Drug Pipeline

Luspatercept Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-06-12
44
Active Studies
23
Recruiting
11
Phase 3
10
Top Sponsors
20
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-06-09 NCT06113302
A Pilot, Open-Label Study of Luspatercept for Patients With Lower Risk Myelodysplastic…
overall status: "Recruiting" → "Active Not Recruiting"
2026-06-09 NCT06113302
A Pilot, Open-Label Study of Luspatercept for Patients With Lower Risk Myelodysplastic…
Enrollment reduced: 40 -> 10 participants
2026-06-05 NCT07523009
CsA+EPAG/HPAG+Romiplostim N01 in the Treatment of Newly-diagnosed SAA/TD-NSAA
overall status: "Not Yet Recruiting" → "Withdrawn"
2026-06-05 NCT07523009
CsA+EPAG/HPAG+Romiplostim N01 in the Treatment of Newly-diagnosed SAA/TD-NSAA
critical why stopped: null → "The registration of this research plan was incorrect. A new registration has been re-applied for."
2026-06-05 NCT07523009
CsA+EPAG/HPAG+Romiplostim N01 in the Treatment of Newly-diagnosed SAA/TD-NSAA
Enrollment reduced: 43 -> 0 participants
2026-06-05 NCT07522996
Enarodustat+CsA vs CsA in the Treatment of Newly-diagnosed TD-NSAA
overall status: "Not Yet Recruiting" → "Withdrawn"
2026-06-05 NCT07522996
Enarodustat+CsA vs CsA in the Treatment of Newly-diagnosed TD-NSAA
critical why stopped: null → "The registration of this research plan was incorrect. A new registration has been re-applied for."
2026-06-05 NCT07522996
Enarodustat+CsA vs CsA in the Treatment of Newly-diagnosed TD-NSAA
Enrollment reduced: 90 -> 0 participants
2026-05-24 NCT07463950
A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical…
date change Primary completion pushed: 2026-05-04 -> 2026-06-09
2026-05-24 NCT07463950
A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical…
date change Completion pushed: 2026-05-04 -> 2026-06-09
2026-05-23 NCT06752694
Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell…
overall status: "Recruiting" → "Active Not Recruiting"
2026-05-23 NCT06752694
Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell…
Enrollment reduced: 20 -> 1 participants
2026-05-23 NCT06752694
Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell…
date change Primary completion moved earlier: 2027-12-31 -> 2026-01-23
2026-05-23 NCT06752694
Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell…
date change Completion moved earlier: 2027-12-31 -> 2026-10-15
2026-05-21 NCT01962636
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for…
Trial terminated — check why_stopped for reason
2026-05-21 NCT01962636
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for…
critical why stopped: null → "No longer a research question to answer."
2026-05-21 NCT01962636
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for…
date change Primary completion moved earlier: 2027-02 -> 2026-05-14
2026-05-21 NCT01962636
Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for…
date change Completion moved earlier: 2028-02 -> 2026-05-14
2026-05-15 NCT07566377
Cord Blood Transplantation in Children and Young Adults With Blood Cancer
Trial arms changed: 6 -> 2
2026-05-15 NCT07566377
Cord Blood Transplantation in Children and Young Adults With Blood Cancer
Trial sites reduced: 7 -> 1 locations
New Trial Filings, Last 30 Days
First PostedTrialPhaseStatus
2026-06-09 NCT07636486 Luspatercept vs Epoetin in Treating Poor Erythroid Engraftment for Hematological… Phase 2/3 Not Yet Recruiting
Active Studies by Phase
Phase 4
2
Phase 3
8
Phase 2/3
3
Phase 2
25
Phase 1/2
2
Phase 1
1
Not specified
3
Active Trials — top 25 of 44
NCT IDTitleConditionStatus
Phase 4
NCT07381556 Cyclosporine Or Methotrexate for Pediatric Alopecia Areata: Routine Clinical Care… Alopecia Areata(AA) Recruiting
NCT07352566 Utilization of a Microdevice for Psoriasis and Atopic Dermatitis Psoriasis Not Yet Recruiting
Phase 3
NCT04877288 A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney… Renal Allograft Recipients Recruiting
NCT04064060 A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other… Myelodysplastic Syndromes (MDS) Recruiting
NCT06658002 Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A Fungal Keratitis Recruiting
NCT07345000 A Study of Romiplostim N01 Plus IST vs. Placebo Plus IST for Treatment-Naive Severe… Treatment-naïve Severe Aplastic Anemia Not Yet Recruiting
NCT04547049 A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From… Leukemia Active, Not Recruiting
NCT07548671 Enarodustat + CsA vs CsA in Newly Diagnosed TD-NSAA Transfusion-dependent Non-severe Aplastic Anemia Not Yet Recruiting
NCT05949684 ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants… Myelodysplastic Syndromes Active, Not Recruiting
NCT05600426 A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients… Severe Aplastic Anemia Active, Not Recruiting
Phase 2/3
NCT07366801 Co-infusion of Treg-enriched Donor Lymphocytes With CD3-depleted Hematopoietic Stem Cell… Acute Myeloid Leukemia, Relapsed Recruiting
NCT07539779 Luspatercept in Preventing Poor Erythroid Engraftment for Hematological Malignancies With… Luspatercept Not Yet Recruiting
NCT07636486 Luspatercept vs Epoetin in Treating Poor Erythroid Engraftment for Hematological… Luspatercept Not Yet Recruiting
Phase 2
NCT04143724 Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta… Beta-Thalassemia Recruiting
NCT06013423 Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in… Acute Leukemia of Ambiguous Lineage Recruiting
NCT04304820 Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive… Severe Aplastic Anemia Recruiting
NCT03970096 Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant… Acute Leukemia Recruiting
NCT07096297 Luspatercept + Darbepoetin in MDS MDS (Myelodysplastic Syndrome) Recruiting
NCT05664737 A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to… Anemia Recruiting
NCT06788691 Luspatercept for Clonal Cytopenias of Uncertain Significance CCUS Clonal Cytopenia of Undetermined Significance Recruiting
NCT01624805 Methylprednisolone, Horse Anti-Thymocyte Globulin, Cyclosporine, Filgrastim, and/or… Aplastic Anemia Recruiting
NCT06517875 Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion… Primary Myelofibrosis Recruiting
NCT05946772 Cyclosporine In Takotsubo Syndrome Takotsubo Cardiomyopathy Recruiting
NCT04888741 Methods of T Cell Depletion Trial (MoTD) Acute Myeloid Leukemia Recruiting
NCT07566377 Cord Blood Transplantation in Children and Young Adults With Blood Cancer Acute Myelogenous Leukemia Recruiting
Sponsors Running Luspatercept Trials
Disease Areas
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