Notable
COVID-19 Vaccine(s) in Children and Adults
Recruitment opened
Also in this update: Trial sites expanded: 0 → 14 locations
BioNTech SEPhase 3 NCT07798648 Registry history of NCT07798648 on ClinicalTrials.gov (opens the registry)
Updated
31 active trials 23 recruiting 8 Phase 3 11 disease areas 13 changes in 30 days
10 trials changed in the last 30 days: 0 stopped, 2 with notable changes, 8 with minor changes only.
Recruitment opened
Also in this update: Trial sites expanded: 0 → 14 locations
BioNTech SEPhase 3 NCT07798648 Registry history of NCT07798648 on ClinicalTrials.gov (opens the registry)
Updated
Results posted: Sep 15, 2026
BioNTech SEPhase 1/2 NCT05988203 Registry history of NCT05988203 on ClinicalTrials.gov (opens the registry)
Updated
Trial sites expanded: 202 → 212 locations
And 1 more change in the last 30 days
BioNTech SEPhase 3 NCT07173751 Registry history of NCT07173751 on ClinicalTrials.gov (opens the registry)
Updated
Trial sites expanded: 262 → 365 locations
BioNTech SEPhase 2/3 NCT06712316 Registry history of NCT06712316 on ClinicalTrials.gov (opens the registry)
Updated
Trial sites reduced: 145 → 142 locations
BioNTech SEPhase 2/3 NCT04534205 Registry history of NCT04534205 on ClinicalTrials.gov (opens the registry)
Updated
Trial sites expanded: 30 → 33 locations
BioNTech SEPhase 3 NCT07365995 Registry history of NCT07365995 on ClinicalTrials.gov (opens the registry)
Updated
Trial sites expanded: 181 → 191 locations
BioNTech SEPhase 3 NCT06340568 Registry history of NCT06340568 on ClinicalTrials.gov (opens the registry)
Updated
Completion moved earlier from Aug 2030 to Nov 2026
BioNTech SEPhase 2 NCT04486378 Registry history of NCT04486378 on ClinicalTrials.gov (opens the registry)
Updated
Completion moved earlier from May 2028 to Feb 2028
BioNTech SEPhase 2 NCT06449209 Registry history of NCT06449209 on ClinicalTrials.gov (opens the registry)
Updated
Primary completion date changed from estimate of Jun 2027 to Aug 18, 2026
Also in this update: Completion moved earlier from Mar 2028 to Nov 2026
BioNTech SEPhase 1 NCT06150183 Registry history of NCT06150183 on ClinicalTrials.gov (opens the registry)
Updated
| Phase 1 | 5 | |
| Phase 1/2 | 10 | |
| Phase 2 | 7 | |
| Phase 2/3 | 2 | |
| Phase 3 | 6 | |
| Phase 4 | 1 |
| NCT ID | Title | Condition | Status | Updated |
|---|---|---|---|---|
| Phase 4 | ||||
| NCT07730450 | A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age | COVID-19 Vaccines | Recruiting | 2026-08-07 |
| Phase 3 | ||||
| NCT07173751 | ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative… | Breast Neoplasms | Recruiting | 2026-10-06 |
| NCT07798648 | A Study of COVID-19 Vaccine(s) in Children and Adults | COVID-19 Vaccines | Recruiting | 2026-09-28 |
| NCT07365995 | A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate… | Metastatic Castration-resistant Prostate Cancer | Recruiting | 2026-09-18 |
| NCT06340568 | A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy… | Endometrial Cancer | Recruiting | 2026-09-17 |
| NCT06712355 | Safety and Efficacy of BNT327, an Investigational Therapy in Combination With… | Extensive-stage Small-cell Lung Cancer | Recruiting | 2026-09-01 |
| NCT07300839 | A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age | COVID-19 | Active, Not Recruiting | 2026-04-13 |
| Phase 2/3 | ||||
| NCT06712316 | Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and… | Non-small Cell Lung Cancer | Recruiting | 2026-09-22 |
| NCT04534205 | A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of… | Unresectable Head and Neck Squamous Cell Carcinoma | Active, Not Recruiting | 2026-09-21 |
| Phase 2 | ||||
| NCT07379580 | A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity… | Mpox (Monkeypox) | Recruiting | 2026-08-11 |
| NCT07255404 | A Clinical Trial Testing the Safety of Pumitamig (an Investigational Drug) and How Well… | Pancreatic Ductal Adenocarcinoma (PDAC) | Recruiting | 2026-07-28 |
| NCT07297212 | A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and… | Recurrent Glioblastoma | Recruiting | 2026-04-29 |
| NCT06841055 | Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for… | Non-small Cell Lung Cancer | Recruiting | 2026-04-24 |
| NCT04486378 | A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in… | Colorectal Cancer Stage II | Active, Not Recruiting | 2026-10-07 |
| NCT06449209 | Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With… | Extensive-stage Small-cell Lung Cancer | Active, Not Recruiting | 2026-09-14 |
| NCT06449222 | Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast… | Locally Advanced Breast Cancer | Active, Not Recruiting | 2026-06-30 |
| Phase 1/2 | ||||
| NCT07070232 | A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and… | Advanced Solid Tumor | Recruiting | 2026-10-09 |
| NCT06827236 | A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323… | Locally Advanced Breast Cancer | Recruiting | 2026-09-17 |
| NCT06750185 | Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced… | Advanced Solid Tumor | Recruiting | 2026-09-09 |
| NCT07186842 | A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially… | Advanced Solid Cancers | Recruiting | 2026-08-27 |
| NCT06892548 | A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination… | Advanced Lung Cancer | Recruiting | 2026-08-26 |
| NCT07455734 | Early-phase Trial to Assess the Safety and Preliminary Efficacy of BNT3214 in Adults With… | Advanced Solid Tumor Cancer | Recruiting | 2026-08-13 |
| NCT07111520 | A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327… | Non-small Cell Lung Cancer | Recruiting | 2026-08-05 |
| NCT07079631 | A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in… | Metastatic Colorectal Cancer | Recruiting | 2026-07-01 |
| NCT07147348 | A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as… | Advanced Solid Tumor | Recruiting | 2026-06-15 |
Lung Cancer (7) · Non-Small Cell Lung Cancer (NSCLC) (4) · Breast Cancer (3) · Colorectal Cancer (2) · Small Cell Lung Cancer (2) · Endometrial Cancer (1) · Glioblastoma (1) · Head & Neck Cancer (1) · Pancreatic Cancer (1) · Prostate Cancer (1)