Disease landscape

Head and Neck Cancer clinical trials

Get alerts when Head and Neck Cancer trials change

555 active trials 316 recruiting 28 Phase 3 309 sponsors 73 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 45 of 73 changes on 19 trials

2026-08-25
critical
Primary completion pushed: 2027-12 → 2028-12
Completion pushed: 2029-12 → 2030-12
NCT04178174 Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer · Centre hospitalier de l'Université de Montréal (CHUM) · Phase 3
2026-07-30
critical
Primary completion pushed: 2026-10-30 → 2033-07
Primary endpoint(s) modified
Enrollment reopened
Enrollment increased: 296 → 340 participants
Completion pushed: 2027-05-12 → 2033-07
Trial arms changed: 14 → 15
NCT04198766 Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in… · Inhibrx Biosciences, Inc · Phase 1/2
2026-08-28
critical
Primary completion pushed: 2026-02-28 → 2026-08-31
Enrollment reduced: 20 → 14 participants
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Completion pushed: 2026-02-28 → 2026-10-31
NCT05937269 Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer… · The University of Texas Health Science Center, Houston · Phase 1
2026-08-06
critical
Primary completion pushed: 2026-05 → 2027-06
Primary endpoint(s) modified
Completion pushed: 2026-05 → 2027-06
Trial arms changed: 17 → 18
NCT04999761 AB122 Platform Study · Taiho Pharmaceutical Co., Ltd. · Phase 1
2026-08-21
critical
Primary completion pushed: 2026-06-01 → 2026-12-01
NCT06998069 Head and Neck Cancer Study Project in the Geriatric Population · Brown University · Phase 3
2026-08-19
notable
Primary completion pushed: 2026-07-31 → 2026-12-31
Completion pushed: 2027-01-31 → 2027-03-31
NCT06239220 PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC · Dana-Farber Cancer Institute · Phase 2
2026-07-30
critical
Primary completion pushed: 2024-11-27 → 2025-07-22
Primary endpoint(s) modified
Completion pushed: 2025-12-11 → 2027-01-14
NCT04576091 Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the… · National Cancer Institute (NCI) · Phase 1
2026-08-11
critical
Primary completion pushed: 2025-05-23 → 2026-11-25
NCT02955290 CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced… · Roswell Park Cancer Institute · Phase 1/2
2026-08-14
critical
Primary completion pushed: 2025-06 → 2027-07-09
Recruitment opened
Completion pushed: 2026-09 → 2029-03-09
NCT05946577 Association Between Tinnitus and Hearing Loss in Locally Advanced Head and Neck Cancer… · Assistance Publique - Hôpitaux de Paris
2026-08-13
notable
Primary completion pushed: 2026-06-30 → 2026-09-30
Completion pushed: 2026-08-31 → 2026-09-30
NCT06531083 Feasibility of Prospective Surveillance and Early Physical Therapy for Trismus · University of Alberta
2026-08-11
critical
Primary completion pushed: 2025-09-30 → 2027-09-30
Primary endpoint(s) modified
NCT06666881 Skeletal Muscle Mass Changes on Images for Prediction of Prognosis After Exercise… · Chang Gung Memorial Hospital
2026-08-07
critical
Primary completion pushed: 2026-08-25 → 2028-08-25
Completion pushed: 2026-08-25 → 2028-08-25
NCT05995821 Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2026-08-06
critical
Primary completion pushed: 2025-12-01 → 2027-12-01
Completion pushed: 2025-12-01 → 2027-12-01
NCT06108089 Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized… · University of Utah
2026-08-05
critical
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2026-07 → 2027-07
NCT02507141 Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing… · Memorial Sloan Kettering Cancer Center
2026-08-13
critical
Enrollment reduced: 60 → 37 participants
Trial completed
Primary completion pushed: 2026-06 → 2026-07-06
Completion pushed: 2026-06 → 2026-07-06
NCT06289049 Heavy Strength Training in Head and Neck Cancer Survivors · University of Alberta · Phase 2
2026-08-09
notable
Sponsor changed: ITM Oncologics GmbH → Lumara Bio Oncologics GmbH
NCT05706129 A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452… · Lumara Bio Oncologics GmbH · Phase 1/2
2026-08-25
notable
Trial completed
NCT02446249 Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding… · MeiraGTx, LLC · Phase 1
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07457346 A Study Testing Emactinib Sulfate With Chemotherapy and Immunotherapy Before Surgery for… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 2
2026-08-09
notable
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07447570 Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for… · Second Affiliated Hospital, School of Medicine, Zhejiang University · Phase 2
2026-07-31
notable
Sponsor changed: Glenn J. Hanna → Dana-Farber Cancer Institute
NCT06239220 PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC · Dana-Farber Cancer Institute · Phase 2

Active trials by phase

Early Phase 1
10
Phase 1
60
Phase 1/2
35
Phase 2
117
Phase 2/3
6
Phase 3
22
Phase 4
6
Not charted: 299 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 555

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07189897 Apixaban or Enoxaparin After Head and Neck Cancer Surgery Kiranya Arnold Recruiting 2025-10-08
NCT06734598 Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with… National Taiwan University Hospital Recruiting 2024-12-16
NCT07697287 Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An… McMaster University Active, Not Recruiting 2026-07-13
NCT07635420 Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical… Region Skane Not Yet Recruiting 2026-06-09
NCT06879691 A Trial of Nimotuzumab and Pinkiller Efficacy and Pain in Advanced Head and Neck Squamous… Biotech Pharmaceutical Co., Ltd. Active, Not Recruiting 2025-03-17
NCT06807034 Impact of the Oral Microbiota on Relapse in HNSCC Patients Institut Sainte Catherine Active, Not Recruiting 2025-02-04
Phase 3
NCT04178174 Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer Centre hospitalier de l'Université de Montréal (CHUM) Recruiting 2026-08-24
NCT06998069 Head and Neck Cancer Study Project in the Geriatric Population Brown University Recruiting 2026-08-20
NCT07441681 Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and… NRG Oncology Recruiting 2026-08-17
NCT06589804 Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment… National Cancer Institute (NCI) Recruiting 2026-08-05
NCT07276399 A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC… Janssen Research & Development, LLC Recruiting 2026-07-31
NCT06641791 Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in… Canadian Cancer Trials Group Recruiting 2026-07-14
NCT07672236 A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in… OncoZenge AB Recruiting 2026-07-13
NCT06525220 A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in… Merus B.V. Recruiting 2026-06-02
NCT05815927 Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer European Organisation for Research and Treatment of Cancer - EORTC Recruiting 2026-05-28
NCT07264075 Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus… Groupe Oncologie Radiotherapie Tete et Cou Recruiting 2026-05-20
NCT06992427 High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral… Alliance for Clinical Trials in Oncology Recruiting 2026-05-11
NCT07467083 Development and Application of a Nurse-Led Preemptive Symptom Management Protocol for… West China Hospital Recruiting 2026-04-01
NCT06248996 a Multicentre Phase III Study of Risk-based Treatment Intensification With… Lund University Hospital Recruiting 2024-09-19
NCT05273307 Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving… University of California, San Francisco Active, Not Recruiting 2026-08-11
NCT05078047 Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3… UNICANCER Active, Not Recruiting 2026-07-17
NCT07667296 APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma Aveta Biomics, Inc. Not Yet Recruiting 2026-07-01
NCT04590963 Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus… AstraZeneca Active, Not Recruiting 2026-06-01
NCT01266044 Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia M.D. Anderson Cancer Center Active, Not Recruiting 2026-04-16
NCT06790966 Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck… PDS Biotechnology Corp. Active, Not Recruiting 2026-04-06

Top sponsors by active trials in this area

Get alerts when Head and Neck Cancer trials change
Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.
Start monitoring free