Sponsor Pipeline

National Heart, Lung, and Blood Institute (NHLBI) Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-07-19
82
Active Trials
57
Recruiting
1
Phase 3
10
Disease Areas
18
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-07-19 NCT03986034
Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic…
date change Primary completion pushed: 2026-07-03 -> 2026-11-17
2026-07-19 NCT03986034
Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic…
date change Completion pushed: 2026-07-03 -> 2026-11-17
2026-07-16 NCT04216342
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
date change Primary completion pushed: 2026-06-30 -> 2027-06-30
2026-07-16 NCT04216342
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
date change Completion pushed: 2026-06-30 -> 2027-06-30
2026-07-16 NCT03685721
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase…
date change Primary completion pushed: 2026-07-01 -> 2027-07-01
2026-07-16 NCT03685721
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase…
date change Completion pushed: 2026-07-01 -> 2027-07-01
2026-07-16 NCT02417714
Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)
date change Primary completion pushed: 2026-06-30 -> 2026-09-22
2026-07-16 NCT02417714
Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)
date change Completion pushed: 2026-07-01 -> 2026-09-22
2026-07-16 NCT05998408
JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure
Primary endpoint(s) modified
2026-07-15 NCT06093867
Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic…
date change Primary completion pushed: 2026-10-01 -> 2028-10-01
2026-07-15 NCT06093867
Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic…
date change Completion pushed: 2029-10-01 -> 2030-10-01
2026-07-15 NCT07613099
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation…
Recruitment opened
2026-07-07 NCT00071045
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and…
overall status: "Recruiting" → "Enrolling By Invitation"
2026-07-03 NCT05170399
Vaccine Responses in Patients With B Cell Malignancies
Enrollment reduced: 500 -> 350 participants
2026-06-26 NCT03312400
Low-Dose Danazol for the Treatment of Telomere Related Diseases
Trial completed
2026-06-26 NCT03312400
Low-Dose Danazol for the Treatment of Telomere Related Diseases
date change Primary completion moved earlier: 2027-04-29 -> 2025-10-31
2026-06-26 NCT03312400
Low-Dose Danazol for the Treatment of Telomere Related Diseases
date change Completion moved earlier: 2027-10-29 -> 2025-10-31
2026-06-23 NCT07566494
Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
overall status: "Enrolling By Invitation" → "Recruiting"
Active Trials by Phase
Phase 4
1
Phase 3
1
Phase 2
9
Phase 1/2
12
Phase 1
7
Early Phase 1
3
Not specified
49
Active Trials — top 25 of 82
NCT IDTitleConditionStatus
Phase 4
NCT05170399 Vaccine Responses in Patients With B Cell Malignancies Lymphoma Recruiting
Phase 3
NCT07613099 Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation… Allogeneic Stem Cell Transplantation Recruiting
Phase 2
NCT04304820 Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive… Severe Aplastic Anemia Recruiting
NCT03372733 Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults Cardiovascular Disease Recruiting
NCT06923072 Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological… Kohlmeier-Degos Disease Recruiting
NCT01174108 Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other… Severe Aplastic Anemia Recruiting
NCT03520647 Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH… Severe Aplastic Anemia (SAA) Recruiting
NCT03986034 Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic… Chronic Lymphocytic Leukemia Recruiting
NCT02979873 Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia… Severe Aplastic Anemia Active, Not Recruiting
NCT02514083 A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL Chronic Lymphocytic Leukemia Active, Not Recruiting
NCT01500733 PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Leukemia Active, Not Recruiting
Phase 1/2
NCT04008368 Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease… Myeloid Chimerism Recruiting
NCT01799538 Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis Lymphangioleiomyomatosis Recruiting
NCT03173937 Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and… Severe Aplastic Anemia Recruiting
NCT06032923 Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With… Systemic Lupus Erythematosus (Sle) Recruiting
NCT07599176 Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors Sickle Cell Disease Recruiting
NCT05357482 Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell… Sickle Cell Anemia Active, Not Recruiting
NCT01623167 Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia Severe Aplastic Anemia Active, Not Recruiting
NCT00977691 Haploidentical PBMC Transplant for Severe Congenital Anemias Sickle Cell Anemia Active, Not Recruiting
NCT03077542 Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell… Sickle Cell Disease Active, Not Recruiting
NCT06145282 Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease… Sickle Cell Disease Active, Not Recruiting
NCT04610866 Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat… Sickle Cell Disease Active, Not Recruiting
NCT05998408 JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure Severe Aplastic Anemia Active, Not Recruiting
Phase 1
NCT05967299 Study of Intravenous ZMA001 in Healthy Subjects Pulmonary Arterial Hypertension PAH Recruiting
NCT05904093 Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in… Sickle Cell Disease Recruiting
View all 82 active National Heart, Lung, and Blood Institute (NHLBI) trials with filters →
Disease Areas
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