NCT05273307 · ClinicalTrials.gov record · last posted 2026-08-11
Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving Radiation Therapy
StatusActive, Not Recruiting
PhasePhase 3
Started2022-03-04
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from the ClinicalTrials.gov record
Patients diagnosed with head and neck cancer who receive radiation therapy with and without chemotherapy develop altered sense of taste due to treatment effect, which typically arises in the second week of radiation therapy and progresses throughout the course of treatment. While some symptoms such as pain, mucositis, and xerostomia can be managed with pain medications and saliva replacements, taste alteration has an earlier onset and is a more difficult symptom to readily address and intervene upon. There are no effective established interventions for taste, although this is a major issue in the patient experience. The investigator will be examining they hypothesis that a miracle fruit cube would yield the greatest benefit to improve taste dysfunction in the beginning half of radiation treatment when taste function is decreased but not absent.
Amendment record
8 amendments on the ClinicalTrials.gov record
This ClinicalTrials.gov record has been amended 8 times since 2022-03-01; most recent amendment 2026-06-15. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history.
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2026-06-15
Status change Recruiting→Active, Not Recruitingv8
2022-06-27
Status change Not Yet Recruiting→Recruitingv4
| NCT Number |
NCT05273307 |
| Lead Sponsor |
University of California, San Francisco
Collaborators: Miracle Fruit Farm, Mount Zion Health Fund |
| Conditions |
Head and Neck Cancer, Taste Dysfunction |
| Enrollment |
40 participants |
| Start Date |
2022-03-04 |
| Primary Completion |
2026-11-30 (estimated) |
| Study Completion |
2026-11-30 (estimated) |
| Updated on ClinicalTrials.gov |
2026-08-11 |