| Detected | Trial | Change |
|---|---|---|
| 2026-08-02 | NCT06166472 A Study to Evaluate the Safety, Tolerance, Pharmacokinetics, and Preliminary… |
overall status: Not Yet Recruiting → Unknown |
| 2026-07-30 | NCT07623356 A Study of AK138D1 Alone or in Combination With Ivonescimab in Advanced Non-Small Cell… |
Recruitment opened |
| 2026-07-30 | NCT05247684 AK112 Neoadjuvant/Adjuvant Treatment for Resectable NSCLC |
Primary endpoint(s) modified |
| 2026-07-30 | NCT05247684 AK112 Neoadjuvant/Adjuvant Treatment for Resectable NSCLC |
date change Completion pushed: 2026-12-31 -> 2027-12-31 |
| 2026-07-23 | NCT07591090 A Phase II Study of AK146D1 Combined With AK112 in Advanced Breast Cancer |
Recruitment opened |
| First Posted | Trial | Phase | Status |
|---|---|---|---|
| 2026-08-10 | NCT07755371 A Study to Evaluate the Efficacy and Safety of AK139 in Participants With Chronic… | Phase 2 | Not Yet Recruiting |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 3 | |||
| NCT06341335 | A Study of AK104/Placebo Plus AK109/Placebo And Paclitaxel in Gastric or Gastroesophageal… | Gastric and Gastroesophageal Junction Adenocarcinoma | Recruiting |
| NCT06601335 | A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head… | Head and Neck Squamous Cell Carcinoma | Recruiting |
| NCT05489289 | A Phase III Study of AK104 as Adjuvant Therapy in HCC With High Risk of Recurrence After… | Hepatocellular Carcinoma | Recruiting |
| NCT06371157 | A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE)… | Hepatocellular Carcinoma | Recruiting |
| NCT06617416 | A Study of AK104 in Subjects With Unresectable Locally Advanced NSCLC | NSCLC (Non-small Cell Lung Cancer) | Recruiting |
| NCT07023315 | A Phase III Clinical Study of Cadonilimab Plus SOX as Perioperative Treatment for… | Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma | Recruiting |
| NCT06951503 | AK112 and Chemotherapy in First-line Metastatic Colorectal Cancer | Colorectal Adenocarcinoma | Recruiting |
| NCT06953999 | A Phase III Study of Ivonescimab + Chemo With/Without AK117 in Metastatic Pancreatic… | Pancreatic Cancer | Recruiting |
| NCT07010263 | A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell… | Small Cell Lung Cancer | Recruiting |
| NCT06767527 | AK112 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally… | Triple-Negative Breast Cancer (TNBC) | Recruiting |
| NCT06928389 | Ivonescimab in Combination With Docetaxel in Advanced Non-Small Cell Lung Cancer | Non-Small Cell Lung Cancer | Recruiting |
| NCT07412613 | Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch… | Resectable Colon Cancer | Recruiting |
| NCT05990127 | A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1%… | Locally Advanced or Metastatic NSCLC | Not Yet Recruiting |
| NCT05235516 | A Study of AK104/Placebo Combined With Chemoradiotherapy For The Treatment of Locally… | Locally Advanced Cervical Carcinoma | Active, Not Recruiting |
| NCT06767540 | A Clinical Study of AK120 in Adolescents With Moderate-to-severe Atopic Dermatitis | Atopic Dermatitis | Not Yet Recruiting |
| NCT04974398 | A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic… | Nasopharyngeal Carcinoma | Active, Not Recruiting |
| NCT05840016 | AK112 in Combination With Chemotherapy in Advanced Squamous Non-Small Cell Lung Cancer | Advanced Squamous Non Small Cell Lung Cancer | Active, Not Recruiting |
| NCT04982237 | A Study of AK104 Plus Platinum-containing Chemotherapy±Bevacizumab as First-line… | Cervical Cancer | Active, Not Recruiting |
| NCT06591520 | AK112 Combined With Chemotherapy Versus Durvalumab Combined With Chemotherapy in Advanced… | Biliary Tract Cancer | Active, Not Recruiting |
| NCT05184712 | Phase 3 Clinical Study of AK112 for NSCLC Patients | Non-Squamous Non-small Cell Lung Cancer | Active, Not Recruiting |
| NCT07449780 | A Study of AK104 (SC) in Combination With Oxaliplatin and Capecitabine (XELOX) Versus… | Gastric / Gastroesophageal Junction Adenocarcinoma | Not Yet Recruiting |
| NCT05499390 | AK112 in Advanced Non-Small Cell Lung Cancer | Advanced Non-small-cell Lung Cancer | Active, Not Recruiting |
| NCT07700979 | Phase 3 Study of Cadonilimab Combined With Chemotherapy vs Chemotherapy in Combination… | Gastric / Gastroesophageal Junction Adenocarcinoma | Not Yet Recruiting |
| Phase 2 | |||
| NCT05960955 | Cadonilimab Combination With Chemotherapy With or Without AK117 in Resectable Gastric or… | Resectable Gastric or Gastroesophageal Junction Adenocarcinoma | Recruiting |
| NCT05859750 | A Study of AK104 With Chemotherapy as First-line Treatment in Patients With Advanced… | Pancreatic Cancer | Recruiting |