Clinical Trial

Head and Neck Cancer Study Project in the Geriatric Population

Recruiting Phase 3
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Record status
This record was last updated December 30, 2025 (before its estimated June 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a study conducted in patients with a diagnosis of stage IB-IVA squamous cell carcinoma of the head and neck. Patients will have a comprehensive geriatric assessment (CGA) as part of standard assessments. The patients classified as frail, with a CGA score of 3-5, will then be treated with a novel reduced intensity regimen. The regimen will be tailored based on the programmed cell death ligand 1 combined positive score (PD-L1 CPS) and will involve 4 cycles of systemic chemotherapy and/or immunotherapy followed by radiation treatment.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-05-28; most recent amendment 2025-12-28.
Status change: Not Yet Recruiting → Recruiting 2025-12-28
Trial Details
NCT Number NCT06998069
Lead Sponsor Brown University
Collaborators: The Miriam Hospital, Rhode Island Hospital
Conditions Head and Neck Neoplasms
Enrollment 20 participants
Start Date 2025-08-27
Primary Completion 2026-06-01 (estimated)
Study Completion 2027-06-01 (estimated)
Updated on ClinicalTrials.gov 2025-12-30