| Detected | Trial | Change |
|---|---|---|
| 2026-08-13 | NCT05777993 A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… |
Primary endpoint(s) modified |
| 2026-08-13 | NCT05777993 A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… |
Enrollment increased: 6 -> 59 participants |
| 2026-08-13 | NCT05777993 A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… |
Trial sites expanded: 4 -> 23 locations |
| 2026-08-05 | NCT07656415 A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With… |
Recruitment opened |
| 2026-08-05 | NCT07656415 A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With… |
Trial sites expanded: 0 -> 3 locations |
| 2026-08-04 | NCT07517133 A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… |
Recruitment opened |
| 2026-08-04 | NCT07506863 A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… |
Recruitment opened |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 4 | |||
| NCT05777993 | A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… | Pyruvate Kinase Deficiency | Enrolling by Invitation |
| Phase 3 | |||
| NCT07506863 | A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… | Transfusion-dependent Alpha-Thalassemia | Recruiting |
| NCT07517133 | A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… | Non-Transfusion-dependent Alpha-Thalassemia | Recruiting |
| NCT07656415 | A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With… | Sickle Cell Disease | Recruiting |
| NCT05144256 | A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With… | Pediatric Pyruvate Kinase Deficiency | Active, Not Recruiting |
| NCT05175105 | A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With… | Pediatric Pyruvate Kinase Deficiency | Active, Not Recruiting |
| NCT04770753 | A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With… | Non-Transfusion-dependent Alpha-Thalassemia | Active, Not Recruiting |
| NCT04770779 | A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With… | Transfusion-dependent Alpha-Thalassemia | Active, Not Recruiting |
| Phase 2/3 | |||
| NCT05031780 | A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With… | Sickle Cell Disease | Active, Not Recruiting |
| Phase 2 | |||
| NCT03692052 | A Study to Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of… | Thalassemia | Active, Not Recruiting |
| NCT06924970 | A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With… | Sickle Cell Disease | Active, Not Recruiting |
| NCT05490446 | A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk… | Myelodysplastic Syndromes | Active, Not Recruiting |
| Phase 1 | |||
| NCT07241234 | A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of… | Phenylketonuria | Recruiting |
| NCT07075640 | A Study to Determine the Safety and Tolerability of AG-236 and How it is Absorbed, Broken… | Healthy Participants | Active, Not Recruiting |
| Not specified | |||
| NCT03481738 | Pyruvate Kinase Deficiency Global Longitudinal Registry | Pyruvate Kinase Deficiency | Active, Not Recruiting |