 2028 to Aug 2028

   University of Pittsburgh·Not applicable· NCT06374238· Registry history of NCT06374238 on ClinicalTrials.gov (opens the registry)

   Oct 8, 2026

5. Notable

   Project REACH · Exercise in Child Health

   Primary and study completion pushed from Jun 30, 2026 to Dec 31, 2027

   University of California, Irvine·Not applicable· NCT05359991· Registry history of NCT05359991 on ClinicalTrials.gov (opens the registry)

   Oct 2, 2026

6. Notable

   Glucose Metabolism in Sickle Cell Disease

   Primary completion pushed from Aug 1, 2026 to Aug 1, 2028

   Also in this update: Study completion pushed from Aug 1, 2026 to Aug 1, 2029

   University of Illinois at Chicago·Not specified· NCT02922296· Registry history of NCT02922296 on ClinicalTrials.gov (opens the registry)

   Sep 21, 2026

7. Notable

   Oral Ketamine · Vaso-Occlusive Pain

   Phase changed: Phase 3 → Phase 1

   Also in this update: Trial completed; Primary completion date changed from estimate of Jun 2026 to Nov 21, 2025

   Boston Children's Hospital·Phase 1· NCT05378555· Registry history of NCT05378555 on ClinicalTrials.gov (opens the registry)

   Sep 28, 2026

8. Notable

   RELIEVE-SCD · Virtual Reality for SCD VOC

   Recruitment opened

   Also in this update: Enrollment increased: 25 → 50 participants; Primary completion pushed from Aug 2027 to Dec 2027

   University of Maryland, Baltimore·Not applicable· NCT07674277· Registry history of NCT07674277 on ClinicalTrials.gov (opens the registry)

   Oct 16, 2026

9. Notable

   STEP · Integrating Point of Care Testing (POCT) For Newborn…STEP · Integrating Point of Care Testing (POCT) For Newborn Screening and Early Care for Sickle Cell Disease in Yopougon, Côte d'Ivoire

   Recruitment opened

   Swiss Tropical & Public Health Institute·Phase 4· NCT07488520· Registry history of NCT07488520 on ClinicalTrials.gov (opens the registry)

   Oct 5, 2026

• Stopped: an ongoing trial was terminated, suspended or withdrawn.
• Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
• Minor: routine progress and housekeeping, such as sites added or enrollment closed.