Clinical Trial

Enhancing Week-long Psychological Treatment for PTSD With Ketamine

Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
The purpose of this study is to test if the combination of ketamine, vs midazolam, with an intensive trauma-focused psychotherapy will be more effective in relieving post-traumatic stress disorder (PTSD). This week-long treatment has the potential to produce a significant therapeutic effect that otherwise would take months to occur. The study will also focus on learning about the neurophysiological changes produced by the proposed clinical trial.
Protocol Amendment History 9 amendments
This ClinicalTrials.gov record has been amended 9 times since 2023-02-10; most recent amendment 2025-05-06.
Status change: Not Yet Recruiting → Recruiting 2023-05-18
Trial Details
NCT Number NCT05737693
Lead Sponsor Yale University
Collaborators: National Institute of Mental Health (NIMH)
Conditions Posttraumatic Stress Disorder
Enrollment 162 participants
Start Date 2023-08-21
Primary Completion 2030-08-01 (estimated)
Study Completion 2031-08-01 (estimated)
Updated on ClinicalTrials.gov 2025-05-07