Sponsor Pipeline

Merck (MSD) Clinical Trial Pipeline

Data updated daily from ClinicalTrials.gov — last refresh 2026-07-07
186
Active Trials
116
Recruiting
78
Phase 3
10
Disease Areas
100
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-07-07 NCT06818643
A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced…
Trial sites expanded: 45 -> 48 locations
2026-07-07 NCT07513376
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated…
Trial sites expanded: 10 -> 17 locations
2026-07-07 NCT03742895
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated…
Primary endpoint(s) modified
2026-07-07 NCT03742895
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated…
Trial arms changed: 1 -> 4
2026-07-07 NCT03742895
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated…
date change Completion pushed: 2026-06-30 -> 2027-06-30
2026-07-07 NCT06780137
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab…
Enrollment increased: 262 -> 327 participants
2026-07-07 NCT06780137
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab…
date change Primary completion moved earlier: 2029-08-31 -> 2029-04-27
2026-07-07 NCT06780137
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab…
date change Completion moved earlier: 2030-01-17 -> 2029-04-27
2026-07-07 NCT06637423
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer…
date change Primary completion pushed: 2026-06-30 -> 2029-03-14
2026-07-07 NCT06637423
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer…
date change Completion pushed: 2028-07-31 -> 2029-03-14
2026-07-07 NCT07190248
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With…
Trial sites expanded: 181 -> 186 locations
2026-07-07 NCT07489495
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell…
Trial sites expanded: 41 -> 47 locations
2026-07-07 NCT07318558
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer…
Trial sites expanded: 115 -> 118 locations
2026-07-03 NCT06966700
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast…
Trial sites expanded: 307 -> 310 locations
2026-07-03 NCT07661108
A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021)
Recruitment opened
2026-07-03 NCT07216703
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab…
Trial sites expanded: 135 -> 138 locations
2026-07-03 NCT07519772
A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008)
Trial sites expanded: 8 -> 13 locations
2026-07-03 NCT07058077
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and…
Trial sites expanded: 30 -> 33 locations
2026-07-03 NCT07634471
A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)
Trial sites expanded: 5 -> 8 locations
2026-07-02 NCT06721156
A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's…
Trial terminated
Showing 20 of 100 changes detected in the last 30 days.
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-30 NCT07677163 A Clinical Trial of MK-1403 in Healthy Participants (MK-1403-007) Phase 1 Not Yet Recruiting
2026-06-22 NCT07661108 A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021) Phase 1 Recruiting
2026-06-15 NCT07646860 A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial… Phase 2 Not Yet Recruiting
2026-06-08 NCT07634471 A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007) Phase 2/3 Recruiting
Active Trials by Phase
Phase 4
1
Phase 3
72
Phase 2/3
6
Phase 2
42
Phase 1/2
35
Phase 1
29
Not specified
1
Active Trials — top 25 of 186
NCT IDTitleConditionStatus
Phase 4
NCT07600723 A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in… Pulmonary Arterial Hypertension Not Yet Recruiting
Phase 3
NCT06351631 A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017) Thrombocythemia, Essential Recruiting
NCT06136624 Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) Prostate Cancer Metastatic Recruiting
NCT06655883 A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants… Insomnia Recruiting
NCT05947851 A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line… Leukemia, Lymphocytic, Chronic, B-Cell Recruiting
NCT06651281 Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With… Crohn Disease Recruiting
NCT06952504 A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab… Endometrial Cancer Recruiting
NCT06136650 A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA)… Metastatic Castration-resistant Prostate Cancer (mCRPC) Recruiting
NCT06345729 A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS… Non-small Cell Lung Cancer Recruiting
NCT06997497 A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People… Colon Adenocarcinoma Recruiting
NCT07405164 Extension Study for Participants in Studies That Include Belzutifan… Von Hippel-Lindau Disease Recruiting
NCT06136559 A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib… Chronic Lymphocytic Leukemia Recruiting
NCT06456346 Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007) Essential Thrombocythemia Recruiting
NCT07431827 MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC… Non-small Cell Lung Cancer Recruiting
NCT07554339 A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell… Non-small Cell Lung Cancer Recruiting
NCT06312137 A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab… Non Small Cell Lung Cancer Recruiting
NCT06312176 A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With… Breast Neoplasms Recruiting
NCT06393374 Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not… Triple-Negative Breast Cancer Recruiting
NCT06422143 Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in… Non-small Cell Lung Cancer Recruiting
NCT06430801 A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants… Crohn's Disease Recruiting
NCT06824467 A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870)… Ovarian Cancer Recruiting
NCT06841354 A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination… Triple Negative Breast Neoplasms Recruiting
NCT06925737 A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate… Prostate Cancer Recruiting
NCT07060807 A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016) Breast Neoplasms Recruiting
NCT07071623 A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010) Human Immunodeficiency Virus (HIV) Recruiting
View all 186 active Merck (MSD) trials with filters →
Disease Areas
Get alerts when Merck (MSD)'s trials change
Status changes, date slips, and new filings — detected daily, delivered to your inbox.
Start monitoring free