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Merck (MSD) clinical trial pipeline

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241 active trials 114 recruiting 105 Phase 3 10 disease areas 104 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 30 of 104 changes on 19 trials

2026-08-22
Reclassified as terminated (was completed)
Trial terminated: Trial was rendered as cancelled work ongoing in the book of business.
NCT04949256 Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus… · Phase 3
2026-08-13
Primary completion pushed: 2026-12-16 → 2027-03-31
Completion pushed: 2026-12-31 → 2027-04-15
NCT04665037 Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal… · Phase 2
2026-08-07
Primary completion pushed: 2026-06-30 → 2026-12-31
NCT06049212 Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in… · Phase 1
2026-08-21
Primary endpoint(s) modified
Trial sites expanded: 3 → 6 locations
NCT07225959 A Study of Annual Doses of MK-1406/CD388 in Healthy Adults (MK-1406-006/CD388.SQ.2.07) · Phase 2
2026-08-20
Primary endpoint(s) modified
Enrollment increased: 100 → 710 participants
NCT07300085 A Trial to Evaluate the Effect of CD388/MK1406 on the Immunogenicity of Fluzone® HD… · Phase 1
2026-08-08
Primary endpoint(s) modified
NCT06430801 A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants… · Phase 3
2026-08-15
Primary endpoint(s) modified
NCT03742895 Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated… · Phase 2
2026-08-08
Primary endpoint(s) modified
Enrollment increased: 200 → 280 participants
Trial sites expanded: 22 → 30 locations
NCT07519772 A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008) · Phase 1/2
2026-08-06
Primary endpoint(s) modified
Recruitment opened
Enrollment increased: 18 → 28 participants
NCT07697625 A Clinical Trial of MK-4082 in Healthy Participants (MK-4082-005) · Phase 1
2026-08-05
Enrollment reduced: 58 → 32 participants
Trial completed
Completion moved earlier: 2026-08-14 → 2026-07-15
NCT07219550 A Study of Calderasib (MK-1084) in Participants With Hepatic Impairment and Healthy… · Phase 1
2026-08-27
Recruitment opened
NCT07776665 A Clinical Trial of Enlicitide (MK-0616) Formulations in Healthy Participants… · Phase 1
2026-08-27
Trial completed
NCT07528508 A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527… · Phase 1
2026-08-26
Trial completed
NCT07532304 A Clinical Trial of MK-4646 With Bictegravir/Emtricitabine/Tenofovir Alafenamide and… · Phase 1
2026-08-20
Recruitment opened
NCT07646860 A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial… · Phase 2
2026-08-20
Recruitment opened
NCT07677163 A Clinical Trial of MK-1403 in Healthy Participants (MK-1403-007) · Phase 1
2026-08-18
Enrollment closed, study ongoing
NCT07242469 A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006) · Phase 1
2026-08-07
Enrollment closed, study ongoing
NCT07435194 A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels… · Phase 1
2026-08-06
Enrollment closed, study ongoing
NCT06442436 A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015) · Phase 1
2026-08-06
Enrollment closed, study ongoing
NCT07619443 A Clinical Study of MK-7262 and Enlicitide in Healthy Participants (MK-7262-003) · Phase 1
2026-08-04
Enrollment closed, study ongoing
NCT07528508 A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527… · Phase 1

New trial filings, last 30 days

First postedTrialPhaseStatus
2026-08-25 NCT07785609 A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With… Phase 2 Not Yet Recruiting
2026-08-25 NCT07785830 A Clinical Trial to Evaluate the Effects of MK-4646 on Rosuvastatin in Healthy… Phase 1 Not Yet Recruiting
2026-08-25 NCT07785843 A Clinical Study of V503 in Chinese Females Who Have Previously Received a Bivalent Human… Phase 3 Not Yet Recruiting
2026-08-20 NCT07776665 A Clinical Trial of Enlicitide (MK-0616) Formulations in Healthy Participants… Phase 1 Recruiting
2026-08-20 NCT07776691 A Study of Raludotatug Deruxtecan With or Without Bevacizumab as First-Line Maintenance… Phase 3 Not Yet Recruiting
2026-08-05 NCT07748351 A Clinical Trial of Multiple Formulations of MK-4082 in Healthy Overweight and Obese… Phase 1 Not Yet Recruiting
2026-08-03 NCT07743151 A Clinical Trial of MK-1406 in Healthy Participants (MK-1406-008) Phase 1 Not Yet Recruiting
2026-08-03 NCT07743164 A Clinical Trial of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab in… Phase 3 Not Yet Recruiting
2026-07-29 NCT07734610 A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027) Phase 1 Not Yet Recruiting

Active trials by phase

Phase 1
41
Phase 1/2
36
Phase 2
56
Phase 2/3
7
Phase 3
98
Phase 4
1
Not charted: 2 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 241

NCT IDTitleConditionStatusUpdated
Phase 4
NCT07600723 A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in… Pulmonary Arterial Hypertension Not Yet Recruiting 2026-08-07
Phase 3
NCT05947851 A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line… Leukemia, Lymphocytic, Chronic, B-Cell Recruiting 2026-08-27
NCT06136559 A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib… Chronic Lymphocytic Leukemia Recruiting 2026-08-27
NCT06170788 Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab… Non-small Cell Lung Cancer (NSCLC) Recruiting 2026-08-27
NCT06623422 A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in… Carcinoma, Non-Small-Cell Lung Recruiting 2026-08-27
NCT07513376 A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated… Non-small Cell Lung Cancer Recruiting 2026-08-26
NCT03486873 Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who… Solid Tumors Recruiting 2026-08-25
NCT06136624 Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) Prostate Cancer Metastatic Recruiting 2026-08-24
NCT06136650 A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA)… Metastatic Castration-resistant Prostate Cancer (mCRPC) Recruiting 2026-08-24
NCT06824467 A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870)… Ovarian Cancer Recruiting 2026-08-24
NCT06952504 A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab… Endometrial Cancer Recruiting 2026-08-24
NCT06966700 A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast… Breast Neoplasms Recruiting 2026-08-24
NCT07044297 A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1)… Human Immunodeficiency Virus (HIV) Recruiting 2026-08-24
NCT07060807 A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016) Breast Neoplasms Recruiting 2026-08-24
NCT07071623 A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010) Human Immunodeficiency Virus (HIV) Recruiting 2026-08-24
NCT07216703 A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab… Cervical Cancer Recruiting 2026-08-24
NCT07405164 Extension Study for Participants in Studies That Include Belzutifan… Von Hippel-Lindau Disease Recruiting 2026-08-24
NCT07419295 A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer… Bladder Cancer Recruiting 2026-08-24
NCT07489495 A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell… Carcinoma, Renal Cell Recruiting 2026-08-24
NCT06077760 A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus… Non-small Cell Lung Cancer Recruiting 2026-08-21
NCT06312137 A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab… Non Small Cell Lung Cancer Recruiting 2026-08-21
NCT06393374 Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not… Triple-Negative Breast Cancer Recruiting 2026-08-21
NCT06430801 A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants… Crohn's Disease Recruiting 2026-08-21
NCT06717347 A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus… Diffuse Large B-Cell Lymphoma Recruiting 2026-08-21
NCT06841354 A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination… Triple Negative Breast Neoplasms Recruiting 2026-08-21
See all 241 active Merck (MSD) trials with filters →

Disease areas by active trials

Lung Cancer (31) · Non-Small Cell Lung Cancer (NSCLC) (27) · Bladder Cancer (13) · Kidney Cancer (10) · Breast Cancer (10) · Leukemia (8) · Hypertension (7) · Melanoma (6) · Small Cell Lung Cancer (6) · Chronic Lymphocytic Leukemia (CLL) (6)

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