Disease landscape

PTSD clinical trials

Get alerts when PTSD trials change

467 active trials 283 recruiting 14 Phase 3 273 sponsors 63 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 44 of 63 changes on 20 trials

2026-08-14
Trial terminated
Trial terminated: For logistical reasons at one study site.
Enrollment reduced: 60 → 41 participants
Primary completion pushed: 2024-12 → 2025-03-30
NCT06118606 Pilot Study of a Multidisciplinary Intervention in ICU Survivors at Risk for… · Region Stockholm
2026-08-20
Primary completion pushed: 2026-07-06 → 2027-03-31
Completion pushed: 2027-03-31 → 2027-09-30
NCT05776056 Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints · VA Office of Research and Development · Phase 4
2026-08-25
Primary completion pushed: 2026-07-07 → 2029-04-30
Completion pushed: 2026-07-07 → 2029-04-30
NCT01044160 Stress, Adjustment And Growth In Children With Cancer And Their Parents · St. Jude Children's Research Hospital
2026-08-13
Primary completion pushed: 2025-06-30 → 2026-12-31
Completion pushed: 2025-12-30 → 2027-12-31
NCT04519229 Child-Parent Psychotherapy - a Feasibility Study for Children in Foster Care · Kronoberg County Council
2026-08-20
Primary completion pushed: 2026-06-30 → 2027-07-31
Completion pushed: 2026-06-30 → 2027-07-31
NCT06093906 Positive Processes and Transition to Health (PATH) · Case Western Reserve University
2026-08-14
Primary completion pushed: 2026-06-01 → 2026-11-01
Enrollment closed, study ongoing
Completion pushed: 2026-06-01 → 2027-06-01
NCT06853912 PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and… · Nathan Brashares Sackett · Phase 2
2026-08-12
Primary completion pushed: 2027-06-30 → 2028-10
Completion pushed: 2027-11-30 → 2028-12-30
NCT07224698 Inhaled Cannabis for Treatment of PTSD · Multidisciplinary Association for Psychedelic Studies · Phase 2
2026-08-12
Primary completion pushed: 2025-07-01 → 2026-10-01
Completion pushed: 2025-12-01 → 2026-12-01
NCT05133804 Efficacy of Reboxetine and Methylphenidate Treatment on Attentional, Sensory and… · University of Haifa · Phase 2
2026-07-30
Primary completion pushed: 2026-03 → 2026-07-30
Sponsor changed: Suzanne "Sue" Sisley MD → Scottsdale Research Institute
Enrollment closed, study ongoing
Completion pushed: 2026-03 → 2026-10-01
NCT07275970 Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat… · Scottsdale Research Institute · Phase 1
2026-08-13
Primary completion pushed: 2026-06-30 → 2026-09-30
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Completion pushed: 2026-06-30 → 2026-10-31
NCT07132905 Mpata Yathu Trial for Young Women in Zambia · University of California, San Francisco
2026-08-04
Primary endpoint(s) modified
Trial completed
Completion moved earlier: 2026-05-01 → 2024-07-31
NCT03851380 Improving Brain Stimulation Through Imaging · VA Office of Research and Development
2026-08-28
Enrollment reduced: 100 → 90 participants
Enrollment closed, study ongoing
NCT05683132 Treatments in Women Veterans With Insomnia and PTSD · VA Office of Research and Development
2026-08-12
Enrollment reduced: 514 → 100 participants
NCT06806267 Study of the Effectiveness of VRET Combined With tDCS in the Treatment of PTSD in… · Malek Bajbouj
2026-07-31
Enrollment reduced: 136 → 66 participants
Trial completed
NCT05662423 Preventing Childbirth-Related PTSD With Expressive Writing · Massachusetts General Hospital
2026-08-27
Phase changed: Phase 1 → Phase 1/2
Sponsor changed: Wayne State University → Leslie Lundahl
NCT06222268 Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to… · Leslie Lundahl · Phase 1/2
2026-08-19
Recruitment opened
NCT07570654 Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in… · COMPASS Pathways · Phase 2/3
2026-08-27
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-08-31 → 2027-03
Completion moved earlier: 2027-08-31 → 2027-03
NCT06117306 MDMA-assisted Massed Prolonged Exposure for PTSD · Healing Breakthrough · Phase 3
2026-08-28
Recruitment opened
NCT07563296 KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury · Irma Fleming · Phase 2
2026-08-25
Enrollment closed, study ongoing
Enrollment increased: 162 → 350 participants
NCT05737693 Enhancing Week-long Psychological Treatment for PTSD With Ketamine · Yale University · Phase 2
2026-08-28
Trial status changed: Enrolling by Invitation → Completed
NCT06993012 An Integrative, Digital Health Approach to Veteran-Centered PTSD Care · Texas A&M University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-08-24 NCT07783516 Grappling With Trauma: Brazilian Jiu-Jitsu for First Responders Sam Houston State University new
2026-08-24 NCT07781904 Psychoeducation-Supported Breathing and Relaxation for Earthquake Survivors Rana Ceviz new
2026-08-20 NCT07775677 IPV Prevention Among FDP George Mason University new
2026-08-20 NCT07776769 EMDR Grief Protocol for Traumatic Grief After Earthquake-Related Loss Istanbul Bilgi University new
2026-08-19 NCT07773935 ONE-P TMS First Responders Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA new Phase 2
2026-08-14 NCT07765693 MDMA-AT for PTSD in Young Adults With Childhood Trauma Jenna M. Traynor new Phase 2
2026-08-14 NCT07766265 NEST: A Group Intervention for Parents With Complex PTSD St.Gallen University of Applied Sciences new
2026-08-11 NCT07756723 The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported… Coatesville VA Medical Center new Phase 2/3
2026-08-05 NCT07747415 PTSD Risk Prediction Model for EICU Survivors Sir Run Run Shaw Hospital new
2026-07-30 NCT07737054 Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSD Tel-Aviv Sourasky Medical Center new Early Phase 1

Active trials by phase

Early Phase 1
10
Phase 1
11
Phase 1/2
3
Phase 2
49
Phase 2/3
4
Phase 3
10
Phase 4
9
Not charted: 371 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 467

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05776056 Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints VA Office of Research and Development Recruiting 2026-08-19
NCT06573970 Atomoxetine and Executive Function in PTSD VA Office of Research and Development Recruiting 2026-07-07
NCT07382596 Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD Dr. Dean Reeves Clinic Recruiting 2026-05-19
NCT06903819 Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients Texas Tech University Health Sciences Center Recruiting 2026-03-24
NCT06414356 The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD Margaux M. Salas, PhD Recruiting 2025-02-25
NCT07686731 Suvorexant 3 - PE-PC Northern California Institute of Research and Education Not Yet Recruiting 2026-07-07
NCT04961190 A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for… University of Pennsylvania Active, Not Recruiting 2026-06-09
NCT06788522 The Effects of Orexin Antagonism on Fear Extinction in PTSD VA Office of Research and Development Not Yet Recruiting 2026-06-02
NCT07192536 Accelerated Neuromodulation for Concurrent Post-Traumatic Stress Disorder (PTSD) &… Legion Veterans Village Research Foundation Not Yet Recruiting 2025-11-18
Phase 3
NCT07703722 Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis… Khyber Medical University Peshawar Recruiting 2026-07-14
NCT07280065 REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool Senseye, Inc. Recruiting 2026-04-29
NCT04877093 Repurposing Low-Dose Clonidine for PTSD in Veterans Wake Forest University Health Sciences Recruiting 2026-03-31
NCT06394284 Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational… Herzog Hospital Recruiting 2024-05-01
NCT04985344 Treatment of Pediatric Post-traumatic Stress Disorder With Memory Reactivation Under the… University Hospital, Toulouse Recruiting 2023-08-28
NCT06117306 MDMA-assisted Massed Prolonged Exposure for PTSD Healing Breakthrough Active, Not Recruiting 2026-08-26
NCT03539614 Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests VA Office of Research and Development Active, Not Recruiting 2026-08-14
NCT07167940 Rapid Acceleration Process for Intensive Treatment of PTSD in 5 Days VA Office of Research and Development Not Yet Recruiting 2026-07-29
NCT07418554 Sleep Disturbances in Children and Adolescents With Post-traumatic Stress Disorder… University Hospital, Strasbourg, France Not Yet Recruiting 2026-02-18
NCT05427500 Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder The Royal's Institute of Mental Health Research Enrolling by Invitation 2025-07-25
Phase 2/3
NCT07570654 Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in… COMPASS Pathways Recruiting 2026-08-18
NCT07756723 The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported… Coatesville VA Medical Center Recruiting 2026-08-11
NCT06589505 Software as a Medical Device for the Treatment of Patients With PTSD Otsuka Medical Devices Co., Ltd. Japan Recruiting 2025-11-21
NCT05637879 Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder White River Junction Veterans Affairs Medical Center Recruiting 2025-04-24
Phase 2
NCT07563296 KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury Irma Fleming Recruiting 2026-08-27
NCT07771530 The Efficacy of a Pharmacological Treatment (Reboxetine Plus Ritalin) Versus Dog-Assisted… University of Haifa Recruiting 2026-08-18
See all 467 active PTSD trials with filters →

Top sponsors by active trials in this area

VA Office of Research and Development (41) · Medical University of South Carolina (11) · Karolinska Institutet (10) · Stanford University (8) · The University of Texas Health Science Center at San Antonio (8) · Emory University (6) · Massachusetts General Hospital (6) · The University of Texas Health Science Center, Houston (6) · Yale University (6) · Ohio State University (5)

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