Sponsor pipeline

Agios Pharmaceuticals, Inc. clinical trial pipeline

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16 active trials 4 recruiting 9 Phase 3 3 disease areas

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-11

What changed in the last 30 days

First postedNew trial filingPhaseStatus
2026-10-05 NCT07859423 A Study to Investigate AG-236 in Subjects ≥18 Years of Age With Polycythemia Vera Phase 2/3 Not Yet Recruiting

Active trials by phase

Phase 1
2
Phase 2
3
Phase 2/3
2
Phase 3
7
Phase 4
1
Not charted: 1 active trial with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials

NCT IDTitleConditionStatusUpdated
Phase 4
NCT05777993 A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an… Pyruvate Kinase Deficiency Enrolling by Invitation 2026-09-29
Phase 3
NCT07506863 A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… Transfusion-dependent Alpha-Thalassemia Recruiting 2026-09-28
NCT07517133 A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in… Non-Transfusion-dependent Alpha-Thalassemia Recruiting 2026-09-28
NCT07656415 A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With… Sickle Cell Disease Recruiting 2026-09-28
NCT04770753 A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With… Non-Transfusion-dependent Alpha-Thalassemia Active, Not Recruiting 2026-09-28
NCT04770779 A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With… Transfusion-dependent Alpha-Thalassemia Active, Not Recruiting 2026-09-28
NCT05144256 A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With… Pediatric Pyruvate Kinase Deficiency Active, Not Recruiting 2026-09-28
NCT05175105 A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With… Pediatric Pyruvate Kinase Deficiency Active, Not Recruiting 2026-08-27
Phase 2/3
NCT07859423 A Study to Investigate AG-236 in Subjects ≥18 Years of Age With Polycythemia Vera Polycythemia Vera Not Yet Recruiting 2026-10-05
NCT05031780 A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With… Sickle Cell Disease Active, Not Recruiting 2026-06-23
Phase 2
NCT05490446 A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk… Myelodysplastic Syndromes Active, Not Recruiting 2026-09-28
NCT06924970 A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With… Sickle Cell Disease Active, Not Recruiting 2026-09-28
NCT03692052 A Study to Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of… Thalassemia Active, Not Recruiting 2026-03-30
Phase 1
NCT07241234 A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of… Phenylketonuria Recruiting 2026-09-28
NCT07075640 A Study to Determine the Safety and Tolerability of AG-236 and How it is Absorbed, Broken… Healthy Participants Active, Not Recruiting 2026-07-30
Not specified
NCT03481738 Pyruvate Kinase Deficiency Global Longitudinal Registry Pyruvate Kinase Deficiency Active, Not Recruiting 2026-09-28

Disease areas by active trials

Thalassemia (6) · Sickle Cell Disease (4) · Myelodysplastic Syndromes (MDS) (1)

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