| Detected | Trial | Change |
|---|---|---|
| 2026-08-14 | NCT06712316 Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… |
Primary endpoint(s) modified |
| 2026-08-14 | NCT06712316 Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… |
Enrollment increased: 1260 -> 1580 participants |
| 2026-08-14 | NCT06712316 Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… |
Trial arms changed: 8 -> 10 |
| 2026-08-14 | NCT06712316 Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… |
date change Primary completion moved earlier: 2029-02 -> 2029-01 |
| 2026-08-14 | NCT06712316 Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… |
date change Completion pushed: 2030-03 -> 2031-12 |
| 2026-08-08 | NCT07222384 A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5… |
Trial completed |
| 2026-08-08 | NCT07730450 A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age |
Recruitment opened |
| 2026-08-07 | NCT05543616 A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy… |
Trial completed |
| 2026-08-06 | NCT07111520 A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… |
Enrollment increased: 420 -> 880 participants |
| 2026-08-06 | NCT07111520 A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… |
Trial arms changed: 15 -> 25 |
| 2026-08-06 | NCT07111520 A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… |
Trial sites expanded: 68 -> 85 locations |
| 2026-08-06 | NCT07111520 A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… |
date change Primary completion moved earlier: 2029-01 -> 2028-11 |
| 2026-08-06 | NCT07111520 A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… |
date change Completion pushed: 2030-01 -> 2030-06 |
| 2026-08-04 | NCT07173751 ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative… |
Trial sites expanded: 155 -> 161 locations |
| 2026-07-29 | NCT07255404 A Clinical Trial Testing the Safety of Pumitamig (an Investigational Drug) and How Well… |
Trial sites expanded: 10 -> 24 locations |
| 2026-07-25 | NCT06712355 Safety and Efficacy of BNT327, an Investigational Therapy in Combination With… |
Trial sites expanded: 211 -> 221 locations |
| 2026-07-23 | NCT07070232 A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… |
Enrollment increased: 980 -> 1438 participants |
| 2026-07-23 | NCT07070232 A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… |
Trial arms changed: 16 -> 18 |
| 2026-07-23 | NCT07070232 A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… |
Trial sites expanded: 64 -> 67 locations |
| 2026-07-23 | NCT07070232 A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… |
date change Completion pushed: 2029-10 -> 2030-03 |
| First Posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-07-28 | NCT07730450 A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age | Phase 4 | Recruiting |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 4 | |||
| NCT07730450 | A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age | COVID-19 Vaccines | Recruiting |
| Phase 3 | |||
| NCT07365995 | A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate… | Metastatic Castration-resistant Prostate Cancer | Recruiting |
| NCT06340568 | A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy… | Endometrial Cancer | Recruiting |
| NCT06712355 | Safety and Efficacy of BNT327, an Investigational Therapy in Combination With… | Extensive-stage Small-cell Lung Cancer | Recruiting |
| NCT07173751 | ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative… | Breast Neoplasms | Recruiting |
| NCT07300839 | A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age | COVID-19 | Active, Not Recruiting |
| Phase 2/3 | |||
| NCT04534205 | A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of… | Unresectable Head and Neck Squamous Cell Carcinoma | Recruiting |
| NCT06712316 | Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… | Non-small Cell Lung Cancer | Recruiting |
| Phase 2 | |||
| NCT06841055 | Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for… | Non-small Cell Lung Cancer | Recruiting |
| NCT07297212 | A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and… | Recurrent Glioblastoma | Recruiting |
| NCT07255404 | A Clinical Trial Testing the Safety of Pumitamig (an Investigational Drug) and How Well… | Pancreatic Ductal Adenocarcinoma (PDAC) | Recruiting |
| NCT07379580 | A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity… | Mpox (Monkeypox) | Recruiting |
| NCT06449209 | Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With… | Extensive-stage Small-cell Lung Cancer | Active, Not Recruiting |
| NCT06449222 | Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast… | Locally Advanced Breast Cancer | Active, Not Recruiting |
| NCT04486378 | A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in… | Colorectal Cancer Stage II | Active, Not Recruiting |
| Phase 1/2 | |||
| NCT07147348 | A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as… | Advanced Solid Tumor | Recruiting |
| NCT07079631 | A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in… | Metastatic Colorectal Cancer | Recruiting |
| NCT06892548 | A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination… | Advanced Lung Cancer | Recruiting |
| NCT07186842 | A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially… | Advanced Solid Cancers | Recruiting |
| NCT06827236 | A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323… | Locally Advanced Breast Cancer | Recruiting |
| NCT07070232 | A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… | Advanced Solid Tumor | Recruiting |
| NCT07111520 | A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… | Non-small Cell Lung Cancer | Recruiting |
| NCT07455734 | Early-phase Trial to Assess the Safety and Preliminary Efficacy of BNT3214 in Adults With… | Advanced Solid Tumor Cancer | Recruiting |
| NCT05547464 | Safety and Immune Responses After Vaccination With Two Investigational RNA-based Vaccines… | Tuberculosis | Active, Not Recruiting |
| Phase 1 | |||
| NCT06750185 | Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced… | Advanced Solid Tumor | Recruiting |