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NCT05937269 · ClinicalTrials.gov record · last posted 2026-08-27

Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship

StatusActive, Not Recruiting
PhasePhase 1
Started2023-10-12
View on ClinicalTrials.gov ↗
from the ClinicalTrials.gov record
The goal of this clinical trial is to learn if treating the lymphatics in head and neck cancer survivors before clinical diagnosis of lymphedema will prevent its development or progression. The main questions it aims to answer are: * Does early lymphatic treatment, before onset of clinical symptoms, prevent the development of head and neck lymphedema? * Does dermal lymphatic backflow provide an early indication of lymphedema and its response to treatment? Over the course of one year, participants will undergo several sessions near-infrared fluorescence lymphatic imaging to assess whether they have abnormal dermal lymphatic backflow following head and neck cancer treatment. Subjects will be divided into two groups, a treated and a control group. The treated group will be asked to complete daily sessions of pneumatic compression therapy at home, while the control group will receive standard-of-card treatment after clinical diagnosis of lymphedema. Researchers will compare the incidence of lymphedema between the two groups to see if treatment before diagnosis prevents the development and progression of head and neck lymphedema.

Protocol amendment history 4 changes detected by DataLookout

2026-08-28
notable
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
2026-08-28
critical
Enrollment reduced: 20 → 14 participants
2026-08-28
critical
Primary completion pushed: 2026-02-28 → 2026-08-31
2026-08-28
minor
Completion pushed: 2026-02-28 → 2026-10-31
Trial Details
NCT Number NCT05937269
Lead Sponsor The University of Texas Health Science Center, Houston
Conditions Lymphedema of Face, Head and Neck Cancer
Enrollment 14 participants
Start Date 2023-10-12
Primary Completion 2026-08-31 (estimated)
Study Completion 2026-10-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-27