Disease landscape

DLBCL clinical trials

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548 active trials 301 recruiting 48 Phase 3 286 sponsors 54 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-09-05

What changed in the last 30 days showing 34 of 54 changes on 20 trials

2026-08-26
Primary completion pushed: 2026-07 → 2026-11
Enrollment reduced: 39 → 21 participants
Completion pushed: 2026-07 → 2026-11
NCT06079164 Study of KITE-197 in Participants With Relapsed or Refractory Large B-cell Lymphoma · Kite, A Gilead Company · Phase 1
2026-08-29
Primary completion pushed: 2027-09-01 → 2028-09-01
Completion pushed: 2027-09-01 → 2028-09-01
NCT06649812 Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With… · National Cancer Institute (NCI) · Phase 2
2026-08-14
Primary completion pushed: 2027-11-24 → 2028-04-21
NCT06526793 Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R)… · AstraZeneca · Phase 2
2026-08-29
Primary completion pushed: 2027-07-31 → 2028-07-31
Completion pushed: 2029-07-31 → 2030-07-31
NCT06687772 CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based… · Washington University School of Medicine · Phase 2
2026-08-28
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2026-07 → 2027-07
NCT04464200 19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers · Memorial Sloan Kettering Cancer Center · Phase 1
2026-08-08
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2028-06-30 → 2029-06-30
NCT06486051 A Study of Atlacabtagene Autoleucel CAR T-cells for Adults With Relapsed Large B-cell… · Malaghan Institute of Medical Research · Phase 2
2026-08-22
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2027-05 → 2028-05
NCT06227026 Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the… · University of Utah · Phase 1
2026-08-21
Primary completion pushed: 2026-08-01 → 2027-08-01
Completion pushed: 2027-08-01 → 2028-08-01
NCT04007029 Modified Immune Cells (CD19/CD20 CAR-T Cells) in Treating Patients With Recurrent or… · Jonsson Comprehensive Cancer Center · Phase 1
2026-08-07
Primary completion pushed: 2026-07 → 2028-07
Completion pushed: 2027-07 → 2030-07
NCT05990465 LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell… · Medical College of Wisconsin · Phase 1
2026-08-22
Primary endpoint(s) modified
NCT05006716 A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With… · BeOne Medicines · Phase 1/2
2026-08-14
Primary endpoint(s) modified
Enrollment increased: 30 → 40 participants
Trial arms changed: 1 → 2
NCT06811272 Outpatient Epcoritamab in Large B-cell Lymphoma · Massachusetts General Hospital · Phase 2
2026-09-05
Enrollment closed, study ongoing
NCT04609046 Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS… · National Cancer Institute (NCI) · Phase 1
2026-08-29
Enrollment closed, study ongoing
Final enrollment: 39 participants (planned 154)
NCT05512390 A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously… · AbbVie · Phase 1
2026-08-14
Recruitment opened
NCT07570823 A Study to Evaluate the Safety and Efficacy of SCTB35 in Combination With Gemcitabine and… · Sinocelltech Ltd. · Phase 3
2026-08-20
Sponsor changed: Mwanasha Merrill, MD → Carrie Ho, MD
Primary completion pushed: 2028-07-31 → 2028-08-31
Completion pushed: 2029-07-31 → 2029-08-31
NCT07588698 Epcoritamab in Combination With R-CHOP for Patients With Aggressive Non-Hodgkin Lymphoma · Carrie Ho, MD · Phase 2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07078500 Orelabrutinib Combined With Pola-R-CHP Regimen for the Treatment of Untreated Non-GCB… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06554600 A Study of Zanubrutinib in Combination With Polatuzumab Vedotin, Bendamustine and… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT06464861 Sequential Treatment of CD19 CARNK and 7x19 CAR-T in R/R B Cell Lymphoma · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 1
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07669194 Glofitamab Combined With Selinexor in Patients With Relapsed/Refractory Diffuse Large… · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-26
Recruitment opened
NCT06594939 Mosunetuzumab and Polatuzumab Vedotin With Split-Dose CHP Chemotherapy for Elderly… · Medical College of Wisconsin · Phase 2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-26 NCT07788118 A Phase Ib/II Exploratory Clinical Trial of Memory-Enhanced 7×19-THEMIS CAR-T Cell… Second Affiliated Hospital, Zhejiang University, School of Medicine new Phase 1/2
2026-08-24 NCT07782944 CD38 Targeted -PET/ CT for Multiple Myeloma Guilin Medical University, China new
2026-08-18 NCT07771361 BAFF CAR-T Cells (LMY-920) for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma… Luminary Therapeutics new Phase 2
2026-08-14 NCT07764601 R-MA-PD-1 Versus R-MA in Treatment-naive Primary CNS Lymphoma WEI XU new
2026-08-06 NCT07749976 GRACE: A Phase 1/2a Study of VTRU200 in Relapsed/Refractory AML, High-risk MDS, DLBCL… Vitruviae new Phase 1/2
2026-08-06 NCT07750886 Sample Collection for Ongoing Research and Product Evaluation Study - Non-Hodgkin… Natera, Inc. new
2026-08-05 NCT07748364 Glofitamab in B-NHL Using Mid-Therapy Intratumoral Transcriptomics Joshua Brody new Phase 2
2026-07-31 NCT07739654 Modified DHAP Versus Standard DHAP in Relapsed/Refractory Diffused Large B-cell Lymphoma. King Edward Medical University new Phase 3
2026-07-27 NCT07729397 Autologous IC-Nine, CD30 CAR, and Constitutive IL7R Expressing EBVST for CD30 Lymphoma… The Methodist Hospital Research Institute new Phase 1
2026-07-24 NCT07725406 Low-Dose TBI Plus CAR T-Cell Therapy for Relapsed/Refractory DLBCL and Multiple Myeloma Weill Medical College of Cornell University new Phase 1

Active trials by phase

Early Phase 1
10
Phase 1
104
Phase 1/2
79
Phase 2
199
Phase 2/3
9
Phase 3
39
Phase 4
2
Not charted: 106 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 548

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05518383 B-cell Mature Non-Hodgkin's Lymphoma Treatment Protocol in Children and Adolescents 2021 Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting 2022-08-26
NCT07760610 Pomalidomide Plus Rituximab Maintenance in Young High-Risk Newly Diagnosed DLBCL After… The First Hospital of Jilin University Not Yet Recruiting 2026-08-12
Phase 3
NCT07479797 Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants… Kite, A Gilead Company Recruiting 2026-09-04
NCT06717347 A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus… Merck Sharp & Dohme LLC Recruiting 2026-09-03
NCT06091865 A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it… Regeneron Pharmaceuticals Recruiting 2026-08-20
NCT06792253 Study Comparing BEBT-908 Combined With R to SOC for the Treatment of Relapsed/Refractory… BeBetter Med Inc Recruiting 2026-08-19
NCT07570823 A Study to Evaluate the Safety and Efficacy of SCTB35 in Combination With Gemcitabine and… Sinocelltech Ltd. Recruiting 2026-08-13
NCT07739654 Modified DHAP Versus Standard DHAP in Relapsed/Refractory Diffused Large B-cell Lymphoma. King Edward Medical University Recruiting 2026-08-10
NCT07188558 A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy Lyell Immunopharma, Inc. Recruiting 2026-08-04
NCT01804686 A Long-term Extension Study of PCI-32765 (Ibrutinib) Janssen Research & Development, LLC Recruiting 2026-07-31
NCT07409428 A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory… Hutchmed Recruiting 2026-07-20
NCT06929624 A Phase 3 Clinical Study of SHR-A1912 Combined With R-GemOx Versus R-GemOx in Diffuse… Suzhou Suncadia Biopharmaceuticals Co., Ltd. Recruiting 2026-07-01
NCT05820841 Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large… Universität des Saarlandes Recruiting 2026-06-29
NCT04094311 Study of Out of Specification for Tisagenlecleucel Novartis Pharmaceuticals Recruiting 2026-06-25
NCT07215585 AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL AstraZeneca Recruiting 2026-06-18
NCT05018520 The Safety and Effectiveness of 4R-CHOP+4R vs 6R-CHOP+2R in Newly Diagnosed Patients With… Ruijin Hospital Recruiting 2026-05-11
NCT07493109 Chidamide for Maintenance Treatment of HBV-infected Diffuse DLBCL in Patients Initially… Ou Bai, MD/PHD Recruiting 2026-03-25
NCT06220032 Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With… Stichting Hemato-Oncologie voor Volwassenen Nederland Recruiting 2026-01-05
NCT07011056 A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse… Chengdu Zenitar Biomedical Technology Co., Ltd Recruiting 2025-09-19
NCT04332822 A Randomized, Multicenter, Phase III Trial Comparing Treatment With R-mini-CHOP With… Nordic Lymphoma Group Recruiting 2024-09-19
NCT06522555 The Efficacy and Safety of Pola-ZR2 Versus ZR2 in the Treatment of Old Patients With de… Ruijin Hospital Recruiting 2024-08-05
NCT06521255 Evaluate the Safety and Efficacy of Tafasitamab and Lenalidomide in Combination With… Beijing InnoCare Pharma Tech Co., Ltd. Recruiting 2024-07-25
NCT04442412 Prephase Treatment With Prednisone +/- Vitamin D Supplementation Followed by… Fondazione Italiana Linfomi - ETS Recruiting 2022-08-26
NCT04670029 Impact of an APA Program on EFS in Patients With Diffuse Large-cell B Lymphoma Treated in… Weprom Recruiting 2021-10-08
NCT04759586 Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed… National Cancer Institute (NCI) Active, Not Recruiting 2026-08-24
See all 548 active DLBCL trials with filters →

Top sponsors by active trials in this area

Ruijin Hospital (33) · National Cancer Institute (NCI) (20) · City of Hope Medical Center (14) · Sun Yat-sen University (11) · Memorial Sloan Kettering Cancer Center (10) · The First Affiliated Hospital with Nanjing Medical University (9) · Genmab (8) · M.D. Anderson Cancer Center (8) · Fondazione Italiana Linfomi - ETS (7) · Institute of Hematology & Blood Diseases Hospital, China (7)

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