Disease landscape

Cystic Fibrosis clinical trials

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224 active trials 139 recruiting 13 Phase 3 144 sponsors 25 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days

2026-07-30
Recruitment suspended
Recruitment suspended: The pause is for strategic business reasons to facilitate internal portfolio review. The pause is not due to any...
Completion pushed: 2028-08-07 → 2029-05-11
NCT07547436 A Study to Access Activity and Safety With SAR445399 Compared With Placebo in… · Sanofi · Phase 2
2026-08-01
Primary completion pushed: 2026-03-01 → 2027-09-01
Completion pushed: 2026-09-30 → 2027-09-30
NCT06560463 Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in… · Medical College of Wisconsin
2026-08-20
Enrollment reduced: 192 → 128 participants
Enrollment closed, study ongoing
Primary completion pushed: 2026-08-30 → 2026-11
Completion moved earlier: 2026-12-31 → 2026-11
NCT06237335 A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy… · ReCode Therapeutics · Phase 2
2026-08-04
Primary endpoint(s) modified
NCT07692594 Heart and Blood Vessels Health in People With Cystic Fibrosis · Liverpool Heart and Chest Hospital NHS Foundation Trust
2026-08-26
Phase changed: Early Phase 1 → not specified
Primary completion pushed: 2026-07-31 → 2026-09-01
Completion moved earlier: 2026-12-30 → 2026-11-01
NCT06163482 Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis · University of Cincinnati
2026-08-18
Trial completed
NCT07289464 A Clinical Study of RSS0343 in Healthy Subjects · Reistone Biopharma Company Limited · Phase 1
2026-08-12
Recruitment opened
Trial sites expanded: 0 → 3 locations
NCT07720375 A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in… · UCB Biopharma SRL · Phase 2
2026-08-11
Trial completed
NCT06154447 Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis · Vertex Pharmaceuticals Incorporated · Phase 1
2026-08-22
Enrollment closed, study ongoing
NCT06810167 Assessing Tenapanor as a Treatment of CF-related Constipation. · Massachusetts General Hospital · Phase 3
2026-08-04
Trial status changed: Recruiting → Enrolling by Invitation
NCT07102043 Glucose Metabolism in Cystic Fibrosis Related Diabetes (CFRD) · University of Alabama at Birmingham
2026-07-30
Trial completed
Primary completion moved earlier: 2026-06-01 → 2026-02-01
Completion moved earlier: 2026-06-01 → 2026-02-01
NCT04687475 Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic… · The Cleveland Clinic
2026-08-15
Primary completion pushed: 2028-06-30 → 2028-08-30
Completion pushed: 2028-06-30 → 2028-08-30
NCT07692594 Heart and Blood Vessels Health in People With Cystic Fibrosis · Liverpool Heart and Chest Hospital NHS Foundation Trust
2026-08-09
Trial status changed: Not Yet Recruiting → Unknown
NCT06352944 Procalcitonin as a Marker of Severity of Non-cystic Fibrosis Bronchiectasis in Children · Assiut University

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-07-23 NCT07722364 HFCWO in Children With Non-CF Bronchiectasis Sphinx university new
2026-07-22 NCT07720375 A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in… UCB Biopharma SRL new Phase 2
2026-07-16 NCT07709494 A Phase 1a/1b Study to Investigate the Safety, Tolerability, Microbiological Response… Revagenix, Inc. new Phase 1
2026-07-09 NCT07692594 Heart and Blood Vessels Health in People With Cystic Fibrosis Liverpool Heart and Chest Hospital NHS Foundation Trust new
2026-07-07 NCT07688070 Verapamil Effect in Cystic Fibrosis-related Dysglycemia Rhode Island Hospital new Phase 2
2026-06-24 NCT07665203 Home Air Pollution in Children With Cystic Fibrosis Study Seattle Children's Hospital new
2026-06-17 NCT07653633 Prospective Cohort Study of Villarreal CF Youth Players Cardenal Herrera University new
2026-06-08 NCT07632768 Safety of Stopping Pancreatic Enzyme Replacement Therapy in Children With Improved… Indiana University new Phase 4
2026-06-05 NCT07629986 Pharmacokinetics of Antibiotics in Patients With Cystic Fibrosis Trated With… Fondation Ildys new
2026-06-01 NCT07616375 A Study to Assess the Safety of HSK31858 in Participants With Non-Cystic Fibrosis… Haisco Pharmaceutical Group Co., Ltd. new Phase 3

Active trials by phase

Early Phase 1
5
Phase 1
12
Phase 1/2
4
Phase 2
19
Phase 2/3
2
Phase 3
11
Phase 4
10
Not charted: 161 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 224

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05548283 Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study Chris Goss Recruiting 2026-07-08
NCT07148739 Ensuring Access to Optimal Therapy in CF: The ENACT Study Arkansas Children's Hospital Research Institute Recruiting 2026-06-02
NCT03921060 Markers of Osteoporosis in Cystic Fibrosis University of Texas Southwestern Medical Center Recruiting 2026-05-05
NCT05704036 Estrogen Supplementation and Bone Health in Women With CF Johns Hopkins University Recruiting 2025-11-14
NCT06242795 Hypertonic Saline in NCFB University of North Carolina, Chapel Hill Recruiting 2025-08-13
NCT05517655 BEGIN Novel ImagiNG Biomarkers Children's Hospital Medical Center, Cincinnati Recruiting 2024-11-21
NCT07608328 Azithromycin to Modify Bronchiectasis Exacerbation Risk Assiut University Not Yet Recruiting 2026-05-27
NCT04467957 Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic Fibrosis Children's Hospital Medical Center, Cincinnati Active, Not Recruiting 2026-01-28
NCT04259970 Hyperpolarized Imaging for New Treatments Children's Hospital Medical Center, Cincinnati Active, Not Recruiting 2026-01-07
NCT04602468 Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF… Royal College of Surgeons, Ireland Active, Not Recruiting 2024-05-02
Phase 3
NCT06449677 Bionic Pancreas in CFRD Jaeb Center for Health Research Recruiting 2026-06-24
NCT07616375 A Study to Assess the Safety of HSK31858 in Participants With Non-Cystic Fibrosis… Haisco Pharmaceutical Group Co., Ltd. Recruiting 2026-06-01
NCT06996951 Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the… Indiana University Recruiting 2025-12-16
NCT06660992 A Study to Assess the Efficacy and Safety of HSK31858 in Participants With Non-Cystic… Haisco Pharmaceutical Group Co., Ltd. Recruiting 2024-10-28
NCT06810167 Assessing Tenapanor as a Treatment of CF-related Constipation. Massachusetts General Hospital Active, Not Recruiting 2026-08-21
NCT05331183 Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and… Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-08-11
NCT05444257 A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-07-21
NCT06460506 Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis… Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-06-05
NCT05422222 Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1… Vertex Pharmaceuticals Incorporated Active, Not Recruiting 2026-05-28
NCT05844449 Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in… Vertex Pharmaceuticals Incorporated Enrolling by Invitation 2026-04-29
NCT07274020 Long-Term Safety and Efficacy of Moxifloxacin in Bronchiectasis Patients Assiut University Not Yet Recruiting 2025-12-10
Phase 2/3
NCT06413368 Maralixibat in Patients With Cystic Fibrosis and Constipation Children's Hospital Los Angeles Recruiting 2026-04-21
NCT06149793 SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes University of Minnesota Active, Not Recruiting 2026-01-20
Phase 2
NCT07450547 Phase 2 Study to Assess the Safety and Efficacy of ANG003 Anagram Therapeutics, Inc. Recruiting 2026-08-27
NCT07720375 A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in… UCB Biopharma SRL Recruiting 2026-08-11
See all 224 active Cystic Fibrosis trials with filters →

Top sponsors by active trials in this area

Children's Hospital Medical Center, Cincinnati (8) · Vertex Pharmaceuticals Incorporated (8) · University of North Carolina, Chapel Hill (6) · Hospices Civils de Lyon (5) · Assiut University (4) · Indiana University (4) · Johns Hopkins University (4) · Riphah International University (4) · The Hospital for Sick Children (4) · University of British Columbia (4)

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