| Detected | Trial | Change |
|---|---|---|
| 2026-08-14 | NCT03653338 T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD)… · Paul Szabolcs |
date change Primary completion pushed: 2026-08-01 -> 2028-08-01 |
| 2026-08-14 | NCT03653338 T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD)… · Paul Szabolcs |
date change Completion pushed: 2027-08-01 -> 2028-08-01 |
| 2026-08-13 | NCT05777993 A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… · Agios Pharmaceuticals, Inc. |
Primary endpoint(s) modified |
| 2026-08-13 | NCT05777993 A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… · Agios Pharmaceuticals, Inc. |
Enrollment increased: 6 -> 59 participants |
| 2026-08-13 | NCT05777993 A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… · Agios Pharmaceuticals, Inc. |
Trial sites expanded: 4 -> 23 locations |
| 2026-08-12 | NCT06743113 Hypoxic Red Blood Cells in Sickle Cell Anemia · Hemanext |
date change Primary completion pushed: 2028-04 -> 2029-04 |
| 2026-08-12 | NCT06743113 Hypoxic Red Blood Cells in Sickle Cell Anemia · Hemanext |
date change Completion pushed: 2028-09 -> 2029-10 |
| 2026-08-09 | NCT04310059 Effect of Folic Acid Supplementation in Pregnant Women Having Thalassaemia Trait · The University of Hong Kong |
overall status: Not Yet Recruiting → Unknown |
| 2026-08-07 | NCT07673302 Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia · Riphah International University |
Recruitment opened |
| 2026-08-04 | NCT07517133 A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… · Agios Pharmaceuticals, Inc. |
Recruitment opened |
| 2026-08-04 | NCT07506863 A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… · Agios Pharmaceuticals, Inc. |
Recruitment opened |
| 2026-08-01 | NCT04691323 The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit… · Ann & Robert H Lurie Children's Hospital of Chicago |
Trial completed |
| 2026-08-01 | NCT04691323 The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit… · Ann & Robert H Lurie Children's Hospital of Chicago |
date change Primary completion moved earlier: 2025-06-01 -> 2024-06-18 |
| 2026-08-01 | NCT04691323 The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit… · Ann & Robert H Lurie Children's Hospital of Chicago |
date change Completion moved earlier: 2025-12-01 -> 2025-05-29 |
| 2026-08-01 | NCT04688411 An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell… · Ann & Robert H Lurie Children's Hospital of Chicago |
Trial completed |
| 2026-08-01 | NCT04688411 An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell… · Ann & Robert H Lurie Children's Hospital of Chicago |
Enrollment reduced: 40 -> 36 participants |
| 2026-08-01 | NCT04688411 An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell… · Ann & Robert H Lurie Children's Hospital of Chicago |
date change Primary completion pushed: 2025-02-01 -> 2025-09-16 |
| 2026-08-01 | NCT04688411 An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell… · Ann & Robert H Lurie Children's Hospital of Chicago |
date change Completion pushed: 2025-02-01 -> 2025-09-16 |
| 2026-07-29 | NCT07003269 Observational Study: Hetrombopag for Platelet Recovery in Haploidentical HSCT · Haikou Affiliated Hospital of Central South University Xiangya School of Medicine |
overall status: Enrolling by Invitation → Completed |
| 2026-07-29 | NCT07003256 Observational Study: Romiplostim for Platelet Recovery in Haploidentical HSCT · Haikou Affiliated Hospital of Central South University Xiangya School of Medicine |
overall status: Enrolling by Invitation → Completed |
| First Posted | Trial | Sponsor | Phase |
|---|---|---|---|
| 2026-07-23 | NCT07721480 Gene Therapy for Patients With Transfusion-Dependent β-Thalassemia | Prince of Wales Hospital, Shatin, Hong Kong NEW | Phase 2 |
| 2026-07-13 | NCT07698080 Dexamethasone, Intravenous Injection of Human Immunoglobulin, and Increased Infusion of… | Hematology department of the 920th hospital NEW | Phase 2 |
| 2026-07-02 | NCT07680803 Gene-Modified Stem Cell Therapy for Subjects With Transfusion-dependent Beta-thalassemia | Fondazione Telethon NEW | Phase 2 |
| 2026-06-29 | NCT07673302 Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia | Riphah International University NEW | |
| 2026-06-22 | NCT07660224 The Effect of Motivational Interviewing on Treatment Adherence and Self-Efficacy Among… | Oman Ministry of Health NEW | |
| 2026-05-29 | NCT07614217 Oral Health Status in Children With β-Thalassemia Major | Cairo University NEW |
| NCT ID | Title | Sponsor | Status |
|---|---|---|---|
| Phase 4 | |||
| NCT07177300 | Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations… | Children's Hospital Medical Center, Cincinnati | Recruiting |
| NCT02386800 | CINC424A2X01B Rollover Protocol | Novartis Pharmaceuticals | Active, Not Recruiting |
| NCT05777993 | A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… | Agios Pharmaceuticals, Inc. | Enrolling by Invitation |
| Phase 3 | |||
| NCT05477563 | Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With… | Vertex Pharmaceuticals Incorporated | Recruiting |
| NCT04064060 | A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other… | Celgene | Recruiting |
| NCT07506863 | A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… | Agios Pharmaceuticals, Inc. | Recruiting |
| NCT07517133 | A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… | Agios Pharmaceuticals, Inc. | Recruiting |
| NCT06609226 | A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle… | Novo Nordisk A/S | Recruiting |
| NCT07157722 | Evaluating the Effect of N-Acetyl Cysteine and Alpha Lipoic Acid in Patients With Beta… | Tanta University | Not Yet Recruiting |
| NCT05356195 | Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With… | Vertex Pharmaceuticals Incorporated | Active, Not Recruiting |
| NCT04770753 | A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With… | Agios Pharmaceuticals, Inc. | Active, Not Recruiting |
| NCT04770779 | A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With… | Agios Pharmaceuticals, Inc. | Active, Not Recruiting |
| NCT04208529 | A Long-term Follow-up Study in Participants Who Received CTX001 | Vertex Pharmaceuticals Incorporated | Enrolling by Invitation |
| Phase 2 | |||
| NCT06657391 | Evaluation of Recombinant Humanized Anti-CD25 Monoclonal Antibody for Preventing… | Rongrong Liu | Recruiting |
| NCT06490627 | Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta… | National Institute of Blood and Marrow Transplant (NIBMT), Pakistan | Recruiting |
| NCT04099966 | AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell… | Mitchell Cairo | Recruiting |
| NCT05693909 | A Trial Testing SP-420 in Subjects With Transfusion-dependent β-thalassemia or Low-risk… | Pharmacosmos A/S | Recruiting |
| NCT07338344 | Evaluating the Clinical Efficacy and Safety of Luspatercept Combined With Thalidomide in… | Rongrong Liu | Recruiting |
| NCT06302491 | A Study of Safety and Efficiency of AND017 in Patients With β-thalassemia | Kind Pharmaceuticals LLC | Recruiting |
| NCT07175051 | Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2… | University of Illinois at Chicago | Recruiting |
| NCT05736419 | A Study of Immune Suppression Treatment for People With Sickle Cell Disease or… | Memorial Sloan Kettering Cancer Center | Recruiting |
| NCT04143724 | Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta… | Celgene | Recruiting |
| NCT07680803 | Gene-Modified Stem Cell Therapy for Subjects With Transfusion-dependent Beta-thalassemia | Fondazione Telethon | Recruiting |
| NCT02105766 | Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation… | National Heart, Lung, and Blood Institute (NHLBI) | Active, Not Recruiting |
| NCT06490601 | Long Term Beta Thalassemia Treatment: Findings From The Extension Period | National Institute of Blood and Marrow Transplant (NIBMT), Pakistan | Active, Not Recruiting |