Notable
ARO-DIMERPA · Mixed Hyperlipidemia
Primary completion pushed from Sep 30, 2026 to Jul 2027
Arrowhead PharmaceuticalsPhase 1/2 NCT07223658 Registry history of NCT07223658 on ClinicalTrials.gov (opens the registry)
Updated
8 trials changed in the last 30 days: 0 stopped, 2 with notable changes, 6 with minor changes only.
Primary completion pushed from Sep 30, 2026 to Jul 2027
Arrowhead PharmaceuticalsPhase 1/2 NCT07223658 Registry history of NCT07223658 on ClinicalTrials.gov (opens the registry)
Updated
Recruitment opened
And 1 more change in the last 30 days
Arrowhead PharmaceuticalsPhase 3 NCT07473843 Registry history of NCT07473843 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Arrowhead PharmaceuticalsPhase 3 NCT06347016 Registry history of NCT06347016 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Arrowhead PharmaceuticalsPhase 3 NCT06347003 Registry history of NCT06347003 on ClinicalTrials.gov (opens the registry)
Updated
Enrollment closed, study ongoing
Also in this update: Final enrollment: 710 participants (planned 869)
Arrowhead PharmaceuticalsPhase 3 NCT06822790 Registry history of NCT06822790 on ClinicalTrials.gov (opens the registry)
Updated
Trial completed
Arrowhead PharmaceuticalsPhase 3 NCT06347133 Registry history of NCT06347133 on ClinicalTrials.gov (opens the registry)
Updated
Trial sites expanded: 121 → 140 locations
Arrowhead PharmaceuticalsPhase 3 NCT06880770 Registry history of NCT06880770 on ClinicalTrials.gov (opens the registry)
Updated
Trial sites expanded: 7 → 15 locations
Arrowhead PharmaceuticalsPhase 1/2 NCT06700538 Registry history of NCT06700538 on ClinicalTrials.gov (opens the registry)
Updated
| First posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-10-06 | NCT07859813 A Trial to Evaluate the Efficacy and Safety of ARO-INHBE in Adults With Metabolic… | Phase 2 | Not Yet Recruiting |
| Phase 1 | 2 | |
| Phase 1/2 | 4 | |
| Phase 2 | 2 | |
| Phase 3 | 4 |
| NCT ID | Title | Condition | Status | Updated |
|---|---|---|---|---|
| Phase 3 | ||||
| NCT07473843 | Study of Zodasiran in Adolescent Participants With Homozygous Familial… | Homozygous Familial Hypercholesterolemia | Recruiting | 2026-10-06 |
| NCT06880770 | Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute… | Severe Hypertriglyceridemia | Recruiting | 2026-09-21 |
| NCT06822790 | Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia | Hypertriglyceridemia | Active, Not Recruiting | 2026-10-01 |
| NCT07037771 | A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial… | Homozygous Familial Hypercholesterolemia | Active, Not Recruiting | 2026-08-12 |
| Phase 2 | ||||
| NCT07241546 | Study of Inhaled ARO-RAGE in Allergen-induced Mild Asthma | Asthma | Recruiting | 2026-10-01 |
| NCT07859813 | A Trial to Evaluate the Efficacy and Safety of ARO-INHBE in Adults With Metabolic… | Metabolic Dysfunction-Associated Steatohepatitis | Not Yet Recruiting | 2026-10-06 |
| Phase 1/2 | ||||
| NCT07223658 | Study of ARO-DIMERPA in Adult Participants With Mixed Hyperlipidemia | Hyperlipidemia; Mixed | Recruiting | 2026-10-13 |
| NCT06700538 | A First-In-Human Study of ARO-INHBE in Adults With Obesity With and Without Type 2… | Obesity | Recruiting | 2026-09-25 |
| NCT07221344 | Study of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's… | Alzheimer Disease | Recruiting | 2026-09-18 |
| NCT06937203 | A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2… | Obesity | Recruiting | 2026-07-08 |
| Phase 1 | ||||
| NCT07662096 | A First-In-Human Study of ARO-033 in Adult Participants | Age-related Macular Degeneration | Recruiting | 2026-09-15 |
| NCT06672445 | Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2 | Spinocerebellar Ataxia Type 2 | Active, Not Recruiting | 2026-06-29 |
Obesity (2) · Alzheimer's Disease (1) · Asthma (1) · Dementia (1) · Diabetes (1) · NASH / MASH (1) · Type 2 Diabetes (1)