Sponsor pipeline

Sanofi / Regeneron clinical trial pipeline

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182 active trials 85 recruiting 59 Phase 3 21 disease areas 43 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 35 of 43 changes on 20 trials

2026-08-14
Withdrawn before enrolling
Trial withdrawn: Sponsor decision. Not related to safety concern.
Enrollment reduced: 20 → 0 participants
NCT07484230 A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab… · Phase 3
2026-08-15
Trial status changed: Completed → Terminated
Trial terminated: Sponsor decision based on limited clinical benefit observed in both Multiple Myeloma and Non-Hodgkin Lymphoma cohorts
NCT04401020 First-in-human Single Agent Study of SAR442257 in RRMM and RR-NHL · Phase 1
2026-08-14
Primary endpoint(s) modified
Enrollment increased: 150 → 230 participants
NCT06192563 A Study to Observe How Pediatric Patients With Severe Atopic Dermatitis Despite Less…
2026-08-28
Enrollment reduced: 636 → 464 participants
Enrollment closed, study ongoing
NCT06241118 A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background… · Phase 3
2026-08-13
Enrollment reduced: 380 → 59 participants
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Primary completion moved earlier: 2028-12-12 → 2027-02-17
Completion moved earlier: 2028-12-12 → 2027-02-17
NCT07424144 An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in… · Phase 3
2026-08-11
Enrollment reduced: 140 → 109 participants
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-05-17 → 2026-06-10
Completion moved earlier: 2028-11-20 → 2027-10-31
NCT06290128 A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory… · Phase 3
2026-08-28
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Enrollment increased: 1663 → 1856 participants
NCT05492578 Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous… · Phase 2/3
2026-08-26
Trial completed
NCT06691113 A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab… · Phase 2
2026-08-29
Recruitment opened
Trial sites expanded: 0 → 3 locations
NCT07612878 The Study of Chronic Obstructive Pulmonary Disease (COPD) Participants Treated With…
2026-08-14
Trial status changed: Recruiting → Enrolling by Invitation
NCT06191315 Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic… · Phase 3
2026-08-11
Recruitment opened
NCT07688213 A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With… · Phase 2
2026-08-11
Trial completed
NCT07634692 An Observational Study to Assess Nirsevimab Immunization Rates in Eligible Infants During…
2026-08-07
Primary completion pushed: 2026-07-10 → 2026-09-03
Completion pushed: 2026-10-02 → 2026-11-24
NCT05039840 Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus… · Phase 2
2026-09-01
Results posted: 2026-08-31
NCT05326412 Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD · Phase 2
2026-09-03
Trial sites reduced: 146 → 128 locations
Completion pushed: 2027-03-23 → 2027-10-22
NCT05405166 SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM · Phase 3
2026-08-19
Enrollment increased: 671 → 751 participants
NCT07185009 A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants… · Phase 3
2026-08-27
Trial sites expanded: 129 → 135 locations
NCT06290141 A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of… · Phase 3
2026-08-21
Trial sites expanded: 191 → 219 locations
NCT07184996 An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants… · Phase 3
2026-08-15
Trial sites expanded: 34 → 38 locations
NCT07325292 Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous… · Phase 3
2026-08-27
Trial sites expanded: 11 → 14 locations
NCT07457580 Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of…

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-08-28 NCT07793409 A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants… Phase 3 Not Yet Recruiting
2026-08-21 NCT07779408 Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at… Phase 1/2 Not Yet Recruiting
2026-08-18 NCT07771439 A Study to Investigate the Efficacy and Safety of Belumosudil Compared With Best… Phase 3 Not Yet Recruiting
2026-08-11 NCT07756957 Safety of the Acne mRNA Vaccine in Adolescents 12 to 17 Years of Age With Moderate to… Phase 2 Not Yet Recruiting

Active trials by phase

Phase 1
9
Phase 1/2
15
Phase 2
40
Phase 2/3
3
Phase 3
56
Phase 4
13
Not charted: 46 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 182

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07286214 Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica Polymyalgia Rheumatica Recruiting 2026-06-23
NCT07053423 A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants… Chronic Obstructive Pulmonary Disease Recruiting 2026-06-12
NCT06145373 A Study to Test a Medicine (Fitusiran) for Preventing Bleeds in People With Severe… Hemophilia A Recruiting 2026-06-02
NCT06666413 China Post-approval Commitment (PAC) Study of Avalglucosidase Alfa in Participants With… Glycogen Storage Disease Type II Recruiting 2026-03-23
NCT06671587 iGlarLixi CGM Study in Chinese T2D Individuals After OADs Type 2 Diabetes (T2D) Recruiting 2026-03-17
NCT06941870 Efanesoctocog Alfa Prophylaxis in Patients With Hemophilia A With Synovial Hypertrophy Factor VIII Deficiency Recruiting 2025-11-18
NCT07135973 A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above… Chronic Graft Versus Host Disease Not Yet Recruiting 2026-05-12
NCT05097287 Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline… Asthma Active, Not Recruiting 2026-04-16
NCT05983068 A Study of Long-term Effect of Dupilumab on Skin Barrier Function in Pediatric… Dermatitis Atopic Active, Not Recruiting 2026-04-13
NCT07109297 Study of Monoclonal Antibody Nirsevimab Against Respiratory Syncytial Virus (RSV) in… RSV Immunization Active, Not Recruiting 2026-03-23
NCT05757713 Teplizumab in Pediatric Stage 2 Type 1 Diabetes Diabetes Mellitus, Type 1 Active, Not Recruiting 2026-01-30
NCT06101095 A Study Assessing Esophageal Function and Remodeling With Dupilumab Compared With Placebo… Eosinophilic Oesophagitis Active, Not Recruiting 2025-12-23
NCT05164055 Avalglucosidase Alfa French Post-trial Access for Participants With Pompe Disease (PTA… Glycogen Storage Disease Type II Active, Not Recruiting 2025-10-31
Phase 3
NCT07190209 Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult… Chronic Obstructive Pulmonary Disease Recruiting 2026-09-02
NCT06290141 A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of… Chronic Inflammatory Demyelinating Polyneuropathy Recruiting 2026-08-26
NCT07086976 A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib… Autoimmune Haemolytic Anaemia Recruiting 2026-08-21
NCT07184996 An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants… Ulcerative Colitis Recruiting 2026-08-20
NCT07185009 A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants… Ulcerative Colitis Recruiting 2026-08-18
NCT07285460 A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male… Hemophilia Recruiting 2026-08-17
NCT07325292 Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous… Multiple Sclerosis Recruiting 2026-08-14
NCT07088068 A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in… Type 1 Diabetes Mellitus Recruiting 2026-08-10
NCT06975865 The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With… Sickle Cell Disease Recruiting 2026-07-29
NCT07190196 A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults… Immunoglobulin G4 Related Disease Recruiting 2026-07-28
NCT05263206 Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants… Pruritus Recruiting 2026-07-06
NCT07184931 An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants… Crohn's Disease Recruiting 2026-07-01
See all 182 active Sanofi / Regeneron trials with filters →

Disease areas by active trials, top 10 of 21

Diabetes (12) · COPD (9) · Type 1 Diabetes (9) · Multiple Myeloma (8) · Atopic Dermatitis (7) · Hemophilia (7) · Asthma (6) · Crohn's Disease (5) · Multiple Sclerosis (5) · Hidradenitis Suppurativa (3)

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