| Detected | Trial | Change |
|---|---|---|
| 2026-06-09 | NCT06185764 A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1) |
Enrollment increased: 44 -> 52 participants |
| 2026-06-09 | NCT06185764 A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1) |
date change Primary completion pushed: 2026-12-22 -> 2027-02-02 |
| 2026-06-09 | NCT06185764 A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1) |
date change Completion pushed: 2026-12-22 -> 2027-02-02 |
| 2026-06-09 | NCT07584434 A Phase 1, First-in-human Study of VX-433 |
Recruitment opened |
| 2026-06-06 | NCT07204275 Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With… |
Trial sites expanded: 93 -> 98 locations |
| 2026-06-05 | NCT05791201 A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes |
Primary endpoint(s) modified |
| 2026-06-05 | NCT05791201 A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes |
date change Primary completion pushed: 2026-05-29 -> 2027-03-12 |
| 2026-06-05 | NCT05791201 A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes |
date change Completion pushed: 2026-05-29 -> 2027-03-12 |
| 2026-06-03 | NCT07570069 Effects of Efavirenz on the Pharmacokinetics of Suzetrigine in Healthy Participants |
Recruitment opened |
| 2026-06-02 | NCT06619860 Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral… |
date change Primary completion pushed: 2026-04-30 -> 2027-03-25 |
| 2026-06-02 | NCT06619860 Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral… |
date change Completion pushed: 2026-05-30 -> 2027-04-22 |
| 2026-05-29 | NCT05422222 Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1… |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-05-27 | NCT06154447 Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-05-27 | NCT06154447 Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis |
Enrollment reduced: 255 -> 165 participants |
| 2026-05-27 | NCT06154447 Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis |
date change Primary completion pushed: 2026-04-23 -> 2026-07-16 |
| 2026-05-27 | NCT06154447 Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis |
date change Completion pushed: 2026-04-23 -> 2026-07-16 |
| 2026-05-23 | NCT05668741 A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF) |
overall status: "Recruiting" → "Active Not Recruiting" |
| 2026-05-23 | NCT05668741 A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF) |
Enrollment reduced: 39 -> 26 participants |
| 2026-05-23 | NCT05668741 A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF) |
Trial sites reduced: 43 -> 26 locations |
| 2026-05-23 | NCT05668741 A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF) |
date change Primary completion moved earlier: 2026-12-23 -> 2026-04-21 |
| NCT ID | Title | Condition | Status |
|---|---|---|---|
| Phase 4 | |||
| NCT07538570 | Evaluation of Pain Treatment After Total Knee Arthroplasty | Pain | Recruiting |
| Phase 3 | |||
| NCT04786262 | A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes | Diabetes Mellitus, Type 1 | Recruiting |
| NCT05477563 | Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With… | Beta-Thalassemia | Recruiting |
| NCT06832410 | An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1… | Type 1 Diabetes | Recruiting |
| NCT06628908 | Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic… | Diabetic Peripheral Neuropathic Pain | Recruiting |
| NCT07231419 | Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic… | Diabetic Peripheral Neuropathic Pain | Recruiting |
| NCT05356195 | Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With… | Beta-Thalassemia | Active, Not Recruiting |
| NCT05329649 | Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle… | Sickle Cell Disease | Active, Not Recruiting |
| NCT04208529 | A Long-term Follow-up Study in Participants Who Received CTX001 | Beta-Thalassemia | Enrolling by Invitation |
| NCT05844449 | Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in… | Cystic Fibrosis | Enrolling by Invitation |
| NCT05444257 | A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy | Cystic Fibrosis | Active, Not Recruiting |
| NCT06564142 | Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN) | Immunoglobulin A Nephropathy | Active, Not Recruiting |
| NCT06696443 | Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants… | Diabetic Peripheral Neuropathic Pain | Active, Not Recruiting |
| NCT05422222 | Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1… | Cystic Fibrosis | Active, Not Recruiting |
| NCT05331183 | Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and… | Cystic Fibrosis | Active, Not Recruiting |
| NCT06460506 | Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis… | Cystic Fibrosis | Active, Not Recruiting |
| Phase 2/3 | |||
| NCT05312879 | Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With… | Proteinuric Kidney Disease | Recruiting |
| NCT07204275 | Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With… | Primary Membranous Nephropathy | Recruiting |
| Phase 2 | |||
| NCT07161037 | Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene… | Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Recruiting |
| NCT07501702 | A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis | Myasthenia Gravis, Generalized | Recruiting |
| NCT06619860 | Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral… | Diabetic Peripheral Neuropathic Pain | Recruiting |
| NCT06794996 | Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease With or Without… | Proteinuric Kidney Disease | Active, Not Recruiting |
| NCT06926621 | A Study of Long-term Safety and Efficacy of VX-670 in Participants With Myotonic… | Myotonic Dystrophy Type 1 (DM1) | Enrolling by Invitation |
| Phase 1/2 | |||
| NCT06185764 | A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1) | Myotonic Dystrophy Type 1 (DM1) | Recruiting |
| NCT05668741 | A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF) | Cystic Fibrosis | Active, Not Recruiting |